Hypothetical Pathway of Nitrogen Metabolism

Costa, Giovanni

doi:10.1038/188549a0

Cited by 35 publications

(9 citation statements)

References 8 publications

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“…Furthermore, it has been shown that the nitrogen retention may not be followed by growth during long-term HGH administration (22). Recently the concept that nitrogen "retention" is adequately reflected by the difference between dietary intake and urine and stool excretion has been challenged (45,46). There is evidence that urine and stool excretion may not be the only sources of nitrogen loss from the body, since excess nitrogen or ammonia is also present in expired air (46)(47)(48).…”

Section: Discussionmentioning

confidence: 99%

Metabolic effects of human growth hormone in corticosteroid-treated children

Morris¹,

Jørgensen²,

Elrick³

et al. 1968

J. Clin. Invest.

101

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A B S T R A C T The effects of administered human growth hormone (HGH) were evaluated in dwarfed, prepubertal children who were receiving long-term corticosteroid therapy for a chronic disease. During 11 complete metabolic balance studies, the eight corticosteroid-treated children demonstrated impaired response to large doses of HGH with minimal nitrogen and no phosphorus retention. In contrast, two hypopituitary subjects and two asthmatic children not receiving corticosteroid responded to the same preparations of HGH with nitrogen, potassium, and phosphorus retention. Six corticosteroid-treated children were given large doses of HGH (40-120 mg/wk for 4 to 8 months and showed no improvement in their retarded rate of growth, whereas the hypopituitary subjects showed accelerated growth during administration of 10-15 mg of HGH/wk. It is concluded that dwarfism in steroid-treated children results from corticosteroid-induced antagonism of the effects of HGH at the peripheral tissue level.

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Section: Discussionmentioning

confidence: 99%

Metabolic effects of human growth hormone in corticosteroid-treated children

Morris¹,

Jørgensen²,

Elrick³

et al. 1968

J. Clin. Invest.

101

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“…Positive nitrogen retention values have been reported occasionally without corresponding gain in weight (Costa, 1960;Holmes et al, 1962).…”

Section: Requirements For Reproductionmentioning

confidence: 99%

Threonine Requirement for Reproduction in Swine

Leonard¹,

Speer²

1983

Journal of Animal Science

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“…Nitrogen balance was strongly positive during the HPD, particularly in the nephrotic patients, but the lack of an increase in body weight suggests that nitrogen retention was less than predicted from the B N measurements. Data from mice, rats, dogs, and humans fed high nitrogen intakes have demonstrated the same phenomenon (40)(41)(42). For instance, when healthy adults were fed 26-34 grams N/d for 28 to 42 d, B N remained strongly positive (up to ϩ7.9 grams N/d), yet body weight and total body potassium did not increase to the degree predicted by the retained nitrogen (42).…”

Section: Discussionmentioning

confidence: 85%