Hypothalamopituitary hyperactivity and endometrial carcinoma

Peculiarities of hyperlipidaemia in tumour patients

“…Besides, the VLDL and LDL levels rise in the course of normal ageing (see Table I) as a result of the primary hypothalamic shifts. This point is discussed in detail in Dilman (1968Dilman ( , 1979Dilman ( , 1980 and Dilman et al (1979). It should be stressed that from this point of view only the levels of lipids and other metabolites characteristic for the ages of 20-25 years, when cancer incidence is lowest, may be considered as normal, so even when there is no difference in blood lipids between cancer patients and age-matched controls, the patients should be regarded as hyperlipidaemic compared with healthy persons aged 20-25 (Dilman, 1979(Dilman, , 1980 (Dilman, , 1978a.…”

“…In contrast to studies of hypercholesterolaemia in cancer patients (e.g. Dilman & Bobrov, 1966;Feldman & Carter, 1971;Smethurst et al, 1975) (Dilman & Bobrov, 1966;Dilman et al, 1968;Tsyrlina et al, 1977;Berstein et al, 1978 (King, 1947), triglycerides were estimated according to the method of Carlson (1963), total :-lipoproteins (VLDL+ LDL) according to that of Ledvina & Coufalova (1960) and HDL-cholesterol was measured after removal of VLDL and LDL from the serum by precipitation wAith heparin and manganese chloride (Burstein & Scholnick, 1973). Threshold values of lipid concentrations for typing hyperlipoproteinaenmia wNere chosen according to the recommendations of Carlson et al (1977).…”

“…On the one hand, these disturbances may be the result of intensified transport of lipids and carbohydrates to the tumour caused by the influence of the tumour itself (Begg, 1958;Kavetsky, 1962;Shapot, 1975). Although this mechanism may well operate, especially in the later stages of tumour progression, a number of data and considerations point to other possible reasons for disturbances of lipid metabolism, such as nonspecific changes in the energy homoeostat which are not dependent upon the presence of a tumour and occur in the course of normal ageing, especially in some age-related diseases (Dilman, 1968(Dilman, , 1978a(Dilman, , 1979Dilman et al, 1979). These changes may be risk-factors for tumour diseases and may be controllable.…”