Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women

Maghraoui, A. El; Ouzzif, Z.; Mounach, Aziza; Rezqi, Asmaa; Achemlal, L.; Bezza, A.; Tellal, Saida; Dehhaoui, Mohamed; Ghozlani, I.

doi:10.1186/1472-6874-12-11

Cited by 51 publications

(39 citation statements)

References 41 publications

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“…22 Additionally, investigations in Saudi Arabia, Kuwait, the United Arab Emirates and Iran indicate that 10---60% of mothers and 40---80% of their neonates have undetectable or low 25-OH vitamin D levels (0---25 nmol/L) at the time of delivery. 15 Published studies from North Africa are rather scarce; two studies were reported from Morocco (one study included 178 elderly females in the spring, the other included 415 females aged 24---77) 23,24 and two from Tunisia (one study included 261 females and 128 males, the other included 134 females) 25,26 ; two of the four studies were conducted in spring and winter and the other two in summer. The relation to various variables as sun exposure, veiling and dietary intake was reported in only two studies.…”

Section: Discussionmentioning

confidence: 97%

Vitamin D deficiency among healthy Egyptian females

Botros

Sabry

Abdelbaky

et al. 2015

Endocrinología y Nutrición

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Section: Discussionmentioning

confidence: 97%

Vitamin D deficiency among healthy Egyptian females

Botros

Sabry

Abdelbaky

et al. 2015

Endocrinología y Nutrición

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“…44 However, recently, hypovitaminosis D has been also associated to an increased risk of vertebral fractures. 45 Even though the definition of normal 25(OH)D plasma concentration is still debated, a classification of vitamin D status on which many would agree is: deficiency 25(OH)D <20 ng/mL (<50 nmoL/L), insufficiency 20-30 ng/mL (50-75 nmoL/L), normality >30 ng/mL (>75 nmoL/L). 46 Vitamin D supplementation seems to be linked to favorable clinical outcomes.…”

Section: Vitamin D/pth System and Bone Healthmentioning

confidence: 99%

Osteoporosis in rheumatoid arthritis: role of the vitamin D/parathyroid hormone system

Bellan

Pirisi

Sainaghi

2015

Revista Brasileira de Reumatologia (English Edition)

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RBRE-172; No. of Pages 8 r e v b r a s r e u m a t o l . 2 0 1 4;x x x(x x):xxx-xxx REVISTA BRASILEIRA DE REUMATOLOGIA w w w . r e u m a t o l o g i a . c o m . b r Available online xxx Keywords: Cholecalciferol PTH Osteoporosis Rheumatoid arthritis a b s t r a c t Osteoporosis is a well-established extra-articular feature of rheumatoid arthritis (RA). Systemic inflammation seems to play a crucial role in causing an alteration of multiple homeostatic systems implied in bone health, such as the RANK/RANKL/Osteoprotegerin and Wnt/␤ catenin pathways; several other causal factors have been called into question, including the chronic use of corticosteroids. Since vitamin D exerts important immune-regulatory roles, it has been claimed that derangement of the vitamin D/parathyroid hormone (PTH)system, a well-known determinant of bone health, may play a pathogenic role in autoimmunity; animal models and clinical data support this hypothesis. Furthermore, RA patients seem to be relatively refractory to vitamin D-induced PTH suppression. Therefore, the link between RA and osteoporosis might in part be due to alterations in the vitamin D/PTH system. A better understanding of the pathophysiology of this system may be crucial to prevent and cure osteoporosis in patients with inflammatory/autoimmune diseases. A major clinical correlate of the strict cooperation and interdependence between vitamin D and PTH is that correction of the vitamin D deficiency, at least in autoimmune diseases, should be targeted to PTH suppression. Osteoporose na artrite reumatoide: papel do sistema vitamina D/HPTPalavras chave: Colecalciferol HPT Osteoporose Artrite reumatoide r e s u m o A osteoporose é uma característica extra-articular bem estabelecida da artrite reumatoide (AR). A inflamação sistêmica parece ser essencial para causar uma alteração em múltiplos sistemas homeostáticos implicados na saúde óssea, como as vias RANK/RANKL/osteoprotegerina e Wnt/␤ catenina; vários outros fatores causais têm sido implicados, como o uso crônico de corticosteroides. Como a vitamina D exerce funç ões RBRE-172; No. of Pages 8 2 r e v b r a s r e u m a t o l . 2 0 1 4;x x x(x x):xxx-xxx imunorreguladoras importantes, tem-se afirmado que o desarranjo do sistema vitamina D/hormônio paratireóideo (HPT), um determinante bem conhecido da saúde óssea, pode desempenhar um papel patogênico na autoimunidade; estudos com animais e dados clíni-cos apoiam essa hipótese. Além disso, os pacientes com AR parecem ser relativamente refratários à supressão de HPT induzida pela vitamina D. Portanto, a ligação entre a AR e a osteoporose pode ser em parte causada por alteraç ões no sistema vitamina D/HPT. Uma melhor compreensão da fisiopatologia desse sistema pode ser crucial para prevenir e curar a osteoporose em pacientes com doenças inflamatórias/autoimunes. A maior evidência da correlação clínica de cooperação e interdependência entre a vitamina D e o HPT é que a correção da deficiência de vitamina D, pelo menos nas doenças autoimunes, deve ser orientada para a supressão do H...

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“…The positive correlation between the BAP and PTH allows to suggest that the increase of BAP is associated to hyperparathyroidism leading the hyperactivity of bone and predict the risk of osteomalacia and secondary osteoporosis among women (12,18).…”

Section: Discussionmentioning

confidence: 98%

Association between the bone turnover markers and the gynecologic factors among Moroccan women

Nejjar

Bour

Sfendla³

et al. 2017

AABS

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Background:The action of bone cells on the bone mineral density can be highlighted from their enzymatic activities, by the bone alkaline phosphates (BAP) and the Cross Laps-telopeptide terminal of the collagen type 1 (β-CTX). They are reliable to explore the activity of bone turnover. We aim to put in perspective the association between gynecological factors and the concentration of bone turnover markers (BTMs) among Moroccan women.Methods: This is a cross-sectional study of 125 women from February to April 2015. A randomized sample was made. The biochemical parameters of bone metabolism concerned serum calcium, 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH), phosphorus , BAP and β-CTX. All data related to gynecologic, sociodemographic and anamnesis parameters was collected by standardized questionnaire.Result: Among 125 women, 64(51.42) were menopausal, the mean BAP was 22.1±7.6 ng/L, the median of the interval between successive births "IBSB" and of β-CTX were 36.0 [24.0-58.0] months, 368.5 [237.0-504.8]ng/L. A positive correlation was observed between the β-CTX and IBSB (r=0.2,p=0.05). The BAP concentration was higher in menopausal women (p<0.001). The linear regression showed that 12% of BAP concentration was associated to the menopause (R 2 =0.12, p=0.001) but no associated factors was founded with concentration of β-CTX. Conclusion:Our study shows that the menopause is associated factor with concentration of BAP and IBSB is correlated with the concentration of β-CTX. Keywords IntroductionThe bone remodeling is a complex physiological process during which the osteoclasts, cells of bone resorption, and the osteoblasts, cells of bone formation, act in sequential and coupled frequencies to destruct and renew the bone matrix. The objective of this physiological process is to lead an adequate bone mineral density (BMD) depending on the age and the sex (1). This bone remodeling process is under the action of several factors such as biological mediators, cited the vitamin D and the calcium, also under the action of sexual hormones and under the action of some external parameters related to the lifestyle of the person (1, 2).The action of these cells on the bone can be highlighted from their enzymatic activities by the biochemical markers of bone turnover: Bone Alkaline Phosphatase (BAP) and C-telopeptide Terminal Collagen type 1 (β-CTX). The BAP is an enzyme of the bone formation specific to the osteoblasts whereas the β-CTX is an enzyme of bone resorption specific to the osteoclasts (2). The use of these enzymes are reliable to their non invasive exploration of bone turnover (3), they allow in association with the bone densitometry to estimate the loss of bone and to monitor the response of therapeutic effect of several bone diseases (4).The trend to establish a link between markers and BMD was also subject to research among Moroccan researchers (5,6). Yet, to our knowledge, no study so far in Morocco has been undertaken to study the associated factors with the concentration of biochemical of bo...

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Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women

Cited by 51 publications

References 41 publications

Vitamin D deficiency among healthy Egyptian females

Vitamin D deficiency among healthy Egyptian females

Osteoporosis in rheumatoid arthritis: role of the vitamin D/parathyroid hormone system

Association between the bone turnover markers and the gynecologic factors among Moroccan women

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