Hypothetical Mechanism of Skin Argyria

Abstract

Introduction. Argyria is an acquired skin condition that appears after the exposure or consumption of silver, leading to blue or grey coloration of the skin and mucosa. The aim of the present work was to draw researchers’ attention to two aspects of the argyria that until now have not received enough consideration. They are: (1) the process of delivering silver compound from the gastrointestinal tract to the skin and (2) the possibility for silver chloride to participate in this process along with the silver proteinates. Methodology. Illustrative experiments included the observation of color change (visual and using UV-Vis spectrometry) under different light exposure conditions of silver chloride sol in a sweat-simulating solution, in vials and under pig skin (in direct contact). Results and Discussion. A hypothetical mechanism based on a perspiration system for delivering the silver compounds from the gastrointestinal tract to the skin for argyria was proposed. It was also proposed not to completely exclude the partial participation of silver chloride along with the silver proteinates in this process.

Metallogels from Silver Nanoparticles and Peptide Nanofibers as Antimicrobial Surfaces

“…39 Extended exposure to silver nanomaterials can lead to the deposition of silver as an insoluble compound under skin, leading to diseases like argyria. 40,41 As Ag NPs and Ag NCs tend to aggregate to form bulk silver, researchers started to devise strategies to stabilize them in a closed network system. 42−45 Ag NPs protected by small molecules may show high antimicrobial effects but possess threat of accumulation and toxicity as excretion of these materials from our body is difficult.…”

“…Unfortunately, their cytotoxicity has limited the application for internal usages . Extended exposure to silver nanomaterials can lead to the deposition of silver as an insoluble compound under skin, leading to diseases like argyria. , As Ag NPs and Ag NCs tend to aggregate to form bulk silver, researchers started to devise strategies to stabilize them in a closed network system. − Ag NPs protected by small molecules may show high antimicrobial effects but possess threat of accumulation and toxicity as excretion of these materials from our body is difficult. On the other hand, despite the excellent biocompatible nature of peptide-based antibacterial gels, they do not generally exhibit broad-spectrum bacteria killing.…”

Argiria secundária ao uso de curativos com prata coloidal: relato de caso e revisão da literatura

“…3 Os mecanismos exatos da penetração da prata nos tecidos permanecem desconhecidos, mas formula-se a hipótese do envolvimento de complexos de cloreto de prata secretados junto ao suor em camadas superficiais dérmicas, o que justificaria a alta concentração de grânulos de prata ao redor de glândulas écrinas da derme. 4,5,17,18 Em região dérmica, a prata iônica sofre subsequente redução catalisada por fotoexposição, formando partículas de prata metálica. Após a prata metálica ser oxidada no tecido, se liga e se transforma nas formas de seleneto e sulfeto de prata, que são compostos quimicamente estáveis e com baixa solubilidade.…”

“…: hemossiderose, doença de Wilson, doença de Addison) e causas exógenas, como intoxicações por outros metais (mercúrio, arsênio e ouro) ou secundários a drogas específicas como clorpromazina, amiodarona e antimaláricos, devendo-se ser descartado também nevos azuis, ocronose e disfunções perfusionais que possam acarretar em cianose de extremidades. 15,20 A pigmentação cutânea típica da argiria é permanente, na qual a prata se deposita na derme em uma forma inativa e quimicamente estável, não havendo tratamento definitivo para essa condição 17 Uma vez realizado o diagnóstico de argiria, nenhum tratamento adicional é necessário, exceto por razões cosméticas. O principal problema é o incômodo estético, que pode causar constrangimento e afastamento social.…”

“…O principal problema é o incômodo estético, que pode causar constrangimento e afastamento social. 17 . Acúmulo de prata na pele e nas membranas mucosas tem um impacto negativo na qualidade de vida dos pacientes devido a um aspecto estético desfavorável.…”