Hypoxia induced cognitive impairment modulating activity of Cyperus rotundus

Traditional Herbal Medicines Against CNS Disorders from Bangladesh

“…Gandhi Kundri Shrub Leaves Epilepsy, mental disorder NRE [ 89 ] Trichosanthes bracteata (Lam.) Voigt Makalphal Climber Fruit, seed Headache NRE [ 97 ] Trichosanthes cucumerina L. Chichinga Climber Fruit, seed Headache NRE [ 129 ] Cyperaceae Cyperus rotundus L. Mutha, Takudare (Sa) Graminoid Root Paralysis, (Sa) Modulate memory impairment [ 175 , 176 ] Dilleniaceae Dillenia indica L. Chalta Tree Fruit Epilepsy, headache Inhibit diabetic neuropathic pain [ 114 , 177 , 178 ] Dioscoreaceae Dioscorea bulbifera L. Banalu Climber Aerial part, tuber Headache NRE [ 101 ] Dioscorea pentaphylla L. Thubri Vine Leaves Paralysis NRE [ 114 ...…”

Protection of Episodic Memory by Neuroprotective Peptide Treatments in Sprague-Dawley Rats Subjected to Hypoxic Exposure

“…Studies of spatial, visual, and working memory deficits following hypoxic exposures have been demonstrated using the Morris water maze. Exposure conditions include acute and continuous [38], chronic continuous [39][40][41][42][43], acute intermittent [44], and oscillating, chronic intermittent [45,46]. Hypoxiainduced memory dysfunction has also been demonstrated using a radial-arm maze [47], and an object displacement/replacement test [48] that is similar to the NOR test used in this study.…”

“…area of active research [59,60]. A variety of agents, including organic compounds [38,44,61], neurohormones [62,63], plant extracts [41][42][43]64], cellular proteins [65][66][67][68][69][70], growth factors [71][72][73][74], peptides [30][31][32][33][34][35][36][37]75] and small interfering RNA [45,46] have shown different levels of neuroprotective activities under hypoxic conditions.…”

Peer Review #1 of "Experimental lung injury induces cerebral cytokine mRNA production in pigs (v0.1)"

“…The underlying pathophysiological mechanisms are poorly understood, but are likely complex and multifactorial. Global hypoxia (Kandikattu et al 2017), inflammation (Dantzer et al 2008), oxidative stress (Popa-Wagner et al 2013), and autonomic nervous system dysregulation (Gonzalez-Lopez et al 2013) constitute proposed mechanisms. Of note, even mechanical ventilation alone leads to hippocampal apoptosis and could contribute to the cognitive decline (Gonzalez-Lopez et al 2013).…”