Hypoxia‐induced microRNA‐301b regulates apoptosis by targeting Bim in lung cancer

Wu, Duoguang; Chen, Baishen; Cui, Fei; He, Xiaotian; Wang, Wenjian; Wang, Minghui

doi:10.1111/cpr.12264

Cited by 39 publications

(37 citation statements)

References 29 publications

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“…Scale bar: 50 μm hepatoblastoma and pancreatic cancer cells 15,20,31,32. Furthermore, miR-301b-3p promotes the proliferation and inhibits apoptosis of breast cancer, melanoma, hepatoblastoma, bladder cancer and lung cancer cells 18,21,23,31,34. All these studies support the onco-…”

mentioning

confidence: 54%

“…Furthermore, increased expression of miR‐301b‐3p indicates poor survival of patients with pancreatic cancer, and contributes to epithelial‐to‐mesenchymal transition (EMT) and cancer cell resistance to the gemcitabine by targeting nuclear receptor subfamily 3 group C member 2 (NR3C2) . Overexpression of miR‐301b‐3p is a frequently even in lung cancer and facilitates cell growth, apoptosis resistance and resistance of cells to chemotherapy via suppressing Bim . Moreover, miR‐301b‐3p functions as an oncogene in pancreatic cancer via contributing to cell migration, invasion and gemcitabine resistance by targeting TP63 .…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA‐301b‐3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4

Guo

Yao

Zhu

et al. 2019

J Cellular Molecular Medi

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Micro RNA s (mi RNA s) are key regulators in the tumour growth and metastasis of human hepatocellular carcinoma ( HCC ). Increasing evidence suggests that miR‐301b‐3p functions as a driver in various types of human cancer. However, the expression pattern of miR‐301b‐3p and its functional role as well as underlying molecular mechanism in HCC remain poorly known. Our study found that miR‐301b‐3p expression was significantly up‐regulated in HCC tissues compared to adjacent non‐tumour tissues. Clinical association analysis revealed that the high level of miR‐301b‐3p closely correlated with large tumour size and advanced tumour‐node‐metastasis stages. Importantly, the high miR‐301b‐3p level predicted a prominent poorer overall survival of HCC patients. Knockdown of miR‐301b‐3p suppressed cell proliferation, led to cell cycle arrest at G2/M phase and induced apoptosis of Huh7 and Hep3B cells. Furthermore, miR‐301b‐3p knockdown suppressed tumour growth of HCC in mice. Mechanistically, miR‐301b‐3p directly bond to 3′ UTR of vestigial like family member 4 ( VGLL 4) and negatively regulated its expression. The expression of VGLL 4 mRNA was down‐regulated and inversely correlated with miR‐301b‐3p level in HCC tissues. Notably, VGLL 4 knockdown markedly repressed cell proliferation, resulted in G2/M phase arrest and promoted apoptosis of HCC cells. Accordingly, VGLL 4 silencing rescued miR‐301b‐3p knockdown attenuated HCC cell proliferation, cell cycle progression and apoptosis resistance. Collectively, our results suggest that miR‐301b‐3p is highly expressed in HCC . miR‐301b‐3p facilitates cell proliferation, promotes cell cycle progression and inhibits apoptosis of HCC cells by repressing VGLL 4.

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mentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

MicroRNA‐301b‐3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4

Guo

Yao

Zhu

et al. 2019

J Cellular Molecular Medi

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“…Several of these miRNAs have been previously associated with the molecular mechanisms of tumors. In lung cancer, high expression of miR‐301b is known to modulate FOXF2, and ectopic expression of its 3′‐untranslated region (3′‐UTR) reduced the sensitivity of cells to chemotherapy . miR‐383 is an inhibitor of lung cancer, which can target the 3′UTR of endothelial PAS domain protein 1 mRNA, which is significantly associated with poor prognosis in patients .…”

Section: Discussionmentioning

confidence: 99%

“…In lung cancer, high expression of miR-301b is known to modulate FOXF2, and ectopic expression of its 3′untranslated region (3′-UTR) reduced the sensitivity of cells to chemotherapy. 27,28 miR-383 is an inhibitor of lung cancer, which can target the 3′UTR of endothelial PAS domain protein 1 mRNA, which is significantly associated with poor prognosis in patients. 29,30 Expression of miR-448 has been linked to the molecular mechanisms of various tumors, such as LUSC, 31 osteosarcoma, 32 pancreatic ductal adenocarcinoma, 33 colorectal cancer, 34 breast cancer, 35,36 and others.…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs associated with lung squamous cell carcinoma: New prognostic biomarkers and therapeutic targets

Gao

Feng

et al. 2019

J of Cellular Biochemistry

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Background With the development in research, the importance of microRNAs (miRNAs) in the occurrence and metastasis, and prognosis of lung squamous cell carcinoma (LUSC) have received extensive attention. This study aims to identify new biomarkers and pivotal genes associated with LUSC prognosis through bioinformatics. Materials and methods We downloaded miRNA and messenger RNA samples related to LUSC from The Cancer Genome Atlas (TCGA) database. Following initial data screening and preprocessing, we utilized the R platform and a range of analysis tools (miRDB, TargetScanHuman7.2, DAVID, and Cytoscape_v3.5.1) to analyze the TCGA data and identify highly specific and sensitive biomarkers. Results We finally identified 12 miRNAs and six central genes closely related to the overall survival of patients with LUSC. We found that high expression of 7 miRNAs (miR‐301b, miR‐383, miR‐512, miR‐515, miR‐525, miR‐577, and miR‐5682) and low expression of five miRNAs (miR‐448, miR‐486, miR‐4732,miR‐4732, miR‐516, and miR‐1911) can significantly improve the overall survival rate of patients with LUSC. The six central genes DLGAP5, CENPA, CHEK1, LRRK2, CALB1, and TOP2A are directly or indirectly involved in the formation and metastasis of LUSC and could, therefore, be considered as target genes for drug therapy. Conclusion With the development in research, the importance of miRNAs in the occurrence and metastasis and prognosis of LUSC have received extensive attention. This study aims to identify new biomarkers and pivotal genes associated with LUSC prognosis through bioinformatics.

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“…This is made possible by a cellular HIF system. Cellular hypoxia, or a lower than "normal" concentration of O 2 in cells, occurs commonly and could induce signiicant changes, immediate or delayed, on cellular processes, including cell growth and apoptosis, cell proliferation and survival, pH regulation and energy metabolism, cell migration, matrix and barrier function, angiogenesis, and vasomotor regulation [8][9][10][11][12][13]. These biological processes involve active responses by the body to secure an additional oxygen supply via circulation.…”

Section: Hypoxia In the Oral/periodontal Environmentmentioning

confidence: 99%

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

Wang¹,

Chen²,

Leung³

2017

Hypoxia and Human Diseases

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Human periodontitis is a chronic inlammatory disease induced by opportunistic Gramnegative anaerobic bacteria at the tooth-supporting apparatus. Within the gingivitisafected sulcus or periodontal pocket, the resident anaerobic bacteria interact with the host inlammatory reactions leading to a lower oxygen or hypoxic environment. A cellular/tissue oxygen-sensing mechanism and its appropriate regulation are needed to assist tissue adaptation to natural/pathology-induced variations in oxygen availability. In this chapter, we reviewed the biological relevance of hypoxia in periodontal/oral cellular development, epithelial barrier function, periodontal inlammation, and immunity. The role of hypoxia-inducible factor-1α in pathogen-host cross talk and alveolar bone homeostasis was also discussed. The naturally occurring pathophysiological process of hypoxia appeared to entail fundamental relevance for periodontal defense and regeneration.

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Hypoxia‐induced microRNA‐301b regulates apoptosis by targeting Bim in lung cancer

Abstract: This study provides new insights into the function of miRNA-301b in lung cancer and suggests that miRNA-301b could be a potential molecular target for chemotherapy.

Cited by 39 publications

References 29 publications

MicroRNA‐301b‐3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4

MicroRNA‐301b‐3p contributes to tumour growth of human hepatocellular carcinoma by repressing vestigial like family member 4

MicroRNAs associated with lung squamous cell carcinoma: New prognostic biomarkers and therapeutic targets

Role of the Hypoxia-Inducible Factor in Periodontal Inflammation

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