Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder

Hadad, Natalie A.; Schwendt, Marek; Knackstedt, Lori A.

doi:10.1080/10253890.2020.1803824

Cited by 12 publications

(8 citation statements)

References 102 publications

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“…It consists of three subscales, herein referred to as IES-R3, which measure intrusion (e.g., intrusive thoughts/feelings/imagery and nightmares: items 1, 2, 3, 6, 9, 14, 16, and 20), avoidance (e.g., avoidance of feelings/situations/ideas: items 5, 7, 8, 11, 12, 13, 17, and 22), and hyperarousal (e.g., anger/irritability and hypervigilance/heightened startle: items 4, 10, 15, 18, 19, and 21) [35]. The six dimension structure of the IES-R, herein referred to as IES-R6, are avoidance (items 5,8,11,17,22), intrusion (items 1, 3, 6, 9, 20), numbing (e.g., numbing of responsiveness: items 7, 12, 13, 14), hyperarousal (e.g., physical reactions and being on guard: items 16, 18, 19, 21), sleep problems/disturbance (e.g., trouble falling staying asleep, items 2, 15), and irritability/dysphoria (e.g., anger and irritability: items 4, 10) [33]. The respondents rate the items of the IES-R on 5-point equal response intervals ranging from 0 (not at all) to 4 (extremely) [35].…”

Section: Methodsmentioning

confidence: 99%

“…However, emotion regulation strategies that involve suppressing rather than modifying trauma-related emotional response may account for the persistence of PTSD symptoms in certain groups due to persistent activation of the hypothalamic-pituitary-adrenal (HPA) axis [3,4]. Stress-susceptibility in PTSD is noted by increased activity of the anterior pituitary glucocorticoid receptor [5]. Parenthetically, cumulative research shows that PTSD is a systemic stress-related mental disorder, which evokes physiological, behavioral, and psychological responses that are conducive to the development of cardiovascular disorders (CVD) [6].…”

Section: Introductionmentioning

confidence: 99%

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Predictive validity of the six-dimension structure of the Impact of Event Scale- Revised for PTSD and related-cardiometabolic consequences (hypertension and obesity) among dental healthcare workers during COVID-19

Ali

Al-Dossary

Aljubilah

et al. 2023

Preprint

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The diagnostic criteria of posttraumatic stress disorder (PTSD) have lately expanded beyond the three common symptoms (intrusion, avoidance, and hyperarousal). Simultaneously, four-, five-, and six-dimensional structures of the Impact of Event Scale-Revised (IES-R), a popular PTSD measure, seem to be more robust than the original three-dimension structure. PTSD and/or specific PTSD symptoms may also evoke adverse cardiometabolic events (e.g., hypertension and obesity) in certain groups. Employing a convenience sample of 58 dental healthcare workers (HCWs) from Russia (mean age = 44.1 ± 12.2 years, 82.8% females), this instrumental study examined the criterion and predictive validity of two IES-R structures: the IES-R3 and the IES-R6 (with added symptoms of numbing, sleep disturbance, and irritability). The subscales of the two IES-R structures expressed good internal consistency, strong correlations with the PTSD Symptom Scale (PSS), hypertension diagnosis, and high body mass index (BMI). In receiver-operating characteristic (ROC) curve analysis, all IES-R models perfectly predicted the PSS (all area under the curve (AUC) values > 0.9, p values < 0.001). The IES-R, both hyperarousal subscales, and the IES-R3 intrusion significantly predicted high BMI. The IES-R did not predict hypertension, but the avoidance subscales and the IES-R3 intrusion significantly predicted it. In conclusion, both IES-R structures can reliably measure PTSD symptoms. The IES-R, hyperarousal, and intrusion may be credible criterion variables for predicting high BMI within PTSD while the intrusion and avoidance subscales may more reliably reflect the cardiovascular consequences of the stress reaction associated with PTSD than the IES-R itself. It is pivotal to verify the results in specific groups (e.g., those with confirmed traumatic exposure and comorbid mood dysfunction). Replication of the study in larger samples, which comprise different physical and metal conditions from heterogenous cultural contexts is necessary.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Predictive validity of the six-dimension structure of the Impact of Event Scale- Revised for PTSD and related-cardiometabolic consequences (hypertension and obesity) among dental healthcare workers during COVID-19

Ali

Al-Dossary

Aljubilah

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The evaluation of comorbid cocaine use disorder and PTSD has garnered valuable insights into the overlapping symptomatology and shared neurobiologic etiology of these comorbid disorders [ 48 , 49 ]. Gawrysiak et al conducted BOLD fMRI scans in 34 treatment-seeking men admitted for cocaine use disorder with and without trauma after 7–10 days of supervised sobriety [ 50 ].…”

Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Hinckley

Danielson

2022

Brain Sciences

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Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress disorder (PTSD) and SUD, and these comorbid disorders exhibit high levels of overlapping symptomatology. Theoretical models proposed to explain the bidirectional relationship between PTSD and SUD include the self-medication hypothesis and susceptibility hypothesis. In this article, we explore neurobiologic changes associated with trauma, PTSD, and SUD that underly dysregulated stress response. Examining lessons learned from recent translational and clinical research, we propose that further elucidating the neurobiologic etiology of comorbid PTSD and SUD will require a collaborative, interdisciplinary approach, including the integration of preclinical and clinical studies, exploration of biologic markers in clinical studies, and accumulation of larger studies and longitudinal studies with the power to study PTSD and SUD. Such research can transform the field and ultimately reduce high rates and costly impairment of co-occurring PTSD and SUD across the lifespan.

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“…The mGluR1 and mGluR5 metabotropic glutamate receptors are also involved in the formation of a hypergluta matergic state in chronic alcohol consumption [80]. The HPA axis has been shown to play a central role in the formation of cocaine addiction [81], in which the dysregulation of glutamatergic signaling is also observed. For example, cocaine self administration and withdrawal in rats evoke changes in structural plasticity in the prelimbic cortex, corresponding to an early hypoglutama tergic state, which is then replaced by a hyperglu tamatergic state.…”

Section: Hyperglutamatergic Conditions In Brain Pathologies and Gluco...mentioning

confidence: 99%

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

Gulyaeva

2022

J Evol Biochem Phys

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Neuroendocrine control mediated by glucocorticoids is important for maintaining the normal functioning of the brain and the balance between the excitation and inhibition systems. Glucocorticoids regulate the state of the brain glutamatergic system both directly, through receptors on glutamatergic synapses, and indirectly. The dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis and its inability to optimally regulate glutamatergic synaptic plasticity leads to the development of neuropsychiatric diseases, while hyperglutamatergic conditions can play a key role in their pathogenesis. Impaired glucocorticoid control of glutamatergic processes underlies cognitive and emotional disorders, epilepsy and a number of other cerebral pathologies, being a common mechanism for the development of many brain diseases and their comorbidities. In this regard, the study of the mechanisms of interaction between the HPA axis and brain glutamatergic system is of priority translational significance.

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Hypothalamic-pituitary-adrenal axis activity in post-traumatic stress disorder and cocaine use disorder

Cited by 12 publications

References 102 publications

Predictive validity of the six-dimension structure of the Impact of Event Scale- Revised for PTSD and related-cardiometabolic consequences (hypertension and obesity) among dental healthcare workers during COVID-19

Predictive validity of the six-dimension structure of the Impact of Event Scale- Revised for PTSD and related-cardiometabolic consequences (hypertension and obesity) among dental healthcare workers during COVID-19

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Neuroendocrine Control of Hyperglutamatergic States in Brain Pathologies: the Effects of Glucocorticoids

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