Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?

Arabi, Asma; Baddoura, Rafic; Awada, H; Salamoun, Mariana; Ayoub, Ghazi; Fuleihan, Ghada El‐Hajj

doi:10.1016/j.bone.2006.01.140

Cited by 49 publications

(46 citation statements)

References 36 publications

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“…A positive correlation between 25(OH)D and spine, but not hip BMD (Z-score) was noted in postmenopausal Iranian women [118]. Similar correlations were noted in elderly Lebanese with spine, hip, and forearm BMD (R = 0.13-0.3) but were not present after adjustment for age, height, lean mass, and PTH levels [102], consistent with findings in Iranian women [116]. Neonatal size or bone mass may be affected by maternal vitamin D status [87].…”

Section: Middle East and Africasupporting

confidence: 52%

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Global vitamin D status and determinants of hypovitaminosis D

Wahl²,

et al. 2009

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Section: Middle East and Africasupporting

confidence: 52%

“…The mean 25(OH)D level was near 25 nmol/L in Lebanese, Saudi, Emirati, and Iranian women [98][99][100][101]. A similar mean was recorded in elderly Lebanese [102]. The proportion of subjects with vitamin D levels below specific cut-offs varied.…”

Section: Middle East and Africamentioning

confidence: 82%

Global vitamin D status and determinants of hypovitaminosis D

Wahl²,

et al. 2009

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“…People living in sunny countries have always been considered at lower risk of hypovitaminosis D. Nevertheless, a high prevalence of vitamin D deficiency has been reported in Lebanon (Gannage-Yared et al, 2000;El-Hajj Fuleihan et al, 2001;Arabi et al, 2006). Whether some VDR genotypes show resistance to cutaneous production of vitamin D and therefore have a role in this unexpected high prevalence of vitamin D deficiency has been analyzed in limted studies.…”

Section: Discussionmentioning

confidence: 99%

“…The relationship between 25-OHD and bone mass was previously published (Arabi et al, 2006). 25-OHD correlated with BMD at multiple skeletal levels (Arabi et al, 2006).…”

Section: Findings In the Elderlymentioning

confidence: 91%

“…Recently, our group showed that the deleterious effect of hypovitaminosis D on bone may in large part be mediated through lean mass and PTH (Arabi et al, 2006). VDR is widely expressed in muscle and parathyroid glands, but it is unclear whether the relationship between VDR genotypes and bone mass is mediated through an effect on lean mass, PTH, or both.…”

Section: Introductionmentioning

confidence: 99%

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Effect of age, gender and calciotropic hormones on the relationship between vitamin D receptor gene polymorphisms and bone mineral density

et al. 2010

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Background/Objectives: Hypovitaminosis D is a major public health problem worldwide and unexpectedly more so in sunny countries. Vitamin D receptor (VDR) gene is associated with inter-individual variance in bone mineral density (BMD). Studies assessing the effect of VDR gene polymorphisms on BMD yielded conflicting results. The aim of this study was to assess the relationship between VDR polymorphisms and BMD in the Lebanese, across age groups and genders and to assess the effect of PTH and lean mass and vitamin D levels on such relationship. Subjects/Methods: In total, 203 subjects aged 65-85 years and 336 children aged 10-17 years. Polymorphisms in the VDR gene were assessed with the restriction enzymes BsmI, TaqI and ApaI. Bone mineral content, BMD and lean mass were measured using Dual-Energy X-ray Absorptiometry (DXA). The dominant hand strength was measured in children. Results: Heterozygote genotype was the most frequent in both age groups. There was no difference in the frequency distribution of genotypes between the young and the elderly. No relationship between VDR genotypes and lean mass was found in either age group. Heterozygote boys had the lowest parathormone (PTH) and heterozygote elderly women had the highest BMD at the spine and forearm. Conclusions: In the Lebanese, the relationship between VDR polymorphisms and BMD differs by age. Survival does not seem to differ by VDR genotype. However, further studies are needed to assess the effect of VDR gene polymorphisms on mortality per se and time to mortality, not evaluated in this study.

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Femoral Volumetric Bone Density, Geometry, and Strength in Relation to 25-Hydroxy Vitamin D in Older Men

Martin

Haney

Shannon

et al. 2014

Journal of Bone and Mineral Research

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Low serum 25‐hydroxy vitamin D (25(OH)D) concentrations are associated with increased hip fracture risk and decreased femoral areal bone mineral density (BMD) among elderly men. Structural dimensions of the proximal femur and volumetric BMD in cortical and trabecular compartments are also associated with hip fracture risk. However, associations of volumetric BMD or structural dimensions with serum 25(OH)D concentrations among older men remain unclear. In a random sample of 1608 men aged ≥65 years from the Osteoporotic Fractures in Men Study (MrOS), baseline serum 25(OH)D concentrations were measured by liquid chromatography/mass spectrometry assays. Femoral neck geometry and volumetric BMD derived from quantitative computed tomography included integral, cortical, and trabecular volumetric BMD; cross‐sectional area; integral and cortical volume; and cortical volume as a percent of integral volume. We studied 888 men with vitamin D, parathyroid hormone (PTH), femoral neck geometry, and BMD measures. Whole‐bone femoral strength and load‐strength ratio from finite element (FE) analysis were also available for 356 men from this sample. Multivariable linear regression was used to estimate least square means of each femoral measure within quartiles of 25(OH)D adjusted for age, race, body mass index, height, latitude, and season of blood draw. Tests of linear trend in the means were performed across increasing quartile of serum 25(OH)D levels. Mean cortical volume (p trend = 0.006) and cortical volume as a percent of integral volume (p trend < 0.001) increased across increasing quartile of 25(OH)D level. However, overall femoral neck size (area and integral volume) did not vary by 25(OH)D level. Femoral neck volumetric BMD measures increased in a graded manner with higher 25(OH)D levels (p trend < 0.001). Femoral strength, but not load‐strength ratio, increased with increasing 25(OH)D. Adjustment for PTH did not materially change these associations. We conclude that in older men, higher levels of endogenous 25(OH)D may increase whole‐bone strength by increasing femoral volumetric BMD and cortical volume. © 2014 American Society for Bone and Mineral Research.

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Hypovitaminosis D osteopathy: Is it mediated through PTH, lean mass, or is it a direct effect?

Cited by 49 publications

References 36 publications

Global vitamin D status and determinants of hypovitaminosis D

Global vitamin D status and determinants of hypovitaminosis D

Effect of age, gender and calciotropic hormones on the relationship between vitamin D receptor gene polymorphisms and bone mineral density

Femoral Volumetric Bone Density, Geometry, and Strength in Relation to 25-Hydroxy Vitamin D in Older Men

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