Hypoxia-improving strategy based on human-derived hemoglobin-based oxygen carriers for breast cancer monitored in vivo by functional photoacoustic mesoscopy
Yuxuan Qin,
Yipin Lv,
Pengwei Han
et al.
Abstract:Hypoxia in malignant tumors can have an inhibitory effect on photodynamic therapy, chemotherapy, radiotherapy, immunotherapy, and chemodynamic therapy. In previous studies, nanoparticle platforms combined with drugs or direct oxygen-carrying to increase oxygen content are usually used. Here, we designed to improve tumor hypoxia by injecting human-derived hemoglobin-based oxygen carriers (h-HBOC) synthesized from expired human blood or human placental blood, and real-time quantitative oxygen concentration monit… Show more
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