Hypothesis: a novel route for immortalization of epithelial cells by Epstein-Barr virus

Gao, Yanning; Lu, Yong‐Jie; Xue, Shao-An; Chen, Honglin; Wedderburn, Nina; Griffin, Beverly E.

doi:10.1038/sj.onc.1205130

Cited by 25 publications

(10 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the EBV primary infection has been delayed in the infants from Hong Kong and the consumption of salted fish that contain plenty of nitrosamine has been decreased, the NPC incidence in Hong Kong has declined [23]–[25]. This indicates the interplay between the delay of primary EBV infection and lower NPC morbidity in adulthood.…”

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus (EBV) Infection in Chinese Children: A Retrospective Study of Age-Specific Prevalence

et al. 2014

View full text Add to dashboard Cite

BackgroundEpstein-Barr Virus (EBV) is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retrospective study was to collect baseline information about the prevalence of EBV infection in Chinese children.Methodology/Principal FindingWe collected 1778 serum samples from healthy children aged 0 to 10, who were enrolled in conventional health and nutrition examinations without any EBV-related symptom in 2012 and 2013 in North China (n = 973) and South China (n = 805). We detected four EBV-specific antibodies, i.e., anti-VCA-IgG and IgM, anti-EBNA-IgG and anti-EA-IgG, by ELISA, representing all of the phases of EBV infection. The overall EBV seroprevalence in samples from North and South China were 80.78% and 79.38% respectively. The EBV seropositivity rates dropped slightly at age 2, and then increased gradually with age. The seroprevalence became stabilized at over 90% after age 8. In this study, the seroprevalence trends between North and South China showed no difference (P>0.05), and the trends of average antibody concentrations were similar as well (P>0.05).Conclusions/SignificanceEBV seroprevalence became more than 50% before age 3 in Chinese children, and exceed 90% after age 8. This study can be helpful to study the relationship between EBV and EBV-associated diseases, and supportive to EBV vaccine development and implementation.

show abstract

Section: Discussionmentioning

confidence: 99%

Epstein-Barr Virus (EBV) Infection in Chinese Children: A Retrospective Study of Age-Specific Prevalence

et al. 2014

View full text Add to dashboard Cite

show abstract

“…BARF1 is frequently detected in NPC, gastric carcinoma and even endemic BL as a latent secreted protein (186,(194)(195)(196)(197)(198), but not in HL (P Murray, unpublished). BARF1 shares some homology with the colony-stimulating factor 1 receptor (the FMS oncogene) and displays oncogenic activity when expressed in rodent fibroblasts and simian primary epithelial cells (199,200). The secreted form of BARF1 can activate cell cycle as a growth factor (201).…”

Section: Barts and Barf1mentioning

confidence: 99%

Epstein-Barr virus (EBV) and its associated human cancers - Genetics, epigenetics, pathobiology and novel therapeutics

Tao¹

2006

Front Biosci

118

121

View full text Add to dashboard Cite

Epstein-Barr virus (EBV) is a B-lymphotropic virus that is associated with a range of human malignancies. Although for many of these tumors the association has long been established, unraveling the precise role of EBV in disease pathogenesis has been more difficult. This review summarizes current knowledge concerning the association between EBV and human cancers, and illustrates how a deeper insight into viral latent gene expression, regulation and functions in different cell environments is already helping towards a better understanding of both the natural history of infection in normal individuals and how EBV contributes to malignant transformation. Finally, therapeutic strategies targeting EBV in tumors are discussed.

show abstract

“…Furthermore, it has been found in breast tissue and is frequently found in breast secretions including breast milk [12]. EBV can infect mammary epithelial cells and its DNA fragment (p31) is capable of inducing immortalization in these cells [13]. This cosmopolitan γ-herpes virus infects usually at younger age.…”

Section: Ebv Infection Molecular Interaction and Latencymentioning

confidence: 99%

Breast Cancer as an Epstein-Barr Virus (EBV)-Associated Malignancy

Fessahaye¹,

Ibrahim²

2017

Breast Cancer - From Biology to Medicine

View full text Add to dashboard Cite

The Epstein Barr Virus is among the very first oncogenic viruses to be identified as culprits of human malignancies. Its role as an etiologic agent of breast cancer however remains debated despite mounting molecular evidence. In this chapter we address the challenge of multiple molecular etiologies of breast cancer (BC) with emphasis on the Epstein Barr Virus (EBV) as a potential causative agent within a frame work of gene/environment interaction. We also hope to contribute to a critique of the a concept of universal single agent or gene in cancer etiology. In addition to reviewing further reasons of why EBV should be considered a tumor virus, coupling molecular targets at the initiation stage, we examine evidence for the culpability of EBV as oncogenic virus in relation to the genetic and epigenetic events that leads to carcinogenesis of cancer; and the subsequent downstream interaction including genetic and epigenetic modifiers of signaling and molecular function underlying the cancerous phenotype. The TNF family is taken as an example of how the epigenetic reprogramming process, impacts molecular targets and how these combined interplay of molecular events impinges on pathogenesis and malignancy of breast cancer in humans.

show abstract

Hypothesis: a novel route for immortalization of epithelial cells by Epstein-Barr virus

Cited by 25 publications

References 62 publications

Epstein-Barr Virus (EBV) Infection in Chinese Children: A Retrospective Study of Age-Specific Prevalence

Epstein-Barr Virus (EBV) Infection in Chinese Children: A Retrospective Study of Age-Specific Prevalence

Epstein-Barr virus (EBV) and its associated human cancers - Genetics, epigenetics, pathobiology and novel therapeutics

Breast Cancer as an Epstein-Barr Virus (EBV)-Associated Malignancy

Contact Info

Product

Resources

About