Hypothermia in multiple sclerosis.

White, K D; Scoones, David; Newman, Peter

doi:10.1136/jnnp.61.4.369

Cited by 47 publications

(43 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thrombocytopenia as seen in patients with hypothermia and multiple sclerosis has been reported in other cases of accidental and spontaneous hypothermia, though we found no such abnormality in our patient [12,13]. Literature supports our belief that rapid rewarming and conservative management is mainly required to manage the hypothermia in such cases [8][9][10][11][12][13] though there are no recommendations available for management of chronic hypothermia or resetting of thermoregulation set point.…”

Section: Discussionsupporting

confidence: 75%

“…Literature supports our belief that rapid rewarming and conservative management is mainly required to manage the hypothermia in such cases [8][9][10][11][12][13] though there are no recommendations available for management of chronic hypothermia or resetting of thermoregulation set point.…”

Section: Discussionmentioning

confidence: 99%

“…They described presence of hypothalamic lesions on autopsy after the death in the same patient, even though no lesions were reported on imaging [12].…”

Section: Discussionmentioning

confidence: 99%

“…White et al also reported an altered lowered thermoregulatory set point in a patient with chronic hypothermia while describing a series of patients of multiple sclerosis with episodic hypothermia [12]. They described presence of hypothalamic lesions on autopsy after the death in the same patient, even though no lesions were reported on imaging [12].…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Spontaneous Periodic Hypothermia with Reduced Basal Temperature in a Patient of Hypoxic Ischemic Encephalopathy Following Surgery for Cervical Spine Injury

Dawar¹,

Chhabra²

2016

JCR

View full text Add to dashboard Cite

Abstract:A 45 years male presented with C5-C6 flexion-distraction injury with quadriplegia (ASIA-A), and after reduction, was operated for anterior stabilization and fusion. Twenty two hours after uneventful surgery, patient sustained hypoxic-ischemic-encephalopathy in an episode of seizure. Following this, he had multiple episodes of hypothermia (92°F) with bradycardia and desaturation, responding well to rewarming measures. Episodes were infrequent initially, subsequently became frequent, with basal readjustment of core temperature to 94°F, following which bradycardia and desaturation settled. Such instance of basal readjustment of core temperature in a cervical injured patient with ischemic brain injury has never been reported.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

“…They described presence of hypothalamic lesions on autopsy after the death in the same patient, even though no lesions were reported on imaging [12].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous Periodic Hypothermia with Reduced Basal Temperature in a Patient of Hypoxic Ischemic Encephalopathy Following Surgery for Cervical Spine Injury

Dawar¹,

Chhabra²

2016

JCR

View full text Add to dashboard Cite

show abstract

“…Although it is difficult to ascertain that a single location among the thermoregulatory pathways can have an effect on the Ztn, it is generally accepted that the POAH exerts such an effect in hibernating and non-hibernating animals based on indirect experimental and clinical evidence [23,24]. In humans, incidental but selective destruction of the hypothalamic region is associated with dysfunctional thermoregulation, as evidenced by passive Tb declines to as low as 29 °C [25][26][27][28][29]. Moreover, exposure of hypothalamically impaired patients to low Tas causes a drop in Tb, whereas the same conditions induce a rectifying rise in Tb in 'control' subjects [28,30], attesting to impaired thermoregulatory capacity in hypothalamically afflicted patients.…”

Section: Thermoregulation Following a Shift In The Thermoneutral Zonementioning

confidence: 99%

The physiology of artificial hibernation

Heger

2015

JCTRes

View full text Add to dashboard Cite

Incomplete understanding of the mechanisms responsible for induction of hibernation prevent translation of natural hibernation to its artificial counterpart. To facilitate this translation, a model was developed that identifies the necessary physiological changes for induction of artificial hibernation. This model encompasses six essential components: metabolism (anabolism and catabolism), body temperature, thermoneutral zone, substrate, ambient temperature, and hibernation-inducing agents. The individual components are interrelated and collectively govern the induction and sustenance of a hypometabolic state. To illustrate the potential validity of this model, various pharmacological agents (hibernation induction trigger, delta-opioid, hydrogen sulfide, 5'-adenosine monophosphate, thyronamine, 2-deoxyglucose, magnesium) are described in terms of their influence on specific components of the model and corollary effects on metabolism. Relevance for patients: The ultimate purpose of this model is to help expand the paradigm regarding the mechanisms of hibernation from a physiological perspective and to assist in translating this natural phenomenon to the clinical setting.

show abstract

Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

Kamp

Paschali

Bouanane

et al. 2021

Human Psychopharmacology

View full text Add to dashboard Cite

Objective Hypothermia is a potentially lethal adverse reaction to typical and atypical antipsychotic drugs (APD). Among predisposing factors are advanced age and comorbid somatic diseases. The aim of this study was to assess the incidence of hypothermia and quantify risk factors. Method Charts of N = 3002 psychogeriatric inpatients were screened for incidence of hypothermia (body core temperature <35.0°C). The frequency of hypothermia was compared between patients treated with versus without APD and, within the sample of APD‐treated patients, for (1) specific APD, (2) sex, (3) main diagnosis, and (4) age. Results N = 54 cases (2.6%) of hypothermia occurred in APD‐treated patients and 12 cases (1.3%) in non‐APD‐treated patients (p = 0.024). In APD‐treated patients, only male sex (p = 0.038) and pipamperone were associated with a higher incidence of hypothermia (p = 0.0017). Whereas the main diagnosis delirium showed a trend to significance, age did not correlate with hypothermia. Conclusion Medication with pipamperone was associated with an increased risk of hypothermia. The advanced age of our sample might as well explain the high incidence of hypothermia within our sample and the failure to detect high age as a risk factor due to a ceiling effect.

show abstract

Hypothermia in multiple sclerosis.

Cited by 47 publications

References 39 publications

Spontaneous Periodic Hypothermia with Reduced Basal Temperature in a Patient of Hypoxic Ischemic Encephalopathy Following Surgery for Cervical Spine Injury

Spontaneous Periodic Hypothermia with Reduced Basal Temperature in a Patient of Hypoxic Ischemic Encephalopathy Following Surgery for Cervical Spine Injury

The physiology of artificial hibernation

Characteristics of antipsychotic drug‐induced hypothermia in psychogeriatric inpatients

Contact Info

Product

Resources

About