Hypothermia induction and survival in hamsters: The role of temperature acclimation and an anesthetic (halothane)

Volkert, WA; Musacchia, X. J.

doi:10.1016/0011-2240(76)90119-x

Cited by 10 publications

(3 citation statements)

References 9 publications

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“…Future efforts could also be directed toward distinguishing between the changes in neuronal metabolism that are a result of decreased body temperature (i.e., Qlo effects) from those that are specific to hibernation. Rodents can be maintained in induced hypothermia at body temperatures comparable to those of hibernators for up to several days (Volkert and Musacchia, 1976). In contrast to the regulated decrease of body temperature characteristic of hibernation (Heller and Colliver, 1974;Heller et al, 1977), induced hypothermia is an unregulated state in which the animal's heat production capacity is overcome by extreme external conditions (Popovic and Popovic, 1974).…”

Section: Limitations Of the Current Studymentioning

confidence: 99%

14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation

et al. 1990

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Neuronal activity underlying various phases of the mammalian hibernation cycle was investigated using the 14C-2-deoxyglucose (2DG) method. Relative 2DG uptake (R2DGU) values were computed for 96 brain regions across 7 phases of the hibernation cycle: euthermia, 3 body temperature (Tb) intervals during entrance into hibernation, stable deep hibernation, and 2 Tb intervals during arousal from hibernation. Multivariate statistical techniques were employed to identify objectively groups of brain regions whose R2DGU values showed a similar pattern across all phases of hibernation. Factor analysis revealed that most of the variability in R2DGU values for the 96 brain regions across the entire cycle could be accounted for by 3 principal factors. These factors could accurately discriminate the various phases of hibernation on the basis of the R2DGU values alone. Three hypothalamic and 3 cortical regions were identified as possibly mediating the entrance into hibernation because they underwent a change in R2DGU early in entrance into hibernation and loaded strongly on one of the principal factors. Another 4 hypothalamic regions were similarly identified as possibly causally involved in the arousal from hibernation. These results, coupled with characteristic changes in ordinal rank of the 96 brain regions in each phase of hibernation, support the concept that mammalian hibernation is an active, integrated orchestration of neurophysiological events rather than a state entered through a passive process.

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Section: Limitations Of the Current Studymentioning

confidence: 99%

14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation

et al. 1990

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“…Sevoflurane is particularly useful for providing the condition of cold narcosis since the sevoflurane can be easily removed once the body temperature is low enough (22ºC). Using a similar experimental method, Volkert and Musacchia ( 1976 ) have shown that light anesthesia with halothane not only reduces the biological insult during induction of hypothermia but also greatly enhances the survival of hamsters recovering from hypothermia.…”

Section: Discussionmentioning

confidence: 99%

“…Although there is much evidence to show that breathing patterns are influenced by many factors such as age, size, species, and the choice of anesthetics (Milic‐Emili, 1977 ), to our knowledge, no study has dealt with the influence of anesthesia on the ability to autoresuscitate from hypothermic respiratory arrest in adult mammals that do not hibernate. There is some evidence to show that light anesthesia with halothane improves the ability to survive hypothermia in hibernating mammals (Volkert & Musacchia, 1976 ). In anesthetized animals, the inhibitory effects of hypothermia on respiratory activity might be magnified by the synergistic effects of anesthesia since the effects of anesthesia on metabolism and ventilation are to a certain extent analogous to the effects of hypothermia (Hagerdal et al, 1978 ; Lin et al, 2014 ; Mielck et al, 1999 ; Osborne & Milsom, 1993 ; Steen et al, 1983 ).…”

Section: Introductionmentioning

confidence: 99%

Changes in breathing pattern during severe hypothermia and autoresuscitation from hypothermic respiratory arrest in anesthetized mice

et al. 2021

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Some evidence suggests that both hypothermia and anesthesia can exert similar effects on metabolism and ventilation. This study examined the synergistic effects of anesthesia and hypothermia on ventilation in spontaneously breathing adult mice under three different conditions, that is, (1) pentobarbital group ( n = 7) in which mice were anesthetized with intraperitoneal pentobarbital of 80 mg/kg, (2) sevoflurane‐continued group ( n = 7) in which mice were anesthetized with 1 MAC sevoflurane, and (3) sevoflurane‐discontinued group ( n = 7) in which sevoflurane was discontinued at a body temperature below 22˚C. We cooled mice in each group until breathing ceased and followed this with artificial rewarming while measuring changes in respiratory variables and heart rate. We found that the body temperature at which respiration arrested is much lower in the sevoflurane‐discontinued group (13.8 ± 2.0˚C) than that in the sevoflurane‐continued group (16.7 ± 1.2˚C) and the pentobarbital group (17.0 ± 1.4˚C). Upon rewarming, all animals in all three groups spontaneously recovered from respiratory arrest. There was a considerable difference in breathing patterns between sevoflurane‐anesthetized mice and pentobarbital‐anesthetized mice during progressive hypothermia in terms of changes in tidal volume and respiratory frequency. The changes in the respiratory pattern during rewarming are nearly mirrored images of the changes observed during cooling in all three groups. These observations indicate that adult mice are capable of autoresuscitation from hypothermic respiratory arrest and that anesthesia and hypothermia exert synergistic effects on the occurrence of respiratory arrest while the type of anesthetic affects the breathing pattern that occurs during progressive hypothermia leading to respiratory arrest.

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Metabolic activation of the brachium conjunctivum during induced hypothermia

et al. 1983

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Hypothermia induction and survival in hamsters: The role of temperature acclimation and an anesthetic (halothane)

Cited by 10 publications

References 9 publications

14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation

14C-2-deoxyglucose uptake in the ground squirrel brain during entrance to and arousal from hibernation

Changes in breathing pattern during severe hypothermia and autoresuscitation from hypothermic respiratory arrest in anesthetized mice

Metabolic activation of the brachium conjunctivum during induced hypothermia

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