Hypothalamic pituitary gonadal axis dysregulation in depressed women

Meller, William H.; Grambsch, Patricia M.; Bingham, C. Raymond; Tagatz, George E.

doi:10.1016/s0306-4530(00)00050-0

Cited by 38 publications

(19 citation statements)

References 12 publications

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“…This might reflect a dysregulation of the hypothalamo-pituitarygonadal axis in these animals, as described in depressed women (Meller et al, 2001;Young et al, 2000). However, no problems in breeding have been observed in H mice (El Yacoubi et al, 2003).…”

Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselimentioning

confidence: 73%

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Popa

Yacoubi²,

Vaugeois³

et al. 2005

Neuropsychopharmacol

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In depressed patients, sleep undergoes marked alterations, especially sleep onset insomnia, sleep fragmentation, and disturbances of the Rapid Eye Movement (REM) sleep. Abnormalities of rest-activity rhythms and of hypothalamic-pituitary-adrenocortical function have also been described in these patients. In the present study, we examined the presence of such abnormalities in a recently developed line of mice (Helpless mice-H) that exhibit depression-like behaviors in validated tests, compared to the nonhelpless (NH) line derived from the same colony. Experiments were essentially carried out in females for which previous studies showed marked differences between H and NH lines. Compared to NH mice, the H line exhibited (i) lower basal locomotor activity, (ii) sleep fragmentation, shift towards lighter sleep stages, and facilitation of REM sleep reflected by increased amounts and decreased latency, (iii) larger response to the REM sleep promoting effect of muscarinic receptor stimulation (by arecoline). In contrast, H and NH mice were equally responsive to the REM sleep inhibitory effect of 5-HT 1A receptor stimulation (by 8-OH-DPAT). In addition, a deficiency in delta power enhancement after sleep deprivation was observed in the H group, and acute immobilization stress in this group failed to elicit a REM sleep rebound and was associated with a long-lasting raise in serum corticosterone levels. These results further validate H mice as a depression model and suggest they might be of particular interest for investigating the neurobiological mechanisms and possibly genetic substrates underlying sleep alterations associated with depression.

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Section: Locomotor Activity and Sleep-wakefulness Cycles Under Baselimentioning

confidence: 73%

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Popa

Yacoubi²,

Vaugeois³

et al. 2005

Neuropsychopharmacol

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“…Depressed women have been found to have reduced E2 (Schuschke et al, 2000). The hypothalamic-pituitary-gonadal (HPG) axis regulates the development and function of the gonads and in depressed patients this axis was found to be diminished (Baischer et al, 1995;Meller et al, 2001). Correspondingly, depression rates increase in women who are undergoing menopause (Freeman, 2010;Harsh et al, 2009).…”

Section: Introductionmentioning

confidence: 94%

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

Pang

et al. 2015

Experimental Neurology

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“…Depressed women showed a decrease in frequency and a lack of rhythm in the LH pulses which points to a relationship between LH and mood (Meller et al, 2001). …”

Section: Introductionmentioning

confidence: 99%

Comparison of affect changes during the ovulatory phase in women with and without hormonal contraceptives

Rebollar

Balaña

Pastor

2017

Heliyon

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Studies about affect changes during the menstrual cycle and the role of hormones in these changes have yielded contradictory results. Often research has focused on the pre-menstrual phase, with few studies paying specific attention to the affect changes around ovulation. In this research thirty women completed a daily questionnaire measuring the positive and negative affect during their menstrual cycle. These women were divided in two groups: hormonally-contracepting and naturally-cycling. The Positive and Negative Affect Schedule was used to measure the affect. A Digital Ovulation Test was used to determine the day of ovulation in the participants not taking hormonal contraceptives by measuring the Luteinizing Hormone peak. The differences in positive affect (PA) and negative affect (NA) between groups were examined. The results indicate that during the ovulatory phase, PA scores are significantly higher in naturally-cycling women than hormonally-contracepting women.

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Hypothalamic pituitary gonadal axis dysregulation in depressed women

Cited by 38 publications

References 12 publications

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

Homeostatic Regulation of Sleep in a Genetic Model of Depression in the Mouse: Effects of Muscarinic and 5-HT1A Receptor Activation

The influence of the HPG axis on stress response and depressive-like behaviour in a transgenic mouse model of Huntington's disease

Comparison of affect changes during the ovulatory phase in women with and without hormonal contraceptives

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