Hypovitaminosis Din Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

Chen, Jen-Yin; Lin, Yuan‐Yung; Wang, Li‐Kai; Hung, Kuo‐Chuan; Lan, Kuo-Mao; Ho, Chung‐Han; Chang, Chia Yu

doi:10.3390/nu11112787

Cited by 13 publications

(14 citation statements)

References 65 publications

(127 reference statements)

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“…Third, a previous study based on the Douleur Neuropathique 4 questionnaire discovered that hypovitaminosis D was associated with increased spontaneous and brush-evoked pain. The patients with vitamin D <67.0 nmol/L were more likely to suffer from spontaneous painful cold [ 47 ]. It seems that there are associations between nutritional deficiency and sensory symptoms/signs.…”

Section: Discussionmentioning

confidence: 99%

Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia

et al. 2020

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Vitamin C deficiency increases the risk of postherpetic neuralgia (PHN). In this cross-sectional study, the relationships among plasma vitamin C concentrations, pain and Leeds assessment of neuropathic symptoms and signs (LANSS) items were investigated during their first pain clinic visit of 120 PHN patients. The factors associated with vitamin C deficiency were determined. Independent predictors of vitamin C deficiency were presented as adjusted odds ratios (AOR) and 95% confidence intervals (CI). The patients had a high prevalence (52.5%) of vitamin C deficiency. Their plasma vitamin C concentrations were negatively associated with spontaneous pain and tingling, prickling or pins and needles sensation according to the LANSS questionnaire. Based on the receiver operator characteristic curve, the cutoffs for plasma vitamin C to predict moderate-to-severe and severe symptoms of sharp sensation were <7.05 and <5.68 mg/L, respectively. By comparison, the patients well-nourished with vitamin C had lower incidences of sharp sensations, sharp pain, and reddish skin. Multivariate analyses revealed that vitamin C deficiency was associated with the low intake of fruit/vegetables (AOR 2.66, 95% CI 1.09–6.48, p = 0.032), peptic ulcer disease (AOR 3.25, 95% CI 1.28–8.28, p = 0.014), and smoking (AOR 3.60, 95% CI 1.33–9.77, p = 0.010). Future studies are needed to substantiate these findings.

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Section: Discussionmentioning

confidence: 99%

Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia

et al. 2020

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“…The serum sample, which was acquired from a fasting blood sample of each subject after centrifugation and stored at a temperature of −70 °C, was subject to serum 25(OH)D quantification using automated Chemiluminescent Microparticle Immuno Assay [ 5 , 32 ] (ARCHITECTi2000 (Abbott, Chicago, IL, USA) as our previous study [ 5 ].…”

Section: Methodsmentioning

confidence: 99%

“…During the past decades, associations between vitamin D status and extra-skeletal health have been recognized. Vitamin D status is highly associated with the risks of autoimmune diseases [ 1 ], metabolic syndrome [ 2 , 3 ] and neuropathic pain [ 4 , 5 ]. Serum 25-hydroxyvitamin D (25(OH)D) is generally used as a marker of vitamin D status [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region

et al. 2020

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This study aimed at determining the prevalence and predictors of hypovitaminosis D (serum 25-hydroxyvitamin D < 30 ng/mL) among office workers in a subtropical region from an electronic hospital database. Totally, 2880 office workers aged 26–65 years who received health examinations with vitamin D status and total calcium concentrations at a tertiary referral center were retrospectively reviewed. Subjects were divided into groups according to genders, age (i.e., 26–35, 36–45, 46–55, 56–65), body-mass index (BMI) (i.e., obese BMI ≥ 30, overweight 25 ≤ BMI < 30, normal 20 ≤ BMI < 25, and underweight BMI < 20) and seasons (spring/winter vs. summer/autumn) for identifying the predictors of hypovitaminosis D. Corrected total calcium level <8.4 mg/dL is considered as hypocalcemia. Multivariate logistic regression demonstrated that females (AOR 2.33, (95% CI: 1.75, 3.09)), younger age (4.32 (2.98, 6.24), 2.82 (1.93, 4.12), 1.50 (1.03, 2.17)), and season (winter/spring) (1.55 (1.08, 2.22)) were predictors of hypovitaminosis D, whereas BMI was not in this study. Despite higher incidence of hypocalcemia in office workers with hypovitaminosis D (p < 0.001), there was no association between vitamin D status and corrected total calcium levels. A high prevalence (61.9%) of hypovitaminosis D among office workers in a subtropical region was found, highlighting the importance of this occupational health issue.

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“…Vitamin D can inhibit neuroinflammation through down-regulation of pro-inflammatory cytokines and up-regulation of anti-inflammatory cytokines. Chen et al showed in their study that hypovitaminosis D was significantly higher in postherpetic neuralgia patients compared to controls [15]. In a study by Han et al with 30 zoster patients, the incidence of herpes zoster decreased as 25 hydroxyvitamin D3 increased [16].…”

Section: Discussionmentioning

confidence: 91%

Assessment of vitamin D levels in zona zoster

dere¹,

Öztürk²

2021

Preprint

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Aim: Vitamin D affects the secretion of antimicrobial peptides associated with toll-like receptor (TLR), which have antiviral effects. It has been suggested that vitamin D may affect the susceptibility of the host to varicella zoster virus (VZV) and the clinical course of zona zoster. Materials and Methods: In this study, 101 patients who were diagnosed with zona zoster at the dermatology outpatient clinic and had a vitamin D result at the time of diagnosis and a control group of 100 people were included. Results were analyzed statistically. Results: The 25-OH vitamin D levels of the patients ranged from 2.37 to 32.98 µg / L and the mean value was 14.25 ± 7.20 µg / L. In the control group, 25-OH vitamin D levels ranged between 10.3 and 44.25 µg / L, and the mean value was 24.9 ± 6.24 µg / L. 25-OH vitamin D levels in the patient group were significantly lower than the levels in the control group. (p <0.001) Conclusion: This study revealed that 25-OH vitamin D levels were significantly lower in patients with zona zoster compared to the control group. 25-OH vitamin D deficiency may increase the risk of VZV reactivation, and vitamin D supplementation in patients with vitamin D deficiency in zona zoster may help the mild course of the disease.

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Hypovitaminosis Din Postherpetic Neuralgia—High Prevalence and Inverse Association with Pain: A Retrospective Study

Cited by 13 publications

References 65 publications

Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia

Plasma Vitamin C Concentrations Were Negatively Associated with Tingling, Prickling or Pins and Needles Sensation in Patients with Postherpetic Neuralgia

Age, Gender and Season Are Good Predictors of Vitamin D Status Independent of Body Mass Index in Office Workers in a Subtropical Region

Assessment of vitamin D levels in zona zoster

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