Hypothermia and feeding induced simultaneously in rats by perfusion of neuropeptide Y in preoptic area

Roscoe, Amy K.; Myers, R.D.

doi:10.1016/0091-3057(91)90066-b

Cited by 34 publications

(8 citation statements)

References 32 publications

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“…This type of feeding behavior mimics some syndromes of human obesity and may provide a chemical basis for overeating. In addition to induction of hyperphagia, central NPY infusion also results in suppressed metabolic rate, hypothermia, bradycardia, and hypotension [Billington et al, 1991;Roscoe and Myers, 1991;Stanley et al, 1986]. Peripherally, NPY acts as a powerful pressor agent to produce sustained, dose-dependent increases in mean arterial blood pressure along with concurrent increases in systemic vascular resistance [Hashim et al, 1997;Shine et al, 1994].…”

Section: Discussionmentioning

confidence: 98%

“…Intracerebroventricular infusion of NPY into the brains of rats results in insatiable eating and ultimate weight gain [Beck et al, 1992;Morley, 1987;Paez and Myers, 1991;Stanley et al, 1986Stanley et al, , 1989. This weight gain cannot be wholly accounted for by increasing feeding, suggesting that NPY also acts in a negative manner on energy metabolism [Billington et al, 1991;Roscoe and Myers, 1991;Stanley et al, 1986]. Of several NPY receptors, selective NPY Y1 receptor (NPY1R) agonists have been shown to elicit feeding behavior when injected into the brain [Kanatani et al, 1996;Leibowitz, 1991].…”

Section: Introductionmentioning

confidence: 98%

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Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas

1999

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas

1999

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“…After NE HCI was dissolved in an acidified pyrogen-free artificial CSF (Myers, 1977), 1.0 pg NE was injected at incremental depths in a volume of 1.0 pl below the guide tube . As established previously as a standard to denote a feeding and/or temperature responsive site in the hypothalamus Roscoe and Myers, 1991;Mifiano and Myers, 1991), a cumulative intake of 1 5.0 g of food or a fall in T, of 2 0.5"C or both within 0.5 hr after the micro-injection served to specify that a given site was reactive to the catecholamine. Thereafter, a micro-injection was given only at those anatomical loci at which a positive response to NE was evoked.…”

Section: Micro-injection Proceduresmentioning

confidence: 99%

Fever and feeding in the rat: Actions of intrahypothalamic interleukin‐6 compared to macrophage inflammatory protein‐1β (MIP‐1β)

Myers

Lopez-Valpuesta

Minñano

et al. 1994

J of Neuroscience Research

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The chemokines, macrophage inflammatory protein-1 (MIP-1) and its subunit MIP-1 beta, induce an intense fever in the rat when they are injected directly into the anterior hypothalamic, pre-optic area (AH/POA), a region containing thermosensitive neurons. The purpose of this study was to compare the central action on body temperature (Tb) of MIP-1 beta with that of interleukin-6 (IL-6), which also has been implicated in the cerebral mechanism underlying the pathogenesis of fever. Following the stereotaxic implantation in the AH/POA of guide cannulae for repeated micro-injections, radio transmitters which monitor Tb continuously were inserted intraperitoneally in each of 15 male Sprague-Dawley rats. Each micro-injection was made in a site in the AH/POA in a volume of 1.0 microliter of pyrogen-free artificial CSF, recombinant murine MIP-1 beta, or recombinant human IL-6. MIP-1 beta in a dose of 25 pg evoked an intense fever characterized by a short latency, a mean maximum rise in Tb of 2.4 +/- 0.21 degrees C reached by 3.7 +/- 0.42 hr, and a duration exceeding 6.5 hr. Injected into homologous sites in the AH/POA, IL-6 induced a dose dependent fever of similar latency and a mean maximal increase in Tb of 1.2 +/- 0.25 degrees C, 1.8 +/- 0.15 degrees C, and 2.1 +/- 0.22 degrees C and duration of 6.2 +/- 1.28 hr, 6.7 +/- 0.49 hr, and 6.8 +/- 0.65 hr when given in doses of 25, 50, and 100 ng, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The weight gain in rats with NPY-induced obesity is greater than would be expected from the increased energy consumption alone [50] and recent studies have confirmed directly that NPY injected into the hypothalamus decreases energy expenditure [62] and can even induce hypothermia [54]. NPY probably acts in the PVN and other sites to inhibit the sympathetic activation of thermogenesis in BAT [63], thus simulating the 'autonomic imbalance' proposed to account for the thermogenic defect in genetically obese rodents [5,6].…”

Section: Does Npy Affect Energy Balance?mentioning

confidence: 99%

Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?

Dryden

Frankish

Wang

et al. 1994

Eur J Clin Investigation

123

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Abstract. Obesity is a vast and ever-expanding problem in affluent societies, which we have so far failed to confront. Over 20% of Western European and North American adults are overweight to a degree which may potentially shorten their life expectancy. Obesity has well-known associations with non-insulin-dependent diabetes (NIDDM), hypertension, dyslipidaemia and coronary heart disease, as well as less obvious links with diseases such as osteoarthrosis and various malignancies; it also causes considerable problems through reduced mobility and decreased quality of life. The overall financial burden of obesity is impossible to calculate precisely, but may account for 6-8% of total health-care expenditure in North America [ 13 (similar estimates probably apply to Western Europe).Obesity is difficult to treat and many patients remain obstinately overweight despite our best efforts. The available options range from behavioural therapy to gastrointestinal surgery and include numerous drugs designed to suppress appetite or increase energy expenditure. As in many other areas of medicine, the length and diversity of this list are reliable signs that effective treatment is still beyond our reach.This article argues that new anti-obesity drugs may emerge from recent advances in understanding the control of energy balance in rodents. The discussion is structured around neuropeptide Y (NPY), a major brain peptide which at present appears to be important in regulating energy balance and seems a promising candidate for therapeutic exploitation.

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Hypothermia and feeding induced simultaneously in rats by perfusion of neuropeptide Y in preoptic area

Cited by 34 publications

References 32 publications

Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas

Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas

Fever and feeding in the rat: Actions of intrahypothalamic interleukin‐6 compared to macrophage inflammatory protein‐1β (MIP‐1β)

Neuropeptide Y and energy balance: one way ahead for the treatment of obesity?

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