Hypothyroidism-associated rhabdomyolysis

Opium-Induced Rhabdomyolysis and Acute Renal Failure in a Patient Taking Opium Habitually: a Case Report

“…Rhabdomyolysis results from inherited muscle enzyme deficiencies, toxins such as alcohol and opiates, trauma, medication such as fibrates and statins, muscle overexertion, infections, hypothyroidism and other disorders (3)(4)(5). Alcohol abuse, trauma, the use of fibrates, statins, antipsychotics, selective serotonin reuptake inhibitors, or lithium, infection and hypothyroidism were excluded in our patient.…”

“…Myoglobinuria is the most significant consequence, leading to acute renal failure (ARF) in 15%-33% of patients with rhabdomyolysis. Rhabdomyolysis results from inherited muscle enzyme deficiencies, toxins such as alcohol, opiates and cocaine, trauma, medications such as fibrates and statins, muscle overexertion, infections, hypothyroidism and other disorders (3)(4)(5). Rhabdomyolysis has been reported in 22 of 188 consecutive patients with acute opiate intoxication (6).…”

Adolescent with Rhabdomyolysis due to Undiagnosed Hypothyroidism

“…Myopathy is a common presentation of hypothyroidism and may be accompanied by asymptomatic or mild to moderate CK elevation, usually less than ten times the upper limit of normal [6]. To our knowledge, there have been eight case reports of hypothyroid-induced rhabdomyolysis in the English literature [3–10]; three have been reported in children or young adults [5, 7, 10]. Although the CK level does not correlate with the severity of the myopathic process [8], the CK elevation in our patient was profound.…”

“…Although the CK level does not correlate with the severity of the myopathic process [8], the CK elevation in our patient was profound. Literature review indicates that this patient's CK value is the highest documented value in a patient with hypothyroid-induced rhabdomyolysis [3–10]. …”

“…Trauma, exertion, muscle hypoxia, genetic defects, infections, body-temperature changes, metabolic and electrolyte disorders, drugs, and toxins are causes of rhabdomyolysis [1]. Hypothyroid patients may present with myopathy and mild elevation of CK levels; however, overt rhabdomyolysis is extremely rare, and few cases have been described [3–10]. …”