Hypoxia-inducible factor-1α polymorphisms link to coronary artery collateral development and clinical presentation of coronary artery disease

Liu, Qian; Liang, Yun; Zou, Ping; Ni, Wei-xin; Li, Yuguang; Chen, Songming

doi:10.5507/bp.2013.061

Cited by 9 publications

(7 citation statements)

References 25 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, as HIF‐1α served as a stimulus for evolution of coronary artery collateral vessels, it was well explainable that the frequency of rs2057482 among groups of patients with single‐, double‐, and triple‐vessel lesions displayed significant difference, irrespective of patients’ menopausal condition. Consistent with previous results, rs10873142 that was located 143 bp distant from 5′ end, was also closely linked with cardiac disorders, whereas rs11549465 and rs11549467 showed scarcely any sign in their remarkable correlation with CAD risk …”

Section: Discussionsupporting

confidence: 91%

“…For the investigation on HO‐1 , the rs2071746(A > T) was found to be associated with altered susceptibility to CAD group in the allelic model (OR: 0.67, 95% CI: 0.58‐0.78, P < 0.05). According to (GT)n repeats, another HO‐1 variant was divided as class S less repeats (≤25), M, and class L more repeats (≥32). In our study, as the M allele was not found, the participants were grouped into SS, SL, and LL genotypes.…”

Section: Resultsmentioning

confidence: 99%

“…Consistent with previous results, rs10873142 that was located 143 bp distant from 5 0 end, was also closely linked with cardiac disorders, 11 whereas rs11549465 and rs11549467 showed scarcely any sign in their remarkable correlation with CAD risk. 10,25 Because HO-1 functioned as a catalyzer in converting heme to elements featured by antagonism of proliferation, oxidation, and inflammation (eg, ferrous iron, carbon monoxide, and biliverdin), 26 induction of HO-1 has been deemed as a tenable therapy for cardiovascular disorders. 27 A mouse model also suggested that elevated HO-1 expressions could, to a great extent, decrease the prevalence of atherosclerotic lesions.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Correlation between genetic polymorphisms within the MAPK1/HIF‐1/HO‐1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease

Guo

Zhang

Yan

et al. 2017

Clinical Cardiology

View full text Add to dashboard Cite

Background Mitogen‐activated protein kinase‐1 (MAPK1), as well as its downstream factors of hypoxia‐inducible factor‐1 (HIF‐1) and heme oxygenase‐1 (HO‐1), have been documented to be involved in modulating development of coronary artery disease (CAD). Hypothesis Genetic mutations within the MAPK1/HIF‐1/HO‐1 signaling pathway could alter the risk of perimenopausal CAD in Chinese patients. Methods Peripheral blood samples were gathered from 589 CAD patients and 860 healthy controls, and 12 potential single‐nucleotide polymorphisms (SNPs) were obtained from HapMap database and previously published studies. Genotyping of SNPs was implemented with the TaqMan SNP Genotyping Assays. Odds ratios (OR) and 95% confidence intervals (CI) were utilized to evaluate the correlations between SNPs and CAD risk. Results Regarding MAPK1 , rs6928 (OR: 1.71, 95% CI: 1.47‐1.98, P < 0.05), rs9340 (OR: 0.85, 95% CI: 0.73‐0.99, P < 0.05), and rs11913721 (OR: 0.70, 95% CI: 0.52‐0.95, P < 0.05) were remarkably associated with susceptibility to perimenopausal CAD. Of these, rs9340 and rs11913721 were also regarded as protective factors for perimenopausal CAD patients. Moreover, results of HIF‐1 indicated noticeable correlations between combined SNPs of rs1087314 and rs2057482 and risk of perimenopausal CAD (OR: 1.24, 95% CI: 1.01‐1.53, P < 0.05; and OR: 0.71, 95% CI: 0.55‐0.91, P < 0.05, respectively). Nonetheless, rs2071746 in HO‐1 was found to be only associated with perimenopausal CAD risk (OR: 0.67, 95% CI: 0.58‐0.78, P < 0.05). Conclusions The genetic mutations within MAPK1 (rs6928, rs9340, rs11913721), HIF‐1 (rs1087314, rs2057482), and HO‐1 (rs2071746) could alter susceptibility to perimenopausal CAD in this Chinese population.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Correlation between genetic polymorphisms within the MAPK1/HIF‐1/HO‐1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease

Guo

Zhang

Yan

et al. 2017

Clinical Cardiology

View full text Add to dashboard Cite

show abstract

“…In addition, other studies have investigated the correlation between HIF1A polymorphism and CAD. A recent study showed that HIF-1α polymorphisms (rs11549465 and rs11549467) were associated with clinical type and formation of coronary collaterals [47]. The rs2057482 SNP of HIF1A was showed to be associated with increased susceptibility to premature CAD, which may be applied in clinical diagnostics as a susceptibility marker of premature CAD [48].…”

Section: Discussionmentioning

confidence: 99%

A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting conditions

Gong¹,

Chen²,

Zhang

et al. 2017

Diagn Pathol

View full text Add to dashboard Cite

BackgroundTo support a hypothesis that there is an intrinsic interplay between coronary artery disease (CAD) and type 2 diabetes (T2D), we used RNA-seq to identify unique gene expression signatures of CAD, T2D, and coexisting conditions.MethodsAfter transcriptome sequencing, differential expression analysis was performed between each disordered state and normal control group. By comparing gene expression profiles of CAD, T2D, and coexisting conditions, common and specific patterns of each disordered state were displayed. To verify the specific gene expression patterns of CAD or T2D, the gene expression data of GSE23561 was extracted.ResultsA strong overlap of 191 genes across CAD, T2D and coexisting conditions, were mainly involved in a viral infectious cycle, anti-apoptosis, endocrine pancreas development, innate immune response, and blood coagulation. In T2D-specific PPI networks involving 64 genes, TCF7L2 (Degree = 169) was identified as a key gene in T2D development, while in CAD-specific PPI networks involving 64 genes, HIF1A (Degree = 124), SMAD1 (Degree = 112) and SKIL (Degree = 94) were identified as key genes in the CAD development. Interestingly, with the provided expression data from GSE23561, the three genes were all up-regulated in CAD, and SMAD1 and SKIL were specifically differentially expressed in CAD, while HIF1A was differentially expressed in both CAD and T2D, but with opposite trends.ConclusionsThis study provides some evidences in transcript level to uncover the association of T2D, CAD and coexisting conditions, and may provide novel drug targets and biomarkers for these diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/s13000-017-0630-7) contains supplementary material, which is available to authorized users.

show abstract

“…Analysis of genetic polymorphisms in the human HIF1A locus has shown that CAD patients with a single-nucleotide polymorphism (P582S) showed increased collateral vessel formation ( 138 ). Moreover, an initial clinical assessment of patients with CAD showed stable angina as more prevalent in subjects with multiple single nucleotide polymorphisms in the HIF1A locus compared to patients that suffered an MI ( 139 , 140 ). The stable angina group was also associated with increased coronary collaterals ( 140 , 141 ).…”

Section: Acute Pathologic Hypoxic Statesmentioning

confidence: 99%

Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

Rojas

Villanueva

Bond

2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Cardiovascular (CV) diseases are the major cause of death in industrialized countries. The main function of the CV system is to deliver nutrients and oxygen to all tissues. During most CV pathologies, oxygen and nutrient delivery is decreased or completely halted. Several mechanisms, including increased oxygen transport and delivery, as well as increased blood flow are triggered to compensate for the hypoxic state. If the compensatory mechanisms fail to sufficiently correct the hypoxia, irreversible damage can occur. Thus, hypoxia plays a central role in the pathogenesis and pathophysiology of CV diseases. Hypoxia inducible factors (HIFs) orchestrate the gene transcription for hundreds of proteins involved in erythropoiesis, glucose transport, angiogenesis, glycolytic metabolism, reactive oxygen species (ROS) handling, cell proliferation and survival, among others. The overall regulation of the expression of HIF-dependent genes depends on the severity, duration, and location of hypoxia. In the present review, common CV diseases were selected to illustrate that HIFs, and proteins derived directly or indirectly from their stabilization and activation, are related to the development and perpetuation of hypoxia in these pathologies. We further classify CV diseases into acute and chronic hypoxic states to better understand the temporal relevance of HIFs in the pathogenesis, disease progression and clinical outcomes of these diseases. We conclude that HIFs and their derived factors are fundamental in the genesis and progression of CV diseases. Understanding these mechanisms will lead to more effective treatment strategies leading to reduced morbidity and mortality.

show abstract

Hypoxia-inducible factor-1α polymorphisms link to coronary artery collateral development and clinical presentation of coronary artery disease

Cited by 9 publications

References 25 publications

Correlation between genetic polymorphisms within the MAPK1/HIF‐1/HO‐1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease

Correlation between genetic polymorphisms within the MAPK1/HIF‐1/HO‐1 signaling pathway and risk or prognosis of perimenopausal coronary artery disease

A comparison of gene expression profiles in patients with coronary artery disease, type 2 diabetes, and their coexisting conditions

Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

Contact Info

Product

Resources

About