Hypothalamic-pituitary-adrenal axis measures and cognitive abilities in early psychosis: Are there sex differences?

Labad, Javier; Gutiérrez-Zotes, Alfonso; Creus, Marta; Montalvo, Itziar; Cabezas, Ángel; Solé, Montse; Ortega, Laura; Algora, Maria José; Vilella, Elisabet

doi:10.1016/j.psyneuen.2016.06.006

Cited by 19 publications

(20 citation statements)

References 50 publications

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“…In the domain of executive function, COR predicted poor performance on the cognitive functioning in male schizophrenics (26). On the other hand, Labad J et al (27) suggest that there are sex differences in the relationship between HPAA measures and cognitive abilities in early psychosis. So, there are different interpretations of HPAA by gender due to first episode or recurrent schizophrenia.…”

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confidence: 98%

Functional Status of Hypothalamic–Pituitary–Thyroid and Hypothalamic–Pituitary–Adrenal Axes in Hospitalized Schizophrenics in Shanghai

Zhu

Tao

et al. 2020

Front. Psychiatry

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Objective: Neuroendocrine dysfunction is related to the pathogenesis of mental disorders, but conclusions from clinical research lack consistency. We aimed to investigate the neuroendocrinal pathophysiology and its correlation with clinical symptoms in patients with schizophrenia. Methods:The present cross-sectional study included 486 inpatients with schizophrenia admitted at a psychiatric hospital in Shanghai within one year, and 154 healthy controls (HC) matched on age and gender. The serum hemoconcentrations of thyroid-stimulating hormone (TSH), total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), free thyroxine (FT4), adrenocorticotrophic hormone (ACTH), and cortisol (COR) were measured via electrochemical luminescence immunoassay. Pathophysiological conversions of neuroendocrine were then associated with gender, age, age at onset, antipsychotic treatment using hierarchical multiple linear regression.Results: When compared to HC, the schizophrenia group showed elevated ACTH and COR levels and decreased TT3 and TT4 levels (p's < 0.05). First-episode patients showed lower TSH and higher FT3 and FT4 (p's < 0.05) compared to recurrent patients. Female patients showed higher TSH and lower TT3, FT3, and ACTH levels (p's < 0.05) compared to males. We observed the area under the curve (AUC) of the predictive model to distinguish between schizophrenia and HC to be 0.737 among total samples and between first-episode and recurrent schizophrenia to be 0.890 among subgroups.Conclusions: Decreased TT3 and TT4 and elevated ACTH and COR levels appear to be associated with schizophrenia symptoms. The chronic recurrent trait of schizophrenia Frontiers in Psychiatry | www.frontiersin.org

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confidence: 98%

Functional Status of Hypothalamic–Pituitary–Thyroid and Hypothalamic–Pituitary–Adrenal Axes in Hospitalized Schizophrenics in Shanghai

Zhu

Tao

et al. 2020

Front. Psychiatry

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“…Similar inconsistency has occurred in studies of CAR associations with overall cognitive performance (e.g. Aas et al, 2011;Evans et al, 2011;Labad et al, 2016).…”

Section: Introductionmentioning

confidence: 57%

The cortisol awakening response predicts a same-day index of executive function in healthy young adults

Law

Evans

Thorn

et al. 2020

International Journal of Psychophysiology

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The cortisol awakening response (CAR) is associated with various aspects of cognition, including executive function, in older adult and clinical samples. However, the association between these variables in the healthy functioning population is not well understood due to the limited number of appropriately controlled studies. This study explored the association between the CAR and a set shifting index of executive function in 55 (44 females) healthy participants aged 20.2±3.0 years. Notoriously, assessment of the CAR from self-collected saliva samples within the domestic setting is subject to sample timing error, so electronic monitoring of both awakening and sampling times were employed. Participants attended the laboratory in the afternoon of CAR assessment for testing on the Attention Switching Task of the CANTAB neuropsychological testing battery. A positive association was found between CAR magnitude and attention-switching performance in the afternoon of the same day. This was independent of known relevant CAR covariates, but only evident in CAR data collected without delay exceeding 8 min post-awakening. These findings offer insight into a potential role for the CAR in modulating cognitive functions associated with the pre-frontal cortex.

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“…Another limitation of our study was measuring the CAR only one day. As the original protocol also included the assessment of the dexamethasone suppression test [ 44 , 45 , 46 ], all participants took 0.25 mg of dexamethasone at 11 p.m. and therefore we dismissed the possibility of collecting further CAR sampling the next day. In the calculation of the CAR, we used the AUC with respect to the increase, as previous guidelines recommend using measures of change in cortisol levels that capture the dynamic of post-awakening cortisol changes (e.g., AUC i ).…”

Section: Discussionmentioning

confidence: 99%

“…The exclusion criteria were as follows: age less than 18 years, a diagnosis of psychiatric disorders including substance abuse or dependence (except nicotine), intellectual disability, neurological disorders, severe medical conditions, pregnancy or puerperium, receiving current psychopharmacological treatment (including benzodiazepines), and therapy with corticoids or contraceptive pill use in the previous three months. All participants were recruited in two provinces from Catalonia, Spain (Barcelona and Tarragona) and participated as healthy control groups in other studies exploring the role of the HPA axis on cognition in patients with major depression [ 44 ], obsessive-compulsive disorder [ 45 ] or psychotic disorders [ 46 ]. All healthy participants were recruited by consecutive sampling from the community by advertisements.…”

Section: Methodsmentioning

confidence: 99%

The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals

Labad

Salvat‐Pujol

Armario

et al. 2020

IJERPH

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Sleep plays a crucial role in cognitive processes. Sleep and wake memory consolidation seem to be regulated by glucocorticoids, pointing out the potential role of the hypothalamic-pituitary-adrenal (HPA) axis in the relationship between sleep quality and cognitive abilities. Trait anxiety is another factor that is likely to moderate the relationship between sleep and cognition, because poorer sleep quality and subtle HPA axis abnormalities have been reported in people with high trait anxiety. The current study aimed to explore whether HPA axis activity or trait anxiety moderate the relationship between sleep quality and cognitive abilities in healthy individuals. We studied 203 healthy individuals. We measured verbal and visual memory, working memory, processing speed, attention and executive function. Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Trait anxiety was assessed with the State-Trait Anxiety Inventory. HPA axis measures included the cortisol awakening response (CAR), diurnal cortisol slope and cortisol levels during the day. Multiple linear regression analyses explored the relationship between sleep quality and cognition and tested potential moderating effects by HPA axis measures and trait anxiety. Poor sleep quality was associated with poorer performance in memory, processing speed and executive function tasks. In people with poorer sleep quality, a blunted CAR was associated with poorer verbal and visual memory and executive functions, and higher cortisol levels during the day were associated with poorer processing speed. Trait anxiety was a moderator of visual memory and executive functioning. These results suggest that subtle abnormalities in the HPA axis and higher trait anxiety contribute to the relationship between lower sleep quality and poorer cognitive functioning in healthy individuals.

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Hypothalamic-pituitary-adrenal axis measures and cognitive abilities in early psychosis: Are there sex differences?

Cited by 19 publications

References 50 publications

Functional Status of Hypothalamic–Pituitary–Thyroid and Hypothalamic–Pituitary–Adrenal Axes in Hospitalized Schizophrenics in Shanghai

Functional Status of Hypothalamic–Pituitary–Thyroid and Hypothalamic–Pituitary–Adrenal Axes in Hospitalized Schizophrenics in Shanghai

The cortisol awakening response predicts a same-day index of executive function in healthy young adults

The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals

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