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Cited by 29 publications
(13 citation statements)
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“…macrophages that have ingested leftover melanin pigment. While it has been proposed that immune cell mediated killing of melanoma cells is the main mechanism leading to melanoma regression, telomere crisis has been proposed as an alternative mechanism (46). …”
Section: Melanocytic Neoplasms Originating From Epithelial Melanocytesmentioning
confidence: 99%
“…macrophages that have ingested leftover melanin pigment. While it has been proposed that immune cell mediated killing of melanoma cells is the main mechanism leading to melanoma regression, telomere crisis has been proposed as an alternative mechanism (46). …”
Section: Melanocytic Neoplasms Originating From Epithelial Melanocytesmentioning
confidence: 99%
“…42,43 Other factors that can induce melanoma regression include decreased microphthalmia transcription factor activity within melanocytes. 44 Another mechanism, proposed by Bastian,45 suggests that decreased telomerase activity can lead to abnormal telomere function, and thus induce replicative senescence in melanoma cells, resulting in the generation of apoptotic bodies and a T lymphocyte response.…”
Section: Spontaneous Regression In Melanomamentioning
confidence: 99%
“…Although the current understanding of regression is clearly that of an immune-mediated, cancer-autonomous process [21], neither its biological significance nor the underlying molecular or genomic aberrations are so far recognized. Possible explanations vary from an increased T-cell response [54], an inhibited angiogenesis [53], to a forced apoptosis of tumor cells [53, 55]. Consequently there are different therapeutical implications of regression.…”
Section: Clinicopathological Parameters In Malignant Melanomamentioning
confidence: 99%
“…Especially in thin melanomas <1 mm, regression as a left-over of a presumably thicker tumor therefore still leads to wider surgical margins and a lower threshold for SLN biopsy [58]. The most convincing, although unproven, hypotheses for a regression-driven tumor progression so far are the Hammon's effect, which postulates a natural selection of aggressive residual tumor clones as a result of regression [59, 60] and Bastian's telomere crisis, which argues that a massive senescence and cellular apoptosis equally favor the selection of genomic aberrations and therefore progression [55]. Future epidemiologic studies investigating the impact of regression of the primary tumor for the prognosis of melanoma are certainly required to further investigate those intriguing details.…”
Section: Clinicopathological Parameters In Malignant Melanomamentioning
confidence: 99%