Hypothesis: Oxytocin is a direct COVID-19 antiviral

Diep, Phuoc-Tan; Talash, Khojasta; Kasabri, Violet

doi:10.1016/j.mehy.2020.110329

Cited by 15 publications

(12 citation statements)

References 8 publications

(6 reference statements)

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“…Furthermore, activation of the oxytocin receptor, also expressed in the pulmonary artery, can produce a vasodilatory effect by enhancing the nitroxide pathway [59]. Moreover, oxytocin has been demonstrated to be a natural inhibitor of dipeptidyl-peptidase IV and may have a potential role in contrasting coronaviruses' internalization into host cells [60].…”

Section: Hypothalamus and Pituitary Glandmentioning

confidence: 99%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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: Background and aim. The review aimed to summarize advances in the topic of endocrine diseases and coronavirus disease 2019 (COVID-19). Methods. Scientific and institutional websites and databases were searched and data were collected and organized, when plausible, to angle the discussion toward the following clinical issues. (1) Are patients with COVID-19 at higher risk of developing acute or late-onset endocrine diseases or dysfunction? (2) May the underlying endocrine diseases or dysfunctions be considered risk factors for poor prognosis once the infection has occurred? (3) Are there defined strategies to manage endocrine diseases despite pandemic-related constraints? Herein, the authors considered only relevant and more frequently observed endocrine diseases and disorders related to the hypothalamic-pituitary region, thyroid and parathyroid glands, calcium-phosphorus homeostasis and osteoporosis, adrenal glands, and gonads. Main. Data highlight the basis of some pathophysiological mechanisms and anatomical alterations of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-induced endocrine dysfunctions. Some conditions, such as adrenal insufficiency and cortisol excess, may be risk factors of worse clinical progression once the infection has occurred. These at-risk populations may require adequate education to avoid the SARS-CoV-2 infection and adequately manage medical therapy during the pandemic, even in emergencies. Endocrine disease management underwent a palpable restraint, especially procedures requiring obligate access to healthcare facilities for diagnostic and therapeutic purposes. Strategies of clinical triage to prioritize medical consultations, laboratory, instrumental evaluations, and digital telehealth solutions should be implemented to better deal with this probably long-term situation.

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Section: Hypothalamus and Pituitary Glandmentioning

confidence: 99%

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Lisco

Tullio

Stragapede

et al. 2021

JCM

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“…Chittepu et al proposed oxytocin as a natural inhibitor of DPP4, demonstrating its inhibitory potential on the biological activity of DPP4 through molecular docking studies [ 170 ]. Based on this evidence, Diep et al advanced the hypothesis that oxytocin may be a direct viral inhibitor against SARS-CoV-2 [ 171 ]. Anti-inflammatory and pro-immune properties have been associated with oxytocin through studies on carbetocin, its structural analogue and peripheral agonist of the oxytocin receptor.…”

Section: Oxytocin Signaling and Inflammation Occurring In Chronic Diseasesmentioning

confidence: 99%

Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases

Friuli

Eramo

Valenza

et al. 2021

IJMS

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Unresolved inflammation represents a central feature of different human pathologies including neuropsychiatric, cardiovascular, and metabolic diseases. The epidemiologic relevance of such disorders justifies the increasing interest in further understanding the mechanisms underpinning the inflammatory process occurring in such chronic diseases to provide potential novel pharmacological approaches. The most common and effective therapies for controlling inflammation are glucocorticoids; however, a variety of other molecules have been demonstrated to have an anti-inflammatory potential, including neuropeptides. In recent years, the oxytocinergic system has seen an explosion of scientific studies, demonstrating its potential to contribute to a variety of physiological processes including inflammation. Therefore, the aim of the present review was to understand the role of oxytocin in the modulation of inflammation occurring in different chronic diseases. The criterion we used to select the diseases was based on the emerging literature showing a putative involvement of the oxytocinergic system in inflammatory processes in a variety of pathologies including neurological, gastrointestinal and cardiovascular disorders, diabetes and obesity. The evidence reviewed here supports a beneficial role of oxytocin in the control of both peripheral and central inflammatory response happening in the aforementioned pathologies. Although future studies are necessary to elucidate the mechanistic details underlying such regulation, this review supports the idea that the modulation of the endogenous oxytocinergic system might represent a new potential pharmacological approach for the treatment of inflammation.

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“…Generally, oxytocin production decreases with age, which is linked to thymic involution. Oxytocin also has antiviral activity and it has been reported its possible used to treat CoVID-19 through DPP-inhibition mechanism of action [33,34].…”

Section: Phenotype Characteristics In Various Diseasesmentioning

confidence: 99%

Molecular Aspects and Structure Activity Relationship of Oxytocin Agonists and Antagonist’s Role in Health

Chittepu¹,

Kalhotra²,

Gallardo-Velázquez³

et al. 2021

Oxytocin and Health

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Oxytocin (OT) and Oxytocin receptor signaling mechanism had emerged as a pathway for treatment of metabolic disorders like obesity, and diabetes. Both agonists and antagonists activity of the oxytocin receptor has beneficial aspects. This chapter will outline the receptor agonists and antagonist’s activity as a function of the features: hydrophobic regions, activity shapes, and positive and negative electrostatics. Also, their phenotype characteristics in various diseases like diabetes, obesity, cardiovascular and immune related diseases will be outlined. Finally, therapeutic development strategies for using various nanomaterials, and other biomaterials, as well as those in present use will be discussed.

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Hypothesis: Oxytocin is a direct COVID-19 antiviral

Cited by 15 publications

References 8 publications

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

COVID-19 and the Endocrine System: A Comprehensive Review on the Theme

Targeting the Oxytocinergic System: A Possible Pharmacological Strategy for the Treatment of Inflammation Occurring in Different Chronic Diseases

Molecular Aspects and Structure Activity Relationship of Oxytocin Agonists and Antagonist’s Role in Health

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