Hypothetical HTLV-I induction by ionizing radiation

Kanzaki, Luis Isamu Barros

doi:10.1016/j.mehy.2006.01.017

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Nevertheless, the human cultural development accompanied by population growth which consequently moved huge mass of people to more developed towns adding high levels of demographic density imposing exaggerated levels of stress and besides these factors, the advances in preventive and curative medicine have selected all kind of microorganisms by the survival of their human hosts. Also, climatic changes with elevated exposition to different wave length radiations, mainly ionizing radiation, have played an important role in the mutation rate of all kind of genetic elements in acellular and cellular organisms [28]. Henceforth, taking in account all the facts mentioned, evolution has been in fast course and ultimately it seems to be in a rush at least in our knowledge of the modern civilization, in a way that apathogenic deltaretroviruses have been claimed to be involved in a large spectrum of diseases [29].…”

Section: Human Deltaretroviruses Evolution and Human Diseasementioning

confidence: 99%

Human T-Lymphotropic Viruses Evolution Possibly Explained by Primate Deltaretrovirus Geographical Segregation

Kanzaki

Casseb²

2008

Retrovirology: Research and Treatment

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The primate T cell lymphotropic virus group comprises pathogenic and apathogenic agents found in human and simian hosts. Up to date, three types of the simian T cell lymphotropic virus/STLV and four types of the human T cell lymphotropic virus/HTLV have been isolated and characterized from non human primates and from human hosts respectively. We have not found evidences of STLV-1 infection among new world monkeys and besides fi ndings of HTLV-1 and HTLV-2 infection among brazilian mixed ethnic populations and Amerindians respectively, some unresolved HTLV indeterminate-Western blot results prevailed among human groups of different ethnic background. Based on recent serologic detection, isolation and characterization of HTLV-3 and HTLV-4 among African populations in central Africa and additional unrefutable evidences of early human migration from Africa and Australia to the American continent previously of Asiatic population migration lead us to hypothesize that human descendents of mixed Amerinds and Africans or remaining Africans explain the very frequent presence of Western blot-indeterminate results for HTLV-1/2 that we and other groups have been detecting and also the unusual absence of HTLV-2 infection among some relatively homogeneous ethnic native human populations in the American continent.

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Section: Human Deltaretroviruses Evolution and Human Diseasementioning

confidence: 99%

Human T-Lymphotropic Viruses Evolution Possibly Explained by Primate Deltaretrovirus Geographical Segregation

Kanzaki

Casseb²

2008

Retrovirology: Research and Treatment

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“… 1 This virus is endemic to several areas including: southwestern Japan, the Caribbean, inter-tropical Africa, the Middle East, South America, and Papua New Guinea. 2 , 3 It can cause two different diseases, adult T-cell leukemia lymphoma (ATL) and HTLV-1-associated myelopathy-tropical spastic paraparesis. 3 The former, ATL, is a malignant condition affecting the patient described in this case, whereas, the latter is an inflammatory central nervous system (CNS) condition.…”

Section: Introductionmentioning

confidence: 99%

“…There are four subtypes of ATL, which differ in clinical presentation and prognosis: acute and lymphoma, the more aggressive subtypes, and smoldering and chronic, the more indolent subtypes. 2 , 3 The patient was ultimately diagnosed with HTLV associated Acute ATL presentation with organomegaly, lymphadenopathy, an elevated lactate dehydrogenase (LDH) level, and circulating malignant cells, and hypercalcemia, with opportunistic pulmonary infections in a minority of cases as well. 4 , 5 Approximately 10-20 million people are currently infected by the HTLV virus.…”

Section: Introductionmentioning

confidence: 99%

Palliative Radiation for Leukemic Arthropathy from Human T-Cell Lymphoma Virus-associated Adult T-Cell Leukemia Lymphoma

et al. 2015

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Human T-cell lymphoma virus (HTLV)-associated adult T-cell leukemia lymphoma is a rare cancer in the United States, but there are several areas around the world where the virus is endemic. HTLV-associated adult T-cell leukemia lymphoma has been associated with leukemic arthropathy. We present a patient with HTLV-associated adult T-cell leukemia lymphoma with leukemic arthropathy. Although non-steroidal anti-inflammatory drugs and chemotherapy are often used for treatment, we describe the successful use of radiation therapy in the palliative relief of symptoms from leukemic arthropathy.

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HTLV-1: A real pathogen or a runaway guest of a diseased cell?

Kanzaki

2018

J Biosci

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The human T-cell lymphotropic virus type 1 (HTLV-1) is a deltaretrovirus claimed to be aetiologically linked to the adult T-cell leukaemia/lymphoma (ATLL) and associated myelopathy/tropical spastic paraparesis (HAM/TSP) besides other minor pathologies. HTLV-1 infection is worldwide distributed, despite its heterogeneous prevalence. Environmental factors and host-genetic background are very likely to determine the epidemiological profile of HTLV-1 prevalence and related disease confinement in distinct human ethnic populations and geographical coordinates, which raises the question if the virus is a real pathogen or a runaway well-organized packed genome of a burden host cell near death process. New methodological approaches need to be proposed and applied in order to prove or discard the hypotheses emerged in the present review.

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Hypothetical HTLV-I induction by ionizing radiation

Cited by 5 publications

References 35 publications

Human T-Lymphotropic Viruses Evolution Possibly Explained by Primate Deltaretrovirus Geographical Segregation

Human T-Lymphotropic Viruses Evolution Possibly Explained by Primate Deltaretrovirus Geographical Segregation

Palliative Radiation for Leukemic Arthropathy from Human T-Cell Lymphoma Virus-associated Adult T-Cell Leukemia Lymphoma

HTLV-1: A real pathogen or a runaway guest of a diseased cell?

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