Hypothyroidism, an important cause of reversible hyperlipidemia

Mishkel, Maurice A.; Crowther, S. M.

doi:10.1016/0009-8981(77)90215-7

Cited by 34 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…y TSH were suppressed to subnormal levels. Wahlqvist et al, 1977;Aviram et al, 1982;O'Kane et al, 1991;Mishkel & Crowther, 1977;Angelin et al, 1983). In these patients the initial TSH values were on average 12 times (range 6-29) the upper level of the normal range.…”

Section: The Association Between Tsh and Total Cholesterol In Patientmentioning

confidence: 75%

Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies

Tanis

Westendorp

Smelt

1996

Clinical Endocrinology

172

View full text Add to dashboard Cite

show abstract

Section: The Association Between Tsh and Total Cholesterol In Patientmentioning

confidence: 75%

Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies

Tanis

Westendorp

Smelt

1996

Clinical Endocrinology

172

View full text Add to dashboard Cite

show abstract

“…Reports indicate that TSH level and hyperlipidaemia in hypothyroidism normalise slowly with thyroxine replacement therapy [44,45], and even atherogenic lipid profile persists after attainment of euthyroid state, especially in males [46]. As hypothyroidism is a chronic disease and requires prolonged therapy for full recovery, the patients, especially males, are susceptible to oxidative damage.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference

2008

View full text Add to dashboard Cite

Oxidative stress (OS) has recently been documented in hypothyroidism, a disease more prevalent in women. In general, OS is reported to be more prevalent in males. However, the effect of gender on OS and protein glycation in hypothyroidism has not been addressed. Blood samples from 37 recently diagnosed primary hypothyroid patients were collected before initiation of thyroxine therapy. Serum glucose, thyroid and lipid profiles were estimated. Glutathione (GSH), malondialdehyde (MDA), protein carbonylation (PCO) and fructosamine levels were analysed. GSH was found to be lower, whereas MDA, fructosamine and PCO levels were higher in male than in female patients. Level of MDA was significantly correlated with fructosamine, protein carbonyls, cholesterol, low-density and high-density lipoprotein cholesterol, triglyceride and GSH in hypothyroid patients. We found OS to be more prevalent in male hypothyroid patients. The positive association of MDA with fructosamine indicates that enhanced lipid peroxidation could be a plausible contributor for accelerated glycation of protein. Considering the negative influence of OS on health, extra attention should be paid to male hypothyroid patients in spite of the low prevalence of this disease in them.

show abstract

“…A majority of investigators observed that the plasma concentration of TG was elevated in the hypothyroid state, particularly in myxedema (9,15,(96)(97)(98) although the concentration may be normal (18,19,28,93,99). The plasma TG concentration clearly is the net result of several metabolic processes, including absorption of dietary fat (chylomicrons), endogenous synthesis of the VLDL by the liver and secretion into plasma, and clearance of chylomicrons and VLDL from the plasma.…”

Section: Synthesis and Secretion Of Tg And The Vldlmentioning

confidence: 99%

Plasma Lipoproteins and Regulation of Hepatic Metabolism of Fatty Acids in Altered Thyroid States*

1985

View full text Add to dashboard Cite

This article reviews our understanding of effects of thyroid hormone excess and deficiency on hepatic metabolism of FFA, and consequent effects on production, secretion, and metabolism of plasma lipoproteins. In the hyperthyroid state the following alterations are observed. Fatty acid oxidation and ketogenesis are stimulated simultaneously with a paradoxical stimulation of fatty acid synthesis, which may be linked by virtue of a blunted response of mitochondrial carnitine palmitoyltransferase I (CPT-I) to malonyl coenzyme A (CoA). Esterification of fatty acid to triglyceride (TG) is reduced, as is the secretion of the very low density lipoprotein (VLDL) (including VLDL TG, cholesterol, and apoprotein); this may be due, in part, to decreased concentrations of glycerol-3-phosphate (G3P) in the hepatic cell. In the intact animal or patient, however, serum TG concentration is variable, which may reflect increased adipose tissue lipolysis and elevated concentrations of plasma FFA, which would tend to drive VLDL secretion by the liver. Clearance of the VLDL and its metabolic product, the low density lipoprotein (LDL), is increased, resulting in decreased plasma total and LDL cholesterol. Although high density lipoprotein (HDL) cholesterol may also be reduced, the ratio of LDL/HDL cholesterol is further decreased. The regulatory role of the lipoprotein apoproteins is less clear, but hepatic apolipoprotein (apo) B secretion (required for VLDL) is diminished, while apo-AI secretion (required for HDL) is stimulated, perhaps both reflecting rates of synthesis. Plasma concentrations of apo-AI are variable, dependent on relative rates of secretion and clearance. In the hypothyroid, many of these effects are reversed, which results in hyperlipoproteinemias and greater risk for the development of atherosclerotic cardiovascular disease.

show abstract

Hypothyroidism, an important cause of reversible hyperlipidemia

Cited by 34 publications

References 7 publications

Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies

Effect of thyroid substitution on hypercholesterolaemia in patients with subclinical hypothyroidism: a reanalysis of intervention studies

Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference

Plasma Lipoproteins and Regulation of Hepatic Metabolism of Fatty Acids in Altered Thyroid States*

Contact Info

Product

Resources

About