Hypoxia-inducible factor-1: Regulatory mechanisms and drug therapy in myocardial infarction

Pan, Jinyuan; Zhang, Lei; Li, Dongxiao; Li, Yuan; Lu, Mengkai; Hu, Yuanlong; Sun, Bowen; Zhang, Zhiyuan; Li, Chao

doi:10.1016/j.ejphar.2023.176277

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2024

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“…We performed molecular docking of 10 peptides, which were predicted through online screening, to targets associated with myocardial infarction and reperfusion injury (MI/RI). These targets include tumor necrosis factor-alpha (TNF-α), 38 interleukin-6 (IL-6), 39 kelch-like ECH-associated protein 1 (Keap1), 40 caspase-3 (CASP3), 41 xanthine dehydrogenase (XDH), 42 nitric oxide synthase (NOS), 43 hypoxia-inducible factor-1 alpha (HIF-1α), 44 NADPH oxidase 2 (NOX2), 45 apoptotic protease activating factor-1 (Apaf-1), 46 and others. Fig.…”

Section: Resultsmentioning

confidence: 99%