Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet

Segarra, Ana Belén; Domínguez-Vías, Germán; Redondo, Jose Luis; Martı́nez-Cañamero, Magdalena; Ramírez-Sánchez, Manuel; Prieto, Isabel

doi:10.3390/nu13020480

Cited by 6 publications

(13 citation statements)

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“…As indicated previously, the source of fat in the diet has demonstrated to be decisive in the development of metabolic syndrome, obesity and hypertension [62][63][64]. Changes in systemic and local RAS play an important role in this process [4,5,15,65,66]. The increase in the blood pressure values results in an increase of the renal artery pressure, triggering a high rate of filtration and increasing the delivery of sodium and water to the distal nephron, where the macula densa is located [67].…”

Section: Discussionmentioning

confidence: 99%

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Domínguez-Vías

Segarra

Ramírez-Sánchez

et al. 2021

IJMS

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High saturated fat diets have been associated with the development of obesity and hypertension, along with other pathologies related to the metabolic syndrome. In contrast, the Mediterranean diet, characterized by its high content of monounsaturated fatty acids, has been proposed as a dietary factor capable of positively regulating cardiovascular function. These effects have been linked to changes in the local renal renin angiotensin system (RAS) and the activity of the sympathetic nervous system. The main goal of this study was to analyze the role of two dietary fat sources on aminopeptidases activities involved in local kidney RAS. Male Wistar rats (six months old) were fed during 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or the standard diet enriched with butter (20%) plus cholesterol (0.1%) (Bch). Kidney samples were separated in medulla and cortex for aminopeptidase activities (AP) assay. Urine samples were collected for routine analysis by chemical tests. Aminopeptidase activities were determined by fluorometric methods in soluble (sol) and membrane-bound (mb) fractions of renal tissue, using arylamide derivatives as substrates. After the experimental period, the systolic blood pressure (SBP) values were similar in standard and VOO animals, and significantly lower than in the Bch group. At the same time, a significant increase in GluAP and IRAP activities were found in renal medulla of Bch animals. However, in VOO group the increase of GluAP activity in renal medulla was lower, while AspAP activity decreased in the renal cortex. Furthermore, the VOO diet also affected other aminopeptidase activities, such as TyrAP and pGluAP, related to the regulation of the sympathetic nervous system and the metabolic rate. These results support the beneficial effect of VOO in the regulation of SBP through changes in local AP activities of the kidney.

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Section: Discussionmentioning

confidence: 99%

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Domínguez-Vías

Segarra

Ramírez-Sánchez

et al. 2021

IJMS

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“…In turn, it was observed in the ventricle that CysAP (mb) activity was significantly elevated with diet S in addition to VOO. These data may have repercussions with previously published data, where they identified that the local and serum mRNA and/or the activities of AspAP and GluAP progressively increase with the degree of saturation of fatty acids in the diet [ 4 , 7 , 10 , 72 ]. GluAP activity is modified by the composition of fatty acids in the diet and by the cholesterol content [ 4 , 5 , 6 , 9 , 57 ], directly or indirectly, and with an important role in the development of cardiovascular disorders and the pathophysiology of hypertension.…”

Section: Discussionmentioning

confidence: 61%

“…[4,7,9]. Elevated plasma cholesterol levels are another important risk factor widely recognized for its relationship with angiotensin metabolism [4,5,7,10,12,72], with Mediterranean countries showing lower rates of heart disease than other countries due to the usual diet rich in olive oil [75].…”

Section: Discussionmentioning

confidence: 99%

“…HFDs alter the baroreceptor reflex [ 76 ], and the type of fatty acid that makes up the diet is capable of modulating the central [ 10 , 26 , 77 ] and local RAS regulatory APs [ 4 , 5 , 7 , 9 , 57 ]. Our results show that the VOO diet favored the stabilization of the RAS with respect to the Bch diet, by lowering the values of GluAP (mb) activities in the aorta, ArgAP (mb) in the ventricle and aorta, and CysAP (mb) in the atrium.…”

Section: Discussionmentioning

confidence: 99%

“…The reduction in SAFA in substitution by MUFA attenuates the increase in blood pressure (BP) [4]. These alterations, depending on the degree of fatty acid saturation, are related to changes in the systemic or local renin-angiotensin systems (RAS) [5][6][7][8][9][10]. The activation of the RAS participates in the development of MetS, heart failure [11], and pathophysiology of hypertension [4,7,[12][13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats

et al. 2021

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(1) Background: The replacement of diets high in saturated fat (SAFA) with monounsaturated fatty acids (MUFA) is associated with better cardiovascular function and is related to the modulation of the activity of the local renin–angiotensin system (RAS) and the collagenase activity of dipeptidyl peptidase IV (DPP-IV). The objective of the work was to verify the capacity of different types of dietary fat on the regulatory activities of RAS and DPP-IV. (2) Methods: Male Wistar rats were fed for 24 weeks with three different diets: the standard diet (S), the standard diet supplemented with virgin olive oil (20%) (VOO), or with butter (20%) plus cholesterol (0.1%) (Bch). The proteolytic activities were determined by fluorometric methods in the soluble (sol) and membrane-bound (mb) fractions of the left ventricle and atrium, aorta, and plasma samples. (3) Results: With the VOO diet, angiotensinase values were significantly lower than with the Bch diet in the aorta (GluAP and ArgAP (mb)), ventricle (ArgAP (mb)) and atrium (CysAP (sol)). Significant decreases in DPP-IV (mb) activity occurred with the Bch diet in the atrium and aorta. The VOO diet significantly reduced the activity of the cardiac damage marker LeuAP (mb) in the ventricle and aorta, except for LeuAP (sol) in the ventricle, which was reduced with the Bch diet. (4) Conclusions: The introduction into the diet of a source rich in MUFA would have a beneficial cardiovascular effect on RAS homeostasis and cardiovascular functional stability.

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Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome

Guimarães

Marinho

Motta‐Santos

et al. 2023

The Journal of Nutritional Biochemistry

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Hypothalamic Renin–Angiotensin System and Lipid Metabolism: Effects of Virgin Olive Oil versus Butter in the Diet

Cited by 6 publications

References 58 publications

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

Effects of Virgin Olive Oil on Blood Pressure and Renal Aminopeptidase Activities in Male Wistar Rats

High-Fat Diets Modify the Proteolytic Activities of Dipeptidyl-Peptidase IV and the Regulatory Enzymes of the Renin–Angiotensin System in Cardiovascular Tissues of Adult Wistar Rats

Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome

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