Hypovolemia, pulmonary edema and protein changes in severe salicylate poisoning

Hormaechea, Enrique; Carlson, Richard W.; Rogove, Herbert J.; Uphold, John; Henning, Robert J.; Weil, Max Harry

doi:10.1016/0002-9343(79)90463-7

Cited by 38 publications

(2 citation statements)

References 13 publications

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“…Salicylate‐induced pulmonary edema has been observed in humans [24–29] and studied in animals [30,31]. The human observations indicate noncardiogenic pulmonary edema with low cardiac filling pressures and a high protein, transudative fluid in the airways [27]. Animal studies also indicate that salicylate toxicity causes increased pulmonary vascular permeability, whereas pulmonary vascular pressure and cardiac performance are unaffected [30,31].…”

Section: Pathophysiologymentioning

confidence: 99%

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Salicylate Intoxication

Yip

Jastremski

Dart

1997

J Intensive Care Med

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Aspirin (acetylsalicylic acid) is one of the most widely used over‐the‐counter medications. Because of its availability and widespread use, aspirin has a long history of human toxicity from accidental or intentional overdosing. According to the American Association of Poison Control Centers aspirin was implicated in 19083 exposures in 1995, with 11800 cases treated in a health care facility, and 52 associated deaths. Aspirin toxicity may be a life‐threatening condition that produces multiple system organ failure requiring treatment in an intensive care unit. Managing a patient with salicylism will challenge the skills of the critical care team, especially in the areas of life support, fluid and electrolyte balance, and acid‐base management. This article reviews the physiology, pathophysiology, acute and chronic salicylism in children and adults, and management of salicylate intoxication.

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Section: Pathophysiologymentioning

confidence: 99%

“…This vascular injury may extend to the kidneys. Proteinuria is a prominent early finding in salicylate toxicity, starting at serum salicylate levels greater than 30 mg/dL, and it is directly related to salicylate levels [27].…”

Section: Pathophysiologymentioning

confidence: 99%