Hypothyroidism Results in Small Dense LDL Independent of IRS Traits and Hypertriglyceridemia

Abbas, Jasem M. K.; Chakraborty, J.; Akanji, Abayomi O.; Doi, Suhail A.R.

doi:10.1507/endocrj.k07e-065

Cited by 37 publications

(45 citation statements)

References 40 publications

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“…Results of Abbas et al's study supported an independent association between LDL particle size phenotype, plasma TG and thyroid status [26]. In another study that investigated overt hypothyroid patients, no significant discordance in percentages of B phenotype (predominance of sdLDL-C) compared to the controls was found [30].…”

Section: Discussionmentioning

confidence: 76%

“…Some studies investigated connection between SHypo and dyslipidemia with heterogeneous results. In a crosssectional study of 1149 women aged ≥ 55 years and in large studies subjects with subclinical hypothyroidism had a significantly higher prevalence of CHD than in euthyroid subjects [14,26]. The initial analysis of the Whickham Survey found no association between autoimmune thyroid disease and SHypo over 20 years of follow-up, but re-analysis of the data, looking specifically at individuals with SHypo found an increase in CHD events and mortality [27].…”

Section: Discussionmentioning

confidence: 99%

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Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C)

Šarić

Jurašić²,

Sović

et al. 2017

Romanian Journal of Internal Medicine

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Background. Usually both hypothyroidism and hyperthyroidism are related to the cardiovascular and cerebrovascular disease development. The relationship between subclinical hypothyroidism has been widely investigated but the findings remain controversial. The aim of the present study was to evaluate the lipid profile in patients with subclinical hypothyroidism (SHypo) in comparison to controls and to determine the association of SHypo and dyslipidemia in attempt to find importance of small dense low-density lipoprotein cholesterol (sdLDL-C) in atherosclerosis.Material and methods. In this study we included 100 women, aged 30 to 70 years that were divided into subgroups according to their age. According to the values of levels of thyroid hormones they were divided into euthyroid (control) group (n = 64) and (newly discovered) subclinical hypothyroidism (SHypo) group (n = 36). A high-sensitivity C-reactive protein (hs-CRP) and lipid profile, including small dense low-density lipoprotein cholesterol (sdLDL-C) were determined. Body weight and height were measured and BMI calculated. History of the current illness, medication, alcohol consumption and cigarettes smoking were noted.Results. Changed lipid profile as well as elevated triglycerides and sdLDL-C were observed in the group with subclinical hypothyroidism compared to the control group.Conclusions. It is important to determine serum lipid levels, especially serum sdLDL-C levels at an early stage of subclinical hypothyroidism, since they represent atherogenic LDL particles and are better indicators for dyslipidaemia in subclinical hypothyroidism and the development of atherosclerosis with potential complications such as cardiovascular and cerebrovascular diseases.

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C)

Šarić

Jurašić²,

Sović

et al. 2017

Romanian Journal of Internal Medicine

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“…A period of 4-6 weeks of thyroxin replacement therapy is usually needed to correct dyslipidemia in overt hypothyroidism. A study in newly-diagnosed hypothyroid patients showed a decrease in serum TC and LDL levels after thyroxine treatment [8]. But no clear consensus has been established regarding the treatment of SH subjects [9,10].…”

Section: Introductionmentioning

confidence: 99%

Study of serum lipid profile in subclinical hypothyroidism

Patel¹,

Patel²,

Makadia³

et al. 2016

Int J of Biomed & Adv Res

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Objective: It has been known that overt hypothyroidism is associated with hyperlipidemia, replacement therapy with Levothyroxine significantly reverses lipid metabolism abnormalities. But no clear consensus has been established regarding the treatment of Subclinical Hypothyroidism subjects. This is due to the fact that there are no data from large trials on whether and to what degree Subclinical Hypothyroidism affects lipid profile. This study is aimed to provide a look at the status of Lipid Profile in the case of Subclinical Hypothyroidism. Materials and Methods: Total 100 subjects were recruited and divided into 2 groups. 50 Patients with Subclinical Hypothyroidism were considered as the cases and 50 healthy people as the controls. Serum TSH was analysed by sandwich electrochemiluminescence immunoassay method. Serum cholesterol, triglyceride and HDL were estimated by enzymatic colorimetric method, LDL was calculated by using friedewald formula. Results: Serum cholesterol, LDL were higher (P<0.0001) and HDL (P<0.0001) was lower in Subclinical Hypothyroid patients (mean±SD= 199.9±27.8 mg/dl, 130.0±26.3mg/dl, 44.2±9.1 mg/dl respectively) compared to healthy controls (mean±SD= 170.1±16.8 mg/dl, 97.3±14.7 mg/dl, 54.2±10.0 mg/dl respectively). A significant correlation was found between the levels of TSH and Serum Cholesterol (r=0.5101, P<0.0001), LDL (r=0.5637, P<0.0001) and a significant negative correlation was found between the levels of TSH and HDL (r=-0.4525, P<0.0001). Conclusion: Subclinical hypothyroidism is associated with elevated levels of Serum Total Cholesterol and LDL which is atherogenic in nature, and low level of HDL. This may further increase the risk of development of atherosclerosis.

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“…5 Though a recent study conducted on newly diagnosed hypothyroid patients showed an association between hypothyroidism and elevated LDL, other studies could not conclusively prove such an association. 29,30,31 All these results reiterate the need for studies on the association of fasting Lipid levels with SCH. In our study, we have attempted to bridge this gap and from our results, it could be speculated that though serum LDL-C was higher in SCH subjects and useful cholesterol HDL was comparatively low.…”

Section: Discussionmentioning

confidence: 75%

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

Zubair

Ijaz²,

Aftab³

2017

Annals KEMU

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A controversy exists regarding the association between subclinical hypothyroidism (SCH) and dyslipidemia. Moreover, studies on lipid ratios in SCH are rare, particularly in Asian Countries. The study also aims to find out whether any correlation exists between serum TSH levels and fasting lipid levels, which would indirectly affect morbidity and mortality. Methods:The study was conducted at Physiology department, KEMU and Centre for Nuclear Studies KEMU & Mayo Hospital, Lahore which is a tertiarycare center. It was a cross-sectional study carried out over a period of 6 months. Control group consisted of 50 euthyroid persons taken from a population coming for whole-body health checkup. Case group consisted of 50 patients with SCH. Confounding variables were removed. Fasting blood samples were taken in a plain gel vaccutainer tube with an aseptic blood collection technique. The samples were centrifuged within 1 h at 3000 rpm for 5 min. These were 1 Assistant Professor of Physiology

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Hypothyroidism Results in Small Dense LDL Independent of IRS Traits and Hypertriglyceridemia

Cited by 37 publications

References 40 publications

Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C)

Dyslipidemia in subclinical hypothyroidism requires assessment of small dense low density lipoprotein cholesterol (sdLDL-C)

Study of serum lipid profile in subclinical hypothyroidism

Correlation between Thyrotropin and Fasting Lipid Profile in Patients of Sub Clinical Hypothyroidism

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