Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure

Moura, Rodrigo Ferreira de; Nascimento, Lucas F.; Ignácio-Souza, Letícia Martins; Morari, Joseane; Razolli, Daniela S.; Solon, Carina; Souza, Gabriela Freitas Pereira de; Festuccia, William T.; Velloso, Lı́cio A.

doi:10.1038/ijo.2015.188

Cited by 20 publications

(16 citation statements)

References 46 publications

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“…In addition, the molecular localization of JAZF1 signaling by MBH Ad‐ JAZF1 is another important issue of concern. Similar to previous reports, 58‐60 we demonstrated that the injection of Ad‐ GFP into the MBH resulted in an effect that was anatomically restricted to the hypothalamic region related to energy balance. It should also be noted that in addition to the association between the liver and the brain, changes in food intake, BW, and other metabolic tissues (eg, fat and muscle) can also alter the degree of insulin sensitivity in the entire body and liver.…”

Section: Discussionsupporting

confidence: 90%

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Zhou

Wang

et al. 2020

FASEB j.

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The role of central juxtaposed with another zinc finger gene 1 (JAZF1) in glucose regulation remains unclear. Here, we activated mediobasal hypothalamus (MBH) JAZF1 in high-fat diet (HFD)-fed rats by an adenovirus expressing JAZF1 (Ad-JAZF1). We evaluated the changes in the hypothalamic insulin receptor (InsR)-PI3K-Akt-AMPK pathway and hepatic glucose production (HGP). To investigate the impact of MBH Ad-JAZF1 on HGP, we activated MBH JAZF1 in the presence or absence of ATPdependent potassium (K ATP ) channel inhibition, hepatic branch vagotomy (HVG), or an AMPK activator (AICAR). In HFD-fed rats, MBH Ad-JAZF1 decreased body weight and food intake, and inhibited HGP by increasing hepatic insulin signaling. Under insulin stimulation, MBH Ad-JAZF1 increased InsR and Akt phosphorylation, and phosphatidylinositol 3, 4, 5-trisphosphate (PIP3) formation; however, AMPK phosphorylation was decreased in the hypothalamus. The positive effect of MBH JAZF1 on hepatic insulin signaling and HGP was prevented by treatment with | 7059 ZHOU et al.

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Section: Discussionsupporting

confidence: 90%

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Zhou

Wang

et al. 2020

FASEB j.

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“…Scd2 is a crucial enzyme in the synthesis of monounsaturated fatty acids which are required for maintaining a normal epidermal permeability barrier function, and are components of triglycerides (Miyazaki et al, 2005). Alterations in Scd2 levels may affect lipid content in non-hepatic organs (de Moura et al, 2016) where level and type of lipid is critical to function. Elovl-6 is one of six mammalian enzymes responsible for fatty acid elongation beyond 16 carbons to produce very long chain fatty acids.…”

Section: Discussionmentioning

confidence: 99%

Tetrabromobisphenol A activates the hepatic interferon pathway in rats

et al. 2017

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Tetrabromobisphenol A (TBBPA) is a widely used flame retardant in printed circuit boards, paper, and textiles. In a two-year study, TBBPA showed evidence of uterine tumors in female Wistar-Han rats and liver and colon tumors in B6C3F1 mice. In order to gain further insight into early gene and pathway changes leading to cancer, we exposed female Wistar Han rats to TBBPA at 0, 25, 250, or 1000 mg/kg (oral gavage in corn oil, 5×/week) for 13 weeks. Because at the end of the TBBPA exposure period, there were no treatment-related effects on body weights, liver or uterus lesions, and liver and uterine organ weights were within 10% of controls, only the high dose animals were analyzed. Analysis of the hepatic and uterine transcriptomes showed TBBPA-induced changes primarily in the liver (1000 mg/kg), with 159 transcripts corresponding to 132 genes differentially expressed compared to controls (FDR = 0.05). Pathway analysis showed activation of interferon (IFN) and metabolic networks. TBBPA induced few molecular changes in the uterus. Activation of the interferon pathway in the liver occurred after 13-weeks of TBBPA exposure, and with longer term TBBPA exposure this may lead to immunomodulatory changes that contribute to carcinogenic processes.

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“…The control group (MO) average on each treatment day (day 2, 4 or 10) was used to calibrate all groups. PCR efficiency was calculated prior to the experiments, and the 2^-DDCT method was used to calculate gene expression [20].…”

Section: Methodsmentioning

confidence: 99%

Topical essential fatty acid oil on wounds: Local and systemic effects

et al. 2019

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BackgroundThe use of medicinal plants and their derivatives is increasing, and approximately one-third of all traditional herbal medicines are intended for wound treatment. Natural products used in these treatments include vegetable oils, which are rich in essential fatty acids. Once in contact with an ulcerative surface, the oil reaches the blood and lymphatic vessels, thus eliciting systemic effects.ObjectiveThis study evaluated the local and possible systemic effects of essential fatty acids (sunflower oil) applied topically to rat wounds.MethodsCutaneous punch wounds (6 mm) were produced on the dorsa of 30 rats. Saline (SS), mineral oil (MO) or essential fatty acid (EFA) solutions were applied topically. Healing was evaluated after 2, 4 and 10 days (n = 5 per group) by visual and histological/morphometric examination, second harmonic generation (SHG) microscopy, and cytokine and growth factor quantification in the scar tissue (real-time PCR) and in serum (ELISA).ResultsMO/EFA-treated animals had higher IGF-1, leptin, IL-6 and IFN-γ mRNA expression and lower serum IL-6 levels than the control (SS/MO) animals. SHG analysis showed no difference in collagen density between the animals treated with MO and EFA.ConclusionEFA treatment induces topical (observed by local IGF-1, leptin, IL-6 and IFN-γ production) and systemic effects, lowering IL-6 levels in the serum. As the oil is widely used to shorten ulcer healing time, studies are needed to evaluate the treatment safety and possible undesired effects.

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Hypothalamic stearoyl-CoA desaturase-2 (SCD2) controls whole-body energy expenditure

Abstract: Thus, SCD2 is highly expressed in the hypothalami of rodents and its knockdown reduces body mass due to increased whole-body energy expenditure.

Cited by 20 publications

References 46 publications

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Effect of central JAZF1 on glucose production is regulated by the PI3K‐Akt‐AMPK pathway

Tetrabromobisphenol A activates the hepatic interferon pathway in rats

Topical essential fatty acid oil on wounds: Local and systemic effects

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