Hypoxia induces radioresistance, epithelial‑mesenchymal transition, cancer stem cell‑like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma

Wiecheć, Emilia; Matic, Natasa; Ali, Ashfaq; Roberg, Karin

doi:10.3892/or.2022.8269

Cited by 14 publications

(12 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Different from previous reports, none of the subjects in this study received regular red blood cell transfusions for anemia. Tumor hypoxia has been intensively reported to be associated with decreased sensitivity to radiotherapy, previously ( Wiechec et al, 2022 ; Yan et al, 2022 ; Eisenbrey et al, 2018 ). Anemia is thought to worsen intramural hypoxia, whose presence before or during radiation treatment adversely influences tumor radiosensitivity and is independently correlated with poor locoregional disease control and overall survival ( Harrison and Blackwell, 2004 ; Tanaka et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

Ding

Huang²,

Jiang³

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

Background: Thalassemia is a common inherited hematological disease with genetic disorders characterized by imbalanced synthesis of the globin chains. Due to the improvement of treatment methods, patients with thalassemia can survive for a long time. Therefore, it is not uncommon for patients with thalassemia suffering from malignant tumors. However, there are quite few reports on thalassemia patients complicated with breast cancer. Herein, we try to investigate the prevalence and genetic disorders spectrum of thalassemia in patients with breast cancer.Methods: Blood routing tests and serum ferritin analysis were conducted in 1887 breast cancer patients treated in the department of radiation oncology during 1 April 2020 and 30 March 2022. The suspected thalassemia carriers with small mean corpuscular volume (MCV), mean corpuscular hemoglobin content (MCH) or mean corpuscular hemoglobin concentration (MCHC) but the concentration of serum ferritin within normal limits were further investigated by polymerase chain reaction (PCR) and flow through hybridization gene chip to detect common mutations of α-globin and β-globin genes using Thalassemia Geno Array Diagnostic Kit. The prevalence and genetic mutation spectrum of thalassemia among breast cancer patients were analyzed.Results: Four hundred and eighty-nine suspected thalassemia carriers were detected by complete blood cell counts and serum ferritin analysis among 1887 breast cancer patients. One hundred and seven cases (5.7%) were identified as carriers of thalassemia, of which 55 cases (51.4%) were α-thalassemia, 50 cases (46.7%) were β-thalassemia, and 2 cases (1.9%) were co-inheritance of α-thalassemia and β-thalassemia simultaneously. In α-thalassemia, the most prevalent genotype is -SEA/αα; as for β-thalassemia, βIVS−II−654/β is the most common genotype. The degree of anemia is more severe in β-thalassemia than in α-thalassemia.Conclusion: This is the first comprehensive molecular epidemiological investigation on thalassemia among breast cancer patients. Our data indicated that thalassemia was not uncommon in breast cancer patients. The physicians should have the knowledge to avoid misdiagnosis as iron deficiency anemia.

show abstract

Section: Discussionmentioning

confidence: 99%

The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

Ding

Huang²,

Jiang³

et al. 2022

Front. Genet.

View full text Add to dashboard Cite

show abstract

“…Like other solid tumours, hypoxia ensues in HNSCC when the blood supply becomes insufficient due to tumour growth, vascular disturbances or metabolic stress. Besides its pro-stemness effect, hypoxia was shown to promote anti-apoptotic pathways and tumour aggressiveness, predict poor therapeutic response and induce the formation of functional invadopodia in HNSCC cells (Refs [54][55][56][57][58]. A recent study found that hypoxia-related genes were enriched in CD44 +ve CSCs from patients with HNSCC.…”

Section: Role Of Hypoxic Microenvironmentmentioning

confidence: 99%

“…Although reports assessing the direct influence of hypoxia on CSCs in HNSCC are limited, hypoxia may mediate its pro-stemness effects through EMT. In this regard, hypoxia induced the expression of key EMT transcriptional factors and promoted pulmonary metastasis in OSCC (Refs 58, 59). Further, co-expression of hypoxia and EMT markers (Twist 2/Snip1 and HIF-1 α , respectively) served as an independent prognosticator for both OS and disease-free survival in patients with tongue SCC (TSCC) (Ref.…”

Section: Role Of Hypoxic Microenvironmentmentioning

confidence: 99%

Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma

Salem

Salo

2023

Expert Rev. Mol. Med.

View full text Add to dashboard Cite

Head and neck squamous cell carcinoma (HNSCC) represents frequent yet aggressive tumours that encompass complex ecosystems of stromal and neoplastic components including a dynamic population of cancer stem cells (CSCs). Recently, research in the field of CSCs has gained increased momentum owing in part to their role in tumourigenicity, metastasis, therapy resistance and relapse. We provide herein a comprehensive assessment of the latest progress in comprehending CSC plasticity, including newly discovered influencing factors and their possible application in HNSCC. We further discuss the dynamic interplay of CSCs within tumour microenvironment considering our evolving appreciation of the contribution of oral microbiota and the pressing need for relevant models depicting their features. In sum, CSCs and tumour plasticity represent an exciting and expanding battleground with great implications for cancer therapy that are only beginning to be appreciated in head and neck oncology.

show abstract

“…In HNSCC, hypoxia-inducible factor-1a (HIF-1α), a transcriptional regulator of oxygen homeostasis, is enhanced in CSCs subpopulations in response to radiation [ 66 ] . Furthermore, hypoxia upregulates CSCs genes such as Sox2 and Nanog , consequently contributing to the survival of tumor cells after radiation [ 67 ] . Linge et al showed a correlation between high tumor recurrence after postoperative radiochemotherapy in locally advanced HNSCC patients, increased expression of CSCs markers, and high hypoxia-induced gene signature expression [ 68 ] .…”

Section: Radioresistance and Cscmentioning

confidence: 99%

Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

Siqueira¹,

Heguedusch²,

Rodini³

et al. 2023

Cancer Drug Resist

View full text Add to dashboard Cite

Despite scientific advances in the Oncology field, cancer remains a leading cause of death worldwide. Molecular and cellular heterogeneity of head and neck squamous cell carcinoma (HNSCC) is a significant contributor to the unpredictability of the clinical response and failure in cancer treatment. Cancer stem cells (CSCs) are recognized as a subpopulation of tumor cells that can drive and maintain tumorigenesis and metastasis, leading to poor prognosis in different types of cancer. CSCs exhibit a high level of plasticity, quickly adapting to the tumor microenvironment changes, and are intrinsically resistant to current chemo and radiotherapies. The mechanisms of CSC-mediated therapy resistance are not fully understood. However, they include different strategies used by CSCs to overcome challenges imposed by treatment, such as activation of DNA repair system, anti-apoptotic mechanisms, acquisition of quiescent state and Epithelial-mesenchymal transition, increased drug efflux capacity, hypoxic environment, protection by the CSC niche, overexpression of stemness related genes, and immune surveillance. Complete elimination of CSCs seems to be the main target for achieving tumor control and improving overall survival for cancer patients. This review will focus on the multi-factorial mechanisms by which CSCs are resistant to radiotherapy and chemotherapy in HNSCC, supporting the use of possible strategies to overcome therapy failure.

show abstract

Hypoxia induces radioresistance, epithelial‑mesenchymal transition, cancer stem cell‑like phenotype and changes in genes possessing multiple biological functions in head and neck squamous cell carcinoma

Cited by 14 publications

References 57 publications

The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

The prevalence and genetic disorders spectrum of thalassemia among breast cancer patients in Jiangxi province, China

Identity matters: cancer stem cells and tumour plasticity in head and neck squamous cell carcinoma

Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

Contact Info

Product

Resources

About