Hypothesis: The central medial amygdala may be implicated in sudden unexpected death in epilepsy by melanocortinergic–sympathetic signaling

H, Yan; Guan, Xue-Hai; Liu, Taotao; He, Zhigang; Xiang, Hong‐Bing

doi:10.1016/j.yebeh.2014.09.017

Cited by 11 publications

(3 citation statements)

References 29 publications

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“…Impairments associated with myocardial ischemia can be categorized into nociceptive [13,14] and affective domains [15]. The first domain is associated with brain regions that most consistently involve the amygdala, thalamus, cortex, anterior singular cortex (ACC), periaqueductal gray and rostral ventromedial medulla (RVM) [15][16][17][18][19]. Structures more critically involved in MIRI, may include the brainstem [19,20] and thalamic nucleus [7,21].…”

Section: Agingmentioning

confidence: 99%

Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Mao

Wang

et al. 2020

Aging

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Background: Recent studies have demonstrated a complex and dynamic neural crosstalk between the heart and brain. A heart-brain interaction has been described regarding cardiac ischemia, but the cerebral metabolic mechanisms involved are unknown. Methods: Male Sprague Dawley rats were randomly allocated into 2 groups: those receiving myocardial ischemia-reperfusion surgery (IR group, n =10) and surgical controls (Con group, n=10). These patterns of metabolic abnormalities in different brain regions were assessed using proton magnetic resonance spectroscopy (PMRS). Results: Results assessed by echocardiography showed resultant cardiac dysfunction following heart ischemia-reperfusion. Compared with the control group, the altered metabolites in the IR group were taurine and choline, and differences mainly occurred in the thalamus and brainstem. Conclusions: Alterations in cerebral taurine and choline are important findings offering new avenues to explore neuroprotective strategies for myocardial ischemia-reperfusion injury. These results provide preliminary evidence for understanding the cerebral metabolic process underlying myocardial ischemia-reperfusion injury in rats.

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Section: Agingmentioning

confidence: 99%

Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Mao

Wang

et al. 2020

Aging

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“…There is growing evidence that sudden unexpected death in epilepsy (SUDEP) involves different intrinsic vulnerabilities of brain regions and/or environmental factors [1][2][3][4][5]. In recent years, research from many laboratories related to epilepsy has shown that the neural circuits are homeostatically regulated [6][7][8].…”

Section: To the Editormentioning

confidence: 99%

“…Recently, our results from a previous study showed that the amygdala may be implicated in sudden unexpected death in epilepsy by melanocortinergic-sympathetic signaling [2,9]. It is known that the amygdala is an important brain region that plays a central role in emotional disorders and associated sympathetic behavior [4,10].…”

Section: Amygdala and Sudden Unexpected Death In Epilepsymentioning

confidence: 99%

Hypothesis: CeM–RVLM circuits may be implicated in sudden unexpected death in epilepsy by melanocortinergic–sympathetic signaling

Liu

et al. 2015

Epilepsy & Behavior

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Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling

Song

Liu

et al. 2015

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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Substantial evidence has suggested that deep brain stimulation of the cuneiform nucleus has become a remarkable treatment option for intractable pain, but the possible mechanism is poorly understood. Using a melanocortin-4 receptor (MC4R)-green fluorescent protein (GFP) reporter knockin mouse, we showed that a large number of MC4R-GFP-positive neurons were expressed in the cuneiform nucleus. Immunofluorescence revealed that approximately 40%-50% of MC4R-GFP-positive neurons expressed mu opioid receptors, indicating that they were opioidergic signaling. Our findings support the hypothesis that MC4R expression in the cuneiform nucleus is involved in the modulation of opioidergic signaling.

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Hypothesis: The central medial amygdala may be implicated in sudden unexpected death in epilepsy by melanocortinergic–sympathetic signaling

Cited by 11 publications

References 29 publications

Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Neurochemical alterations of different cerebral regions in rats with myocardial ischemia-reperfusion injury based on proton nuclear magnetic spectroscopy analysis

Hypothesis: CeM–RVLM circuits may be implicated in sudden unexpected death in epilepsy by melanocortinergic–sympathetic signaling

Melanocortin-4 receptor expression in the cuneiform nucleus is involved in modulation of opioidergic signaling

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