Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups

Avci, Aynur Yilmaz; Avci, Suat; Lakadamyalı, Hatıce; Can, Ufuk

doi:10.1007/s11325-017-1486-5

Cited by 44 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…40 In addition, SDB, hypoxemia and inflammation were associated with WMH in people with SDB. 41 In contrast, some studies indicate a lack of association between SDB and WMH. For instance, in a study of hypertensive patients, researchers did not find that severity of SDB was associated with white matter disease based on a visual rating scale.…”

Section: Discussionmentioning

confidence: 99%

The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients

et al. 2018

View full text Add to dashboard Cite

Heart failure patients often manifest white matter hyperintensites on brain magnetic resonance imaging (MRI). White matter hyperintnsities have also been linked with cognitive problems in patients with heart failure. Sleep disordered breathing may contribute to structural brain changes in heart failure. The purpose of this study was to test the extent to which the apnea hypopnea index is associated with global and regional white matter hyperintensities, and is a moderating factor in the relationship between age and white matter hyperintensites. A total of 28 HF patients [mean age (SD) = 67.89 (5.8)] underwent T1-weighted and T2FLAIR MRI and a home sleep monitoring study. The apnea hypopnea index cut off of 10 was used to compare between higher and lower risks of sleep disordered breathing. Regression analysis was used to test the association between apnea hypopnea index and both global and regional white matter hyperintensities. The interaction term was entered to identify the moderation effect. Apnea hypopnea index was associated with higher regional white matter hyperintensities but not global white matter hyperintensities. There was a significant interaction between the apnea hypopnea index and age, such that older participants with the apnea hypopnea index ≥10 showed greater regional white matter hyperintensities than those with the apnea hypopnea index <10. The results of this preliminary study indicate that a higher apnea hypopnea index is associated with more white matter hyperintensities. The age-related white matter hyperintensities appear to be exacerbated by apnea hypopnea index in our individuals with heart failure. Future studies are needed to further investigate the underlying mechanisms.

show abstract

Section: Discussionmentioning

confidence: 99%

The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Lowest oxygen saturation is known to be well correlated with the severity of OSA, as measured by the AHI [ 16 ]. However, AHI was not significantly changed in our study.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lifestyle Modification Using a Smartphone Application on Obesity With Obstructive Sleep Apnea: A Short-term, Randomized Controlled Study

Cho

Wee

Yoo

et al. 2018

Clin Exp Otorhinolaryngol

View full text Add to dashboard Cite

ObjectivesTo investigate the short-term effects of a lifestyle modification intervention based on a mobile application (app) linked to a hospital electronic medical record (EMR) system on weight reduction and obstructive sleep apnea (OSA).MethodsWe prospectively enrolled adults (aged >20 years) with witnessed snoring or sleep apnea from a sleep clinic. The patients were randomized into the app user (n=24) and control (n=23) groups. The mobile app was designed to collect daily lifestyle data by wearing a wrist activity tracker and reporting dietary intake. A summary of the lifestyle data was displayed on the hospital EMR and was reviewed. In the control group, the lifestyle modification was performed as per usual practice. All participants underwent peripheral arterial tonometry (WatchPAT) and body mass index (BMI) measurements at baseline and after 4 weeks of follow-up.ResultsAge and BMI did not differ significantly between the two groups. While we observed a significant decrease in the BMI of both groups, the decrease was greater in the app user group (P <0.001). Apnea-hypopnea index, respiratory distress index, and oxygenation distress index did not change significantly in both groups. However, the proportion of sleep spent snoring at >45 dB was significantly improved in the app user group alone (P =0.014). In either group, among the participants with successful weight reduction, the apnea-hypopnea index was significantly reduced after 4 weeks (P =0.015). Multiple regression analyses showed that a reduction in the apnea-hypopnea index was significantly associated with BMI.ConclusionAlthough a short-term lifestyle modification approach using a mobile app was more effective in achieving weight reduction, improvement in OSA was not so significant. Long-term efficacy of this mobile app should be evaluated in the future studies.

show abstract

“…The main mechanisms of OSAS are hypoxia and oxidative stress; however, several studies have demonstrated that inflammation also plays a crucial role in the occurrence and development of OSAS [ 14 ]. Systemic and local inflammation in OSAS patients manifests as a result of chronic intermittent hypoxemia (CIH) [ 11 , 15 ], snoring [ 16 ], continuous hypoxia [ 17 ], oxidative stress, and sleep fragmentation and deprivation [ 18 – 20 ]. In the last two decades, many studies have investigated the precise interactions between OSAS and inflammation in both adults and children, and some studies have tried to elucidate the potential biomarkers in the presence of OSAS and OSAS-related morbidities [ 21 – 23 ].…”

Section: Inflammation In Osasmentioning

confidence: 99%

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Liu

Ouyang

et al. 2020

J Neuroinflammation

108

View full text Add to dashboard Cite

Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), leading to cognitive dysfunction, a significant and extraordinary complication of OSAS patients. The repeated courses of airway collapse and obstruction in OSAS patients resulted in apnea and arousal during sleep, leading to IH and excessive daytime sleepiness (EDS) and subsequently contributing to the development of inflammation. IH-mediated inflammation could further trigger various types of cognitive dysfunction. Many researchers have found that, besides continuous positive airway pressure (CPAP) treatment and surgery, anti-inflammatory substances might alleviate IH-induced neurocognitive dysfunction. Clarifying the role of inflammation in IH-mediated cognitive impairment is crucial for potentially valuable therapies and future research in the related domain. The objective of this article was to critically review the relationship between inflammation and cognitive deficits in OSAS.

show abstract

Hypoxia and inflammation indicate significant differences in the severity of obstructive sleep apnea within similar apnea-hypopnea index groups

Cited by 44 publications

References 31 publications

The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients

The association of sleep-disordered breathing and white matter hyperintensities in heart failure patients

Effect of Lifestyle Modification Using a Smartphone Application on Obesity With Obstructive Sleep Apnea: A Short-term, Randomized Controlled Study

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Contact Info

Product

Resources

About