Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season

Alemzadeh, Ramin; Kichler, Jessica C.; Babar, Ghufran; Calhoun, Mariaelena

doi:10.1016/j.metabol.2007.08.023

Cited by 359 publications

(317 citation statements)

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“…Further, insulin resistance was negatively correlated with BMI. These findings are consistent with earlier studies of Kelly et al [29] and Alemzadeh et al [30] as they recorded a significant deficiency of vitamin D in obese children. Moreover, Alemzadeh et al [30] observed a negative correlation between vitamin D and insulin resistance.…”

Section: Discussionsupporting

confidence: 93%

“…These findings are consistent with earlier studies of Kelly et al [29] and Alemzadeh et al [30] as they recorded a significant deficiency of vitamin D in obese children. Moreover, Alemzadeh et al [30] observed a negative correlation between vitamin D and insulin resistance. Similarly, Garanty-Bogacka et al, [31] showed vitamin d deficiency in obese children compare to healthy children and a positive correlation between vitamin D and insulin resistance.…”

Section: Discussionsupporting

confidence: 93%

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Vitamin D and its Relation with Insulin Resistance in Obese Children

Mathur¹,

Soni²,

Kukreja³

2018

AIMDR

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Background: Deficiency of vitamin D leads to mal skeletal growth in children; moreover it is becoming an epidemic throughout the world. Decrease level of vitamin D can cause diverse of skeletal disorders in children like rickets, osteopenia etc. The relationship of vitamin D, obesity and insulin resistance is still not clear in the literature. Vitamin D deficiency may induce the altered glucose tolerance in obese children. Therefore the present study was designed to investigate the relationship of vitamin D and insulin resistance in obese children. Methods: The present study was a cross sectional type of study which was conducted in paediatric department of TMMC & RC, Moradabad. This study included 120 obese children (60 males and 60 females) of mean age 12 ± 2.6 years in group I. Control group II contained 100 healthy none obese children (50 males and 50 females) of 12.2 ± 1.8 years. Insulin resistance was calculated from fasting plasma measurements using HOMA-IR (insulin (mU/L) × glucose (mmol/l)/22.5). Insulin resistance criteria were HOMA-IR >2.5 for children. Vitamin D was measured by ELISA method (kit manufactured by Cayman chemical company, Ann Arbor, USA). Results: There was an insignificant difference in the FBG (>0.05) of group I obese children and group II control. Insulin (<0.05) and HOMA-IR (<0.01) were significantly low in obese children in comparison of none-obese children. Vitamin D (<0.01) was significantly lower in obese children compare to healthy children. vitamin D was negatively correlated with BMI (r = -0.42, r2 =0.1764, p<0.05) in obese children. There was a negative correlation between vitamin D and insulin resistance (r = -0.52, r2 =0.2704, p<0.05) in obese children. Conclusion: Present study suggests that there was strong relation between insulin resistance and obesity. Vitamin D was negatively correlated with BMI and insulin resistance. These findings strongly suggest vitamin D level may found insufficient or deficient in obese children. Therefore, obese children should be screened for vitamin D deficiency for their normal skeletal growth.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Vitamin D and its Relation with Insulin Resistance in Obese Children

Mathur¹,

Soni²,

Kukreja³

2018

AIMDR

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“…A number of studies have reported a negative association between serum 25(OH)D concentration and body fat (Alemzadeh et al, 2008;McKinney et al, 2008;Kremer et al, 2009), perhaps due to the sequestration of the vitamin by the fat (Liel et al, 1988). Several studies performed on adults have reported a negative relationship between BMI and serum levels of vitamin D (Need et al, 2005;Konradsen et al, 2008;Kremer et al, 2009;Rodríguez-Rodríguez et al, 2009), and the same has been reported for children and adolescents (Alemzadeh et al, 2008;Bener et al, 2008a, b). In a group of 127 children and adolescents, Alemzadeh et al (2008) observed that those with serum 25(OH)D concentrations of o75 nmol/l had a greater BMI than those with higher concentrations (38.2±8.9 vs 33.9±6.0 kg/m 2 ; Po0.02).…”

Section: Discussionmentioning

confidence: 99%

“…Epstein et al (1986) and Nesby-O'Dell et al (2002) reported no relationship between body mass index (BMI) or obesity and serum 25-hydroxyvitamin D (25(OH)D) levels, whereas Parikh et al (2004) found a negative significant correlation between BMI and serum 25(OH)D in African Americans. In addition, few studies have been undertaken in children (Alemzadeh et al, 2008;Rajakumar et al, 2008) and none has studied the relationship between the distribution of body fat and vitamin D status in children (Alemzadeh et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren

et al. 2010

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Background/Objectives: To analyze the association between different anthropometric variables and vitamin D status in a group of Spanish schoolchildren. Subjects/Methods: Study subjects were 102 children aged 9-13 years. Records were made of their height, body weight, body mass index (BMI), waist and hip measurements (to determine the quantity of visceral or abdominal fat), and the thickness of the tricipital and bicipital skinfold (to determine the quantity of subcutaneous fat). Diets were analyzed using a 3-day weighed food record and vitamin D intakes compared with those recommended. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured using chemiluminescent assay. Results: The mean serum 25(OH)D concentration was 49.6 ± 15.9 nmol/l. The mean serum 25(OH)D in the ID subjects (that is, those with insufficient vitamin D levels, 25(OH)D of o70 nmol/l) was 46.6 ± 13.4 nmol/l and in the AD subjects (that is, those with adequate vitamin D levels, 25(OH)D of X70 nmol/l) was 77.5 ± 8.4 nmol/l (Po0.001). No significant difference was observed between both groups in vitamin D intake. However, the ID subjects had higher body weight, BMI, waist measurement and waist/height ratio than the AD subjects. Using a multiple linear regression analysis, only weight and BMI were found to independently influence 25(OH)D values. Children with a body weight, BMI, bicipital skinfold thickness, waist measurement and waist/height ratio above the 50th percentile for each variable were at a greater risk of having a low serum 25(OH)D concentration (o70 nmol/l). Conclusions: BMI and abdominal obesity influence the appearance of vitamin D insufficiency in children.

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“…Furthermore, we looked at this association across the whole spectrum of adiposity. Previous studies have generally either looked at this association among the obese only (11,13,31) , while studies that have expanded their investigation beyond the high end of the spectrum have included underweight individuals within the BMI , 25?0 kg/m 2 category or assumed that the relationship is linear (3)(4)(5)(6)30,38) . The present study has specifically looked at vitamin D status at the lower end of the BMI/BF% spectrum and has provided evidence that people within the lower end of adiposity might also have compromised vitamin D levels.…”

Section: Limitationsmentioning

confidence: 99%