Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback

Prokkola, Jenni M.; Nikinmaa, Mikko; Lubiana, Pedro; Kanerva, Mirella; McCairns, R. J. Scott; Götting, Miriam

doi:10.1016/j.aquatox.2014.11.006

Cited by 27 publications

(14 citation statements)

References 63 publications

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“…For example, similar dissolved oxygen × chemical experiments with ammonia, 1,2,4‐trichlorobenzene, sweet crude oil, cadmium, and copper in Daphnia and several fish species (Carlson ; Dasgupta et al ; Fitzgerald et al ; Hattlink et al ; Lyu et al ) have been shown to decrease survival, which are consistent with our observations. At the subcellular level, hypoxia and the pharmaceutical diclofenac were shown to induce CYP1A activity (ethoxyresorufin‐O‐deethylase) above diclofenac activity alone in the 3‐spined stickleback, which is the opposite of other studies predominantly reporting an inhibitory effect on CYP1A activity (Matson et al ; Prokkola et al ; Rahman and Thomas ). Conversely, lactate dehydrogenase increased in response to hypoxia but was suppressed to control levels after co‐exposures.…”

Section: Discussioncontrasting

confidence: 67%

“…Understanding aquatic responses to chemical and nonchemical stressors was recently highlighted as a priority research question to understand risks of pharmaceuticals in the environment (Boxall et al ). Fish responses to chemical stressors (e.g., ammonia, metals, and polycyclic aromatic hydrocarbons [PAHs]) have been shown to be influenced by low DO (Fleming and Di Giulio ; Hattlink et al ; Lyu et al ; Matson et al ; Prokkola et al ). Recently, our group and others have observed concentrations of the calcium channel blocker (CCB) diltiazem in fish plasma, and in some cases these observations were approaching and even exceeding human therapeutic plasma levels (Du et al ; Fick et al ; Scott et al ; Tanoue et al ).…”

Section: Introductionmentioning

confidence: 99%

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Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients

Saari

Corrales

Haddad

et al. 2018

Enviro Toxic and Chemistry

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Water resources in many arid to semi-arid regions are stressed by population growth and drought. Growing populations and climatic changes are influencing contaminant and water chemistry dynamics in urban inland waters, where flows can be dominated by, or even dependent on, wastewater effluent discharge. In these watersheds, interacting stressors such as dissolved oxygen and environmental contaminants (e.g., pharmaceuticals) have the potential to affect fish physiology and populations. Recent field observations from our group identified the calcium channel blocker (CCB) diltiazem in fish plasma exceeding human therapeutic doses (e.g., C ) in aquatic systems impaired because of nonattainment of dissolved oxygen water quality standards. Therefore our study objectives examined: 1) standard acute and chronic effects of dissolved oxygen and diltiazem to fish, 2) influences of dissolved oxygen at criteria levels deemed protective of aquatic life on diltiazem toxicity to fish, and 3) whether sublethal effects occur at diltiazem water concentrations predicted to cause a human therapeutic level (therapeutic hazard value [THV]) in fish plasma. Dissolved oxygen × diltiazem co-exposures significantly decreased survival at typical stream, lake, and reservoir water quality standards of 5.0 and 3.0 mg dissolved oxygen/L. Dissolved oxygen and diltiazem growth effects were observed at 2 times and 10 times lower than median lethal concentration (LC50) values (1.7 and 28.2 mg/L, respectively). Larval fathead minnow (Pimephales promelas) swimming behavior following low dissolved oxygen and diltiazem exposure generally decreased and was significantly reduced in light-to-dark bursting distance traveled, number of movements, and duration at concentrations as low as the THV. Individual and population level consequences of such responses are not yet understood, particularly in older organisms or other species; however, these findings suggest that assessments with pharmaceuticals and other cardioactive contaminants may underestimate adverse outcomes in fish across dissolved oxygen levels considered protective of aquatic life. Environ Toxicol Chem 2018;37:2835-2850. © 2018 SETAC.

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Section: Discussioncontrasting

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients

Saari

Corrales

Haddad

et al. 2018

Enviro Toxic and Chemistry

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“…CYP1A activity shows daily variation in the liver of the threespine stickleback under control conditions (Fig. 5), either as a result of direct interaction between AhR and circadian clock pathways or owing to other metabolic interactions (Prokkola et al, 2015).…”

Section: Toxic Chemicals and Their Effects Upon Circadian Rhythmsmentioning

confidence: 99%

“…transcription of rhythm-generating genes in zebrafish (Zhao et al, 2015) and wastewater treatment plant effluent can reduce circadian oscillation in the activity of male mosquitofish (Melvin et al, 2016). In addition, the anti-inflammatory drug diclofenac disturbs the temporal patterns of transcription of rhythm-generating genes and, for example, lactate dehydrogenase activity, in three-spined stickleback (Lubiana et al, 2016;Prokkola et al, 2015). Hence, ecotoxicological research can provide valuable insight on the importance of circadian rhythms across tissues in fish.…”

Section: Toxic Chemicals and Their Effects Upon Circadian Rhythmsmentioning

confidence: 99%

“…This practice can lead to a situation where variation that can be dramatic and important for the investigated physiological or behavioural response is ignored. Although multiple sampling time points across several daily cycles are therefore recommended, even three time points can indicate whether important variation is ignored if the study setup is limited to a single time point, as shown in Healy and Schulte (2012), Lewis et al (2016), Lubiana et al (2016) and Prokkola et al (2015Prokkola et al ( , 2018.…”

Section: Toxic Chemicals and Their Effects Upon Circadian Rhythmsmentioning

confidence: 99%

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Circadian rhythms and environmental disturbances – underexplored interactions

Prokkola

Nikinmaa

2018

Journal of Experimental Biology

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Biological rhythms control the life of virtually all organisms, impacting numerous aspects ranging from subcellular processes to behaviour. Many studies have shown that changes in abiotic environmental conditions can disturb or entrain circadian (∼24 h) rhythms. These expected changes are so large that they could impose risks to the long-term viability of populations. Climate change is a major global stressor affecting the fitness of animals, partially because it challenges the adaptive associations between endogenous clocks and temperature - consequently, one can posit that a large-scale natural experiment on the plasticity of rhythm-temperature interactions is underway. Further risks are posed by chemical pollution and the depletion of oxygen levels in aquatic environments. Here, we focused our attention on fish, which are at heightened risk of being affected by human influence and are adapted to diverse environments showing predictable changes in light conditions, oxygen saturation and temperature. The examined literature to date suggests an abundance of mechanisms that can lead to interactions between responses to hypoxia, pollutants or pathogens and regulation of endogenous rhythms, but also reveals gaps in our understanding of the plasticity of endogenous rhythms in fish and in how these interactions may be disturbed by human influence and affect natural populations. Here, we summarize research on the molecular mechanisms behind environment-clock interactions as they relate to oxygen variability, temperature and responses to pollutants, and propose ways to address these interactions more conclusively in future studies.

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The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure

Wang

Zhou

et al. 2019

Mol Biol Rep

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Hypoxia and the pharmaceutical diclofenac influence the circadian responses of three-spined stickleback

Cited by 27 publications

References 63 publications

Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients

Influence of Diltiazem on Fathead Minnows Across Dissolved Oxygen Gradients

Circadian rhythms and environmental disturbances – underexplored interactions

The transcriptomic responses of the ark shell, Anadara broughtonii, to sulfide and hypoxia exposure

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