Hypothesis

Hecht, Eric M.; Landy, David C.; Ahn, Soyeon; Hlaing, Way Way M.; Hennekens, Charles H.

doi:10.1177/1074248413494815

Cited by 38 publications

(13 citation statements)

References 36 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are compatible with earlier investigations [3-6]. The plausibility of these findings is enhanced by observations that cadmium is a metal found in abundance in cigarette smoke and has been hypothesized to have cardiovascular toxicity [7]. After absorption into the circulation, cadmium infiltrates the medial layers of the arterial vasculature, where it is estimated to have a biological half-life of many decades [8].…”

Section: Introductionsupporting

confidence: 82%

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

et al. 2018

View full text Add to dashboard Cite

The interrelationships between cadmium biomarker levels, smoking, and myocardial infarction and stroke have been established. In this cross-sectional analysis, we explored the interrelationships of blood cadmium levels, smoking, and angina. We analyzed the National Health and Nutrition Examination Survey (NHANES, 2003–2014) accounting for the multi-staged complex sampling design. Participants 40–79 years of age with blood cadmium levels but without a history of myocardial infarction and/or stroke were included (n = 14,832). We examined blood cadmium levels (3 tertile groups) in relation to 3 (diagnosed, undiagnosed, and composite diagnosed and/or undiagnosed) angina outcomes. Multivariable logistic regression models adjusted for age, diabetes, smoking status, and household income were used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Of 14,832 participants, 741 (4.2%) had positive composite angina. The crude and adjusted ORs comparing those in the lowest tertile (referent group) of blood cadmium to those in the highest tertile for the composite outcome were 1.82 (95% CI 1.42–2.34) and 1.45 (95% CI 1.12–1.88), respectively. These cross-sectional data from a nationally representative sample contribute to the hypothesis that there are interrelationships between smoking, cadmium, and angina.

show abstract

Section: Introductionsupporting

confidence: 82%

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

et al. 2018

View full text Add to dashboard Cite

show abstract

“…With tobacco being one of the susceptible plants to Cd stress, strategies for reducing Cd accumulation and the related health risks are urgently desired [3,4]. GB is water-soluble, nontoxic, and environmentally safe.…”

Section: Discussionmentioning

confidence: 99%

“…Tobacco ( Nicotiana tabacum L.) is one of the most economically important crops worldwide. However, it is more acclimated to Cd uptake than other crops and preferentially enriches Cd in leaves, readily causing a risk for human health through the inhalation of smoke from cigarettes [3]. It has been demonstrated that Cd-exposed populations through smoking has a 2–3 folds higher morbidity risk of peripheral arterial disease than those of nonsmokers [4].…”

Section: Introductionmentioning

confidence: 99%

Exogenous Glycinebetaine Reduces Cadmium Uptake and Mitigates Cadmium Toxicity in Two Tobacco Genotypes Differing in Cadmium Tolerance

Richmond

Williams

et al. 2019

IJMS

View full text Add to dashboard Cite

Greenhouse hydroponic experiments were conducted using Cd-sensitive (cv. Guiyan1) and Cd-tolerant (cv. Yunyan2) tobacco cultivars to study the ameliorative effects of exogenous glycinebetaine (GB) upon 5 μM Cd stress. The foliar spray of GB markedly reduced Cd concentrations in plants and alleviated Cd-induced soil plant analysis development (SPAD) value, plant height and root length inhibition, with the mitigation effect being more obvious in Yunyan2. External GB markedly reduced Cd-induced malondialdehyde (MDA) accumulation, induced stomatal closure, ameliorated Cd-induced damages on leaf/root ultrastructure, and increased the chlorophyll content and fluorescence parameters of Fo, Fm, and Fv/Fm in both cultivars and Pn in Yunyan2. Exogenous GB counteracted Cd-induced alterations of certain antioxidant enzymes and nutrients uptake, e.g., the depressed Cd-induced increase of superoxide dismutase (SOD) and peroxidase (POD) activities, but significantly elevated the depressed catalase (CAT) and ascorbate peroxidase (APX) activities. The results indicate that alleviated Cd toxicity by GB application is related to the reduced Cd uptake and MDA accumulation, balanced nutrients and antioxidant enzyme activities, improved PSII, and integrated ultrastructure in tobacco plants.

show abstract

“…Cd is an ubiquitous industrial and naturally occurring environmental contaminant resulting from anthropogenic activity; it poses toxic effects on lungs, liver, testicles, kidneys, and bone tissues [ 11 ]. Recently, Cd exposure was associated with multiple adverse health effects, including osteoporosis and fractures [ 43 , 44 ], renal dysfunction [ 45 , 46 ], atherosclerotic plaques [ 47 , 48 ], cancer [ 49 , 50 ], and cardiovascular diseases [ 51 , 52 ]. Cd is primarily considered a nephrotoxicant; however, numerous short- and long-term in vivo Cd exposure models showed that Cd can cause hyperglycemia and disrupt glucose homeostasis in experimental animals [ 39 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Song

Zhu³

et al. 2017

Oncotarget

View full text Add to dashboard Cite

Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, and cardiovascular disease. Several population-based studies found an association between Cd and diabetes mellitus (DM), but this association is inconsistent with other research. We conducted meta-analysis to examine relationship between urinary/blood Cd exposure and DM risk. Pertinent studies were identified by searching PubMed and Embase databases, and combined odds ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate said association. Meta-analysis showed that high U-Cd exposure is not correlated with DM risk (OR = 1.19; 95% CI = 0.83–1.71), and high B-Cd exposure is also not associated with increased risk of DM (OR = 1.16; 95% CI = 0.84-1.62) in the general population. Subgroup and sensitivity analysis proved similar results, with little evidence of publication bias. This meta-analysis suggests that high U-Cd/B-Cd exposure may not be risk factor for DM in general populations. However, large prospective studies are needed to confirm this finding.

show abstract

Hypothesis

Cited by 38 publications

References 36 publications

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

Exogenous Glycinebetaine Reduces Cadmium Uptake and Mitigates Cadmium Toxicity in Two Tobacco Genotypes Differing in Cadmium Tolerance

Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis

Contact Info

Product

Resources

About