Hypovolemic state: Involvement of nitric oxide in the aged related alterations of aquaporins-2 abundance in rat kidney

Arreche, Noelia; Fellet, Andrea L.; López, Margarita; López‐Costa, Juan José; Arranz, Cristina; Balaszczuk, Ana M.

doi:10.1016/j.vph.2008.04.001

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Additionally, a similar relationship between NO and AQP2 water channel has also been found in the inner medulla, but in this case in an experimental model of hypovolemia induced by hemorrhage [32]. Thus, NO levels would be involved into the potential linkage between aging, hypothyroidism and water handling.…”

Section: Discussionsupporting

confidence: 72%

Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

et al. 2013

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Section: Discussionsupporting

confidence: 72%

Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

et al. 2013

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“…During aging, significant increases in advanced glycosylation end products (AGE) and other oxidants have been reported in kidneys [ 115 , 116 ]. Chronic inhibition of nitric oxidase synthase regulates renal water balance by reducing the expression of AQP2 [ 117 , 118 ]. Importantly, oxidative stress is often associated with disorders linked to redox unbalance.…”

Section: Role Of Vasopressin/aqp2 Axis and Oxidative Stress In Agimentioning

confidence: 99%

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

Tamma

Valenti

Grossini

et al. 2018

Oxidative Medicine and Cellular Longevity

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Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis. Extensive investigation aims to elucidate the beneficial effects of ROS and NO, providing novel insights into the current medical treatment of oxidative stress-related diseases of high epidemiological impact. This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. The most recent advances regarding the modulation exerted by food phytocompounds with antioxidant action on AQPs are also reviewed.

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“…Additionally, focusing on NO system, it has also been reported that NO is involved in regulation of AQPs abundance and trafficking. Previous results from our laboratory in renal tissue indicated that NO system decreased AQP2 expression levels and its apical localization during hypovolemic state [12]. Moreover, it has been described that NO also affects AQP5 membrane insertion in epithelial pulmonary cells [13].…”

Section: Introductionmentioning

confidence: 76%

Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart

Netti

Iovane

Vatrella

et al. 2016

Biomedicine & Pharmacotherapy

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Hypovolemic state: Involvement of nitric oxide in the aged related alterations of aquaporins-2 abundance in rat kidney

Cited by 8 publications

References 22 publications

Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

Nitric oxide and AQP2 in hypothyroid rats: A link between aging and water homeostasis

Aquaporin Membrane Channels in Oxidative Stress, Cell Signaling, and Aging: Recent Advances and Research Trends

Effects of nitric oxide system and osmotic stress on Aquaporin-1 in the postnatal heart

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