Hypothermic Machine Perfusion of Liver Grafts Can Safely Extend Cold Ischemia for Up to 20 Hours in Cases of Necessity

Abstract

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Role of perfusion machines in the setting of clinical liver transplantation: A qualitative systematic review

“…Of the remaining 267, 240 were not considered eligible for full‐text evaluation. Eventually, 27 articles with a total number of 173 patients were reported on clinical LT using MP . Some articles from the same center showed partial overlapping of reported cases: consequently, the global number of patients for each center was extrapolated after careful evaluation of the reported series, typically taking into consideration the most recent study.…”

“…Focusing on the extension of the preservation time, 3 cases from Milan and Cambridge reached a global time from donor aortic flush to end of machine perfusion of 18.3, 18.8 and 20.0 hours, respectively . Being a record in this topic, the case described by Watson et al.…”

“…Since then, multiple experiences have been reported worldwide, fostering high expectations concerning the following implementation of MPs into clinical practice . However, several obstacles, as the necessity of finding objective MP‐related variables to select grafts suitable for LT, still stand.…”

Machine perfusion for liver transplantation in the era of marginal organs—New kids on the block

“…In 2017, Carlis et al published a case report on the extension of liver preservation times by DHOPE to 18 and 20 hours respectively. Two DBD grafts were perfused for logistic reasons after the CIT extended to 12 hours and exhibited a good function after OLT and at 5 months post‐OLT (Table ) …”

“…77 Based on these preliminary findings Two DBD grafts were perfused for logistic reasons after the CIT extended to 12 hours and exhibited a good function after OLT and at 5 months post-OLT (Table 3). 93 Donation after brain death is the only legal donation practice in Germany as well as many other countries and is still the largest pool of ECD allografts in the Western World. 94…”