Hypothyroidism following Treatment for Head and Neck Cancer

Vrabec, Donald P.; Heffron, Timothy J.

doi:10.1177/000348948109000506

Cited by 47 publications

(48 citation statements)

References 15 publications

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“…The only way to achieve an early diagnosis is by initial suspicion and periodic evaluation of the thyroid function, particularly in the group of patients at greater risk. Once the hypothyroidism, clinical or subclinical, is detected, all authors agree on the necessity for substitutive treatment [5,8,10,16]. Treatment with levothyroxine is effective, safe, well-tolerated and cost-effective.…”

Section: Discussionmentioning

confidence: 97%

“…In some studies with head and neck carcinoma patients, hypothyroidism appeared more frequently in women [4,8,16], possibly in relation to the increased prevalence of thyroid disorders in females. Other authors did not find any relation between sex and hypothyroidism in head and neck cancer patients [5,13].…”

Section: Discussionmentioning

confidence: 99%

“…The combined treatment of surgery and radiotherapy [4,5,8,10,12,16], the inclusion of all the thyroid gland in the field of radiotherapy treatment [5,13], the radiotherapy doses [17] and the performance of hemithyroidectomy [2,3,4,5,10,12,14,16,17] have been variables related to the appearance of hypothyroidism in head and neck cancer patients.…”

Section: Discussionmentioning

confidence: 99%

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Hypothyroidism in patients treated with total laryngectomy. A multivariate study

Lóon

Gras

Pérez

et al. 2002

European Archives of Oto-Rhino-Laryngology

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One of the complications of the treatment of head and neck carcinoma patients is hypothyroidism. The objective of our study was to quantify the prevalence of hypothyroidism in patients with laryngeal or hypopharyngeal cancer treated with a total laryngectomy and to evaluate the importance of different variables in the appearance of hypothyroidism in this group of patients. A transversal study in 182 patients treated with total laryngectomy between 1986 and 1998 was carried out. TSH and FT4 were determined in all patients. Hypothyroidism was classified as subclinical (increased TSH and normal T4 levels) and clinical (increased TSH and decreased T4 levels). Univariate and multivariate analysis was carried out to examine the relationship between hypothyroidism and different variables. Our results showed that the prevalence of hypothyroidism in our group of patients was 52% (27% subclinical and 25% clinical). Sex, initial extension of the tumour, hemithyroidectomy, use of chemotherapy and radiotherapy were variables associated with the appearance of hypothyroidism in the univariate analysis (P < 0.05). When all these variables were included in a multivariate study, only hemithyroidectomy (RR 3,6; CI 95% 1,7-7,2) and combined treatment with radiotherapy (RR 3,4; CI 95% 1,2-9,6) appeared as prognostic factors. In conclusion, hypothyroidism is a frequent complication in patients treated with a total laryngectomy (52%), especially when this treatment includes hemithyroidectomy and/or radiotherapy. We consider that it is important to check the thyroid function periodically in these patients to obtain early diagnosis and appropriate treatment.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hypothyroidism in patients treated with total laryngectomy. A multivariate study

Lóon

Gras

Pérez

et al. 2002

European Archives of Oto-Rhino-Laryngology

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“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16] Not surprisingly, patients who undergo partial thyroidectomy as part of their treatment have a greater likelihood of developing hypothyroidism. Such patients were excluded from our series.…”

Section: Discussionmentioning

confidence: 99%

Hypothyroidism

Mercado

Adelstein

Saxton

et al. 2001

Cancer

146

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The use of an internal circulating fluidized bed (ICFB) is proposed for the oxidative dehydrogenation of butane. The reactor consists of two adjacent zones, separated by a wall. In the oxidizing zone the catalyst is oxidized and in the reducing zone the butane is dehydrogenated by reaction with the oxygen from the catalyst lattice. The circulation between both zones is produced by the different bed porosity, which originates a pressure difference between the two zones at the communication orifice at the bottom of the vessel. The design of this reactor is studied in a cold model. An image analysis technique was applied to measure solid circulation rates between the different regions in the reactor, by using a solid coated with a long afterglow phosphor as a tracer. The solid circulation rates through the orifices were found to correlate reasonably well with a previously developed correlation for the orifice drag coefficient. The model for solid circulation between fluidized regions was then integrated in the overall mathematical model for the ICFB reactor system to incorporate the effect of design and operating conditions on the catalyst circulation rates between compartments. A good correlation between the experimentally obtained values of conversion and selectivity and those predicted by the model is obtained. Improvements in selectivity to olefins are obtained, compared with conventional fluidized‐bed reactors with cofeeding of reactants. © 2004 American Institute of Chemical Engineers AIChE J, 50: 1510–1522, 2004

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“…Radiation-induced primary hypothyroidism has been reported to occur rather frequently after mantle irradiation in Hodgkin's disease (10) and following treatment of head and neck cancer (12). In view of these reports and of the occasional observation of breast cancer patients with primary hypothyroidism at this hospital, an investigation was carried out on the effect on thyroid function of postoperative radiation therapy following mastectomy, and the results are now presented.…”

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confidence: 97%