Hypothyroidism: age-related influence on cardiovascular nitric oxide system in rats

Sarati, Lorena Ivonne; Martínez, Carla; Artés, Nicolás; Arreche, Noelia; López‐Costa, Juan José; Balaszczuk, Ana M.; Fellet, Andrea L.

doi:10.1016/j.metabol.2012.01.022

Cited by 21 publications

(31 citation statements)

References 32 publications

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“…Hypothyroidism would exhibit a greater eccentric hypertrophic response, while hyperthyroid animals would exhibit concentric hypertrophic response. These findings agreed with other authors who described the development of the eccentric hypertrophy in hypothyroidism (Wang et al 2010, Sarati et al 2012 and concentric left ventricle hypertrophy associated with thyrotoxicosis (Abergel et al 1995). The mechanisms of the animal model of thyroid disturbances-induced cardiac hypertrophy are multifactorial.…”

Section: Discussionsupporting

confidence: 92%

“…Additionally, we demonstrated that hypothyroidism contributes in a differential way to ageing-induced changes in the myocardium and aorta tissues. Low thyroid hormones levels would enhance the ageing effect on the heart related to cardiac NO production (Sarati et al 2012). We also revealed that the heart of male and female rats undergoes distinct adaptive responses to hyperthyroidism that confer to the latter, a relatively stronger adaptation profile that appears to be related to the ability to regulate NO production (Rodríguez et al 2015).…”

Section: Introductionmentioning

confidence: 73%

“…Reaction mixtures were loaded onto cation exchange columns (Dowex AG 50W-X8, Na + form; Bio-Rad) and [ 14 C (U)]-l-citrulline was eluted from columns with 0-50 mL ddH 2 O. The amount of [ 14 C (U)]-l-citrulline eluted was quantified using a liquid scintillation counter (Wallac 1414 WinSpectral; EG&G Company, Turku, Finland) as described previously (Sarati et al 2012). All compounds, except [ 14 C (U)]-l-arginine monohydrochloride (346 mCi/mmol, Amersham Life Science), were purchased from Sigma Chemic.…”

Section: Nitric Oxide Synthase Activitymentioning

confidence: 99%

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Thyroid disorders and nitric oxide in cardiovascular adaptation to hypovolemia

Ogonowski

Piro

Pessah

et al. 2016

Journal of Endocrinology

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This study aimed to investigate whether nitric oxide participates in the cardiovascular function and haemodynamic adaptation to acute haemorrhage in animals with thyroid disorders. Sprague-Dawley rats aged 2months old treated with T3 (hyper, 20μg/100g body weight) or 0.02% methimazole (hypo, w/v) during 28days were pre-treated with NG nitro-l-arginine methyl ester (L-NAME) and submitted to 20% blood loss. Heart function was evaluated by echocardiography. Measurements of arterial blood pressure, heart rate, nitric oxide synthase activity and protein levels were performed. We found that hypo decreased fractional shortening and ejection fraction and increased left ventricle internal diameter. Hyper decreased ventricle diameter and no changes in cardiac contractility. Haemorrhage elicited a hypotension of similar magnitude within 10min. Then, this parameter was stabilized at about 30–40min and maintained until finalized, 120min. L-NAME rats showed that the immediate hypotension would be independent of nitric oxide. Nitric oxide synthase inhibition blunted the changes of heart rate induced by blood loss. Hyper and hypo had lower atrial enzyme activity associated with a decreased enzyme isoform in hypo. In ventricle, hyper and hypo had a higher enzyme activity, which was not correlated with changes in protein levels. Haemorrhage induced an increased heart nitric oxide production. We concluded that thyroid disorders were associated with hypertrophic remodelling which impacted differently on cardiac function and its adaptation to a hypovolemia. Hypovolemia triggered a nitric oxide synthase activation modulating the heart function to maintain haemodynamic homeostasis. This involvement depends on a specific enzyme isoform, cardiac chamber and thyroid state.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 73%

Section: Nitric Oxide Synthase Activitymentioning

confidence: 99%

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Thyroid disorders and nitric oxide in cardiovascular adaptation to hypovolemia

Ogonowski

Piro

Pessah

et al. 2016

Journal of Endocrinology

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“…4 SH is also considered either experimentally and clinically to be a definite risk factor for overall cardiovascular aging and disease. 5,6 Accordingly, there are data that associate hypothyroid status to enhanced oxidative stress. [7][8][9] However, this issue is far from being completely settled in that, for instance, when hypothyroid rats were treated with 3,3¢,5-triiodothyronine (T3), a significant increase in the level of oxidative stress parameters in the mitochondrial fraction (MF) was recorded in adult rat brain.…”

mentioning

confidence: 99%

The Hidden Phenomenon of Oxidative Stress During Treatment of Subclinical-Mild Hypothyroidism: A Protective Nutraceutical Intervention

Tomella¹,

Catanzaro

Illuzzi³

et al. 2014

Rejuvenation Research

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Recent studies suggest that subjects with hypothyroidism under therapy with levothyroxine (L-T4) might develop oxidative stress. The aim of this study was to test a redox-balance modulator, fermented papaya-based nutraceutical (FPP), together with subclinical (SH) or mild hypothyroidism (MH) treatment in view of biochemical changes. A total of 60 females treated for SH-MH were divided into two matched groups and received either FPP 3 grams 1 sachet three times a day (t.i.d.) or placebo for 3 months. A significant baseline increase of all oxidative markers was observed in SH-MH ( p < 0.05 vs. control) and even more under T4 treatment ( p < 0.05). FPP caused a normalization of redox markers ( p < 0.01 vs. placebo). Thyroid supplementation accelerates mitochondrial oxygen consumption and oxidative stress, whereas a redox-modulator therapy is advisable, given the long-lasting treatment in such cases.

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“…NO prevent of oxygen disruption in mitochondria and also lipid peroxidation (O'Donnell et al 1997). On the other hand, it has been reported that in hypothyroidism the expression of NOS increase age dependently (Sarati et al 2012). Moreover a study showed that after PTU administration, eNOS content is increased in the rat aorta (Grieve et al 1999).…”

Section: Discussionmentioning

confidence: 97%

Comparison of therapeutic effects of L-Thyroxin, apelin and a combination of both on antioxidant enzymes in the heart of PTU-induced hypothyroid rats

Shahrivar

Badavi

Dianat

et al. 2016

Braz. arch. biol. technol.

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Atherosclerosis is one of the common disorders among hypothyroidism (TAC). Therefore, this study was conducted to assess, therapeutic effects of apelin, T4 (L-Thyroxin) or both on antioxidant capacity in 6-propyl-2-thiouracil (PTU)-induced hypothyroid rats. Forty male Wistar rats were randomly assigned into five groups: C: control group; P group (hypothyroid): PTU (0.05 %) administration for six weeks; P+A, P+T and P+A+T groups: after 4 weeks of PTU administration, animals treated with Apelin (200 μg/kg/day, ip) T4 (0.02 µg/g/day, gavage) and apelin+T4; for two weeks respectively accompanied by PTU administration. Aplein administration in P+A group and P+A+T group had beneficial effect to lowering of malondialdehyde (MDA) content as compared to hypothyroid group (8.52±0.64 and 8.53±1 vs. 13.67±1.64 nmol/g tissue, P<0.05) and also had increasing effect on Superoxide dismutase (SOD) and glutathion peroxidase (GPx) activity and the total antioxidant capacity (TAC) content compared to the hypothyroid group. This study showed that apelin was able to improve the oxidant-antioxidant balance in the heart tissue of the hypothyroid rats by elevating of antioxidant enzyme activity.

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Hypothyroidism: age-related influence on cardiovascular nitric oxide system in rats

Cited by 21 publications

References 32 publications

Thyroid disorders and nitric oxide in cardiovascular adaptation to hypovolemia

Thyroid disorders and nitric oxide in cardiovascular adaptation to hypovolemia

The Hidden Phenomenon of Oxidative Stress During Treatment of Subclinical-Mild Hypothyroidism: A Protective Nutraceutical Intervention

Comparison of therapeutic effects of L-Thyroxin, apelin and a combination of both on antioxidant enzymes in the heart of PTU-induced hypothyroid rats

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