Hypothalamic Regulatory Mechanisms of Aging

Influences of intrahypothalamic administration of microrna inhibitors and mimetics on blood plasma biomarkers with aging of the rat

“…Обнаружено, что в медиальной группе ядер гипоталамуса с возрастом изменяется экспрессия кальций-связывающих белков, NO синтазы, а также снижается частота импульсации нейронов [4][5][6]. При этом важная роль в регуляции старения отводится дорсомедиальному ядру гипоталамуса (ДМЯ), которое принимает участие в контроле метаболизма и, наряду с супрахиазмальным ядром, в регуляции ритмической деятельности [1,7]. В осуществлении этих процессов доказано участие экзосомальных ми-кроРНК [8].…”

The Role of Systemic Filtrating Organs in Aging and Their Potential in Rejuvenation Strategies

“…However, given that this particular topic has not been explored so far, and in the absence of any direct findings on the possible involvement of the kidney in aging, this presents a major challenge or a limitation in the present review, as this hypothesis hinges on the amazing results presented by Mehdipour et al, (2020), where replacement of plasma with a mixture of saline and albumin was sufficient to produce the same rejuvenation effects observed in heterochronic parabiosis. Additionally, the role of the central nervous system, and in particular the effect of hypothalamus aging on energy homeostasis, hormone balance, circadian rhythm, nutrient sensing dysfunction, stem cell exhaustion, loss of proteostasis, and epigenetic alterations was not discussed [157,158], focusing more on major pathways of rejuvenation studies instead. Thus, it is obvious that several studies are necessary to elucidate the exact role of filtration on aging, but it is our belief that such an approach is indeed warranted and merits further exploration.…”

Changes of Signaling Pathways in Hypothalamic Neurons with Aging

“…According to this theory, age-related raising of the hypothalamus threshold for homeostatic signals leads to aging and the appearance of age-related disease in different species [3,4]. The advancement of new research techniques, including cutting-edge approaches in genetics, molecular biology, and neuroscience, allowed the study of the role of the hypothalamus in aging mechanisms in more detail [5][6][7]. In recent years, it has been suggested that the age-related loss of hypothalamic stem cells plays a major role in the development of hypothalamic neuroinflammation and mammalian aging [8,9].…”