Hypovirulence of Mycoviruses as a Tool for Biotechnological Control of Phytopathogenic Fungi

Kyrychenko, A. M.; Tsyganenko, K. S.; Olishevska, Snizhana

doi:10.3103/s0095452718050043

Cited by 5 publications

(4 citation statements)

References 95 publications

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“…Biological control is an effective method for combatting this disease [ 30 , 31 ]. In recent years, a large number of hypovirulent mycoviruses, such as CHV1 [ 13 ] and SsHADV1 [ 49 ], have been identified and explored as potential biocontrol agents against fungal diseases [ 4 , 32 , 33 ]. However, until now, only two mycoviruses, FodV1 and FoOuLV1, isolated from F. oxysporum , exerted hypovirulent effects [ 34 , 35 , 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Biocontrol agents, such as plant growth- promoting rhizobacteria (PGPR) strains and nonpathogenic F. oxysporum strains, have proven to be effective tools for controlling plant diseases caused by F. oxysporum [ 30 , 31 ]. As more hypovirulence-associated mycoviruses have been investigated in attempts to control crop diseases, new insights and explorations regarding biological control using hypovirulence-associated mycoviruses to control plant diseases caused by F. oxysporum [ 4 , 32 , 33 ] have become available. To our knowledge, six mycoviruses have been reported in F. oxysporum .…”

Section: Introductionmentioning

confidence: 99%

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Molecular Characterization of the First Alternavirus Identified in Fusarium oxysporum

Wen

Wan

Zhang

et al. 2021

Viruses

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A novel mycovirus named Fusarium oxysporum alternavirus 1(FoAV1) was identified as infecting Fusarium oxysporum strain BH19, which was isolated from a fusarium wilt diseased stem of Lilium brownii. The genome of FoAV1 contains four double-stranded RNA (dsRNA) segments (dsRNA1, dsRNA 2, dsRNA 3 and dsRNA 4, with lengths of 3.3, 2.6, 2.3 and 1.8 kbp, respectively). Additionally, dsRNA1 encodes RNA-dependent RNA polymerase (RdRp), and dsRNA2- dsRNA3- and dsRNA4-encoded hypothetical proteins (ORF2, ORF3 and ORF4), respectively. A homology BLAST search, along with multiple alignments based on RdRp, ORF2 and ORF3 sequences, identified FoAV1 as a novel member of the proposed family “Alternaviridae”. Evolutionary relation analyses indicated that FoAV1 may be related to alternaviruses, thus dividing the family “Alternaviridae” members into four clades. In addition, we determined that dsRNA4 was dispensable for replication and may be a satellite-like RNA of FoAV1—and could perhaps play a role in the evolution of alternaviruses. Our results provided evidence for potential genera establishment within the proposed family “Alternaviridae”. Additionally, FoAV1 exhibited biological control of Fusarium wilt. Our results also laid the foundations for the further study of mycoviruses within the family “Alternaviridae”, and provide a potential agent for the biocontrol of diseases caused by F. oxysporum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of the First Alternavirus Identified in Fusarium oxysporum

Wen

Wan

Zhang

et al. 2021

Viruses

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“…Next, the interest in these pathogens is also stimulated by technical advances in the field of mycovirus molecular biology. Finally, mycoviruses have been successfully used as tools to study host interactions and control mechanisms (Kyrychenko et al, 2018).…”

Section: Mycovirusesmentioning

confidence: 99%

Mycoviruses infecting Colletotrichum spp.: A comprehensive review

et al. 2023

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Colletotrichum is one of the most economically important fungal genera, which affects a wide range of hosts, specifically tropical and subtropical crops. Thus far, there have been several records of mycovirus infection in Colletotrichum spp., primarily by viruses of the Partitiviridae family. There have also been records of infections by mycoviruses of the Chrysoviridae family. Mycoviruses are (+)ssRNA and dsRNA genome viruses, which may or may not be enveloped. To date, no mycovirus with a DNA genome has been isolated from Colletotrichum spp. Typically, mycoviruses cause latent infections, although hypo- and hypervirulence have also been reported in Colletotrichum spp. In addition to its effects on pathogenic behavior, mycovirus infection can lead to important physiological changes, such as altered morphological characteristics, reduced vegetative growth, and suppressed conidia production. Therefore, research on mycoviruses infecting phytopathogenic fungi can help develop alternative methods to chemical control, which can cause irreversible damage to humans and the environment. From an agricultural perspective, mycoviruses can contribute to sustainable agriculture as biological control agents via changes in fungal physiology, ultimately resulting in the total loss of or reduction in the virulence of these pathogens.

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“…As mentioned above, the effect of hypovirulence was first described in Chestnut blight pathogen C. parasitica strains isolated from poorly pigmented (in contrast to the bright-orange necrotic segments) strains in Europe (Kyrychenko et al, 2018). Cryphonectria hypoviruses 1 -4 (CHV1 -4) are grouped in genus Hypovirus in family Hypoviridae (Nuss and Hillman, 2011).…”

Section: Hypovirulence As a Tool For Biologi-cal Controlmentioning

confidence: 99%

Biological control of pathogenic fungi: Can mycoviruses play an important role?

Tonka¹,

Walterová²,

Čurn³

2022

j. cent. eur. agric.

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In the past few years, huge economic and environmental losses have resulted by fungal pathogens in agriculture and food production worldwide. Fungal toxins also pose a threat for food production and animal health. In the last decade, the site-specific fungicides has been used in plant protection, providing highly efficient protection against phytopathogens. However, the use of pesticides boosted problems with resistance in the targeted organisms and increased negative environmental impact of insecticides, herbicides and fungicides. Therefore, new methods are needed to control resistant populations of plant pathogens, including fungi. Mycoviruses are fungal viruses, i.e. viruses infecting fungi. Some mycoviruses affect the growth and virulence of the host fungus and may prevent successful infection of plant host. They have potential to reduce phytopathogens. In this review, the successful examples how mycoviruses alter hypovirulence in well-known phytopathogens are discussed. Mycoviruses could be useful as a one of new next generation pest-control products.

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Hypovirulence of Mycoviruses as a Tool for Biotechnological Control of Phytopathogenic Fungi

Cited by 5 publications

References 95 publications

Molecular Characterization of the First Alternavirus Identified in Fusarium oxysporum

Molecular Characterization of the First Alternavirus Identified in Fusarium oxysporum

Mycoviruses infecting Colletotrichum spp.: A comprehensive review

Biological control of pathogenic fungi: Can mycoviruses play an important role?

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