Hypoxia-Inducible Factor-1 Alpha C1772T Gene Polymorphism and Glioma Risk: A Hospital-Based Case–Control Study from China

Xu, Guohai; Wang, Maode; Xie, Wei; Bai, Xia

doi:10.1089/gtmb.2010.0265

Cited by 16 publications

(8 citation statements)

References 28 publications

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“…An association of CT genotype of g.C1772T polymorphism has been reported with large tumor size in esophageal squamous cell carcinoma (Ling et al, 2005) and with more severe ulcerative growth pattern in colorectal adenocarcinoma (Fransen et al, 2006). In contrast to our findings, higher frequency of CT genotype has been reported in patients with breast (Naidu et al, 2009), prostate (Chau et al, 2005;Foley et al, 2009), pancreatic cancer and glioma (Xu et al, 2011). For g.C1772T polymorphism, we did not observe any significant differences in genotype and allele distribution between breast cancer patients and controls.…”

Section: Discussioncontrasting

confidence: 99%

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

Sharma¹,

Kapahi²,

Sambyal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Section: Discussioncontrasting

confidence: 99%

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

Sharma¹,

Kapahi²,

Sambyal³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Another case-control study showed that XRCC1 Arg399Gln polymorphism is a significant risk factor and that the 399Gln (G) allele carries a 3.5 times greater risk for glioma, whereas the PARP1 Val/Ala genotype may be protective against it (Yosunkaya et al, 2010). A hospital-based case-control study suggested that CT genotype and the T allele of hypoxiainducible factor-1a C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China (Xu et al, 2011). From a total of 11 SNPs in 7 cytokine genes within a hospital-based study, Brenner et al (2007) found that the IL4 (rs2243248, -1098T > G) and IL6 (rs1800795, -174G > C) polymorphisms were significantly associated with risk for glioma in the pooled analysis.…”

Section: Discussionmentioning

confidence: 99%

A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated with Risk for Glioma in a Chinese Population

Yang

Zhao

Liu

et al. 2012

Genetic Testing and Molecular Biomarkers

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Epidermal growth factor (EGF) plays a key role in survival of neural and glial precursor cells. A single nucleotide polymorphism of the EGF gene +61G/A in the 5'-untranslated region has been reported to be associated with susceptibility to glioma. The purpose of this study was to investigate the potential association between EGF +61G/A and brain glioma in a Chinese population. A case-control study involving 180 patients with glioma and 360 controls was done. Polymerase chain reaction restriction fragment-length polymorphism assay was used to analyze the EGF +61G/A genotypes. Patients with glioma had a significantly higher frequency of AA genotype (odds ratio, 2.25; 95% confidence interval, 1.20, 4.21; p=0.01] than controls. When stratified by histologic features and World Health Organization grade of glioma, distribution of each genotype did not significantly differ. Our data suggested that the EGF +61G AA genotype was associated with a higher glioma risk in a Chinese population. This finding is in contrast with previous studies that reported the G allele as a risk factor for glioma in white patients.

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“…Among 16 HIF1A SNPs associated with 40 different phenotypes six SNPs have been associated with increased risk for 14 cancer types: rs113182457, rs11549465, rs11549467, rs199775054, rs2057482, and rs2301113 . These six SNPs were most frequently associated with breast, lung, colorectal (CRC), gastric, prostate, oral cancer, and renal cell carcinoma (RCC).…”

Section: Hif1a and Cancer Riskmentioning

confidence: 99%

“…Among 16 HIF1A SNPs associated with 40 different phenotypes six SNPs have been associated with increased risk for 14 cancer types: rs113182457, 45 rs11549465, [20][21][22]24,[34][35][36][37][38][39][40][41][42][43][44][45][46][47][49][50][51][52][53][54][55][56][57][58]68,112 rs11549467, 35,36,41,43,44,50,[55][56][57][58]70,75,76,78,81,88,104,105 rs199775054, 108 rs2057482, 32,79,110,…”

Section: H I F 1 a A N D Ca N C E R R I S Kmentioning

confidence: 99%

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies

Gladek

Ferdin

Horvat

et al. 2017

Genes Chromosomes & Cancer

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Hypoxia-inducible factors (HIFs) belong to a family of transcription factors (TF) responsive to a low O2 availability, which is often a characteristic feature of solid tumors. The alpha subunit of the HIF heterodimer is O2-sensitive, and once stabilized in hypoxia, it functions as a master regulator of various genes involved in hypoxia pathway. Changes in the HIF1A (hypoxia inducible factor 1, alpha subunit) nucleotide sequence or expression has been shown to be associated with development of several diseases. Due to increasing research interest in HIF1A gene a review of association studies was needed. We here reviewed published data on single nucleotide polymorphisms (SNPs) in HIF1A in various diseases; in total, 34 SNPs were tested for an association with 49 phenotypes, and the results were visualized using the Cytoscape software. Among all collected polymorphisms 16 SNPs showed significant associations with 40 different phenotypes, including six SNPs associated with 14 cancer types. Missense SNPs (rs11549465 and rs11549467) within the oxygen-dependent degradation domain were most frequently studied. The study provides a comprehensive tool for researchers working in this area and may contribute to more accurate disease diagnosis and identification of therapeutic targets.

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Hypoxia-Inducible Factor-1 Alpha C1772T Gene Polymorphism and Glioma Risk: A Hospital-Based Case–Control Study from China

Abstract: This study suggested that CT genotype and the T allele of HIF-1α C1772T gene polymorphism were associated with a higher glioma risk in the Han population of China.

Cited by 16 publications

References 28 publications

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians

A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated with Risk for Glioma in a Chinese Population

HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies

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