Hypothalamic Neurohormones Regulating Anterior Pituitary Function

Schally, Andrew V.; Arimura, Akira; Cy, Bowers; Kastin, A. J.; Sawano, Shinji; Tw, Reeding

doi:10.1016/b978-1-4831-9827-9.50016-2

Cited by 115 publications

(118 citation statements)

References 194 publications

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“…Experiments in animals have shown that LH-RH does not release other pituitary hormones [17,19,20,22]. No statistically significant increase in TSH, GH, or cortisol release was found in our human subjects after injection of LH-RH (Table I).…”

Section: Discussionmentioning

confidence: 75%

“…Injection of hypothalamic LH-reduces substances which regulate the release of horleasing hormone (LH-RH) results in stimulation of the mones from the adenohypophysis [19,20,22]. One of release of LH from the pituitary gland of a number of these hypothalamic substances, which controls the reanimals [17,19,20,22]. lease of luteinizing hormone (LH), has been found in Although LH-RH prepared from human hypothal- ami is effective in releasing LH in man [4], all other clinical studies with LH-RH have used a highly purified LH-RH preparation of porcine origin except one [13], in which a crude ovine hypothalamic extract was injected.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

et al. 1972

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ExtractLuteinizing hormone-releasing hormone (LH-RH), purified from porcine hypothalamic tissue, was administered in an intravenous dose of 300 /xg to four prepubertal and four adult human subjects. The resulting increases in plasma levels of LH and FSH were statistically significant (P < 0.01) in the 16-and 32-min samples, but did not differ with the age or sex of the subject groups. The mean maximum increase in plasma LH values was 290% for men and 425% for women. Injection of LH-RH resulted in a 500% mean maximum increase in LH levels in the plasma of boys and 850% in that of girls. The gonadotropin release induced by injection of LH-RH was sufficient to increase plasma levels of estradiol in some individuals. No significant elevation occurred in the levels in plasma of growth hormone, thyrotropin, or cortisol. It is concluded that LH-RH is a potent and specific hypothalamic releasing hormone for LH and FSH in prepubertal children as well as in normal adults. SpeculationThe increases in gonadotropin levels in plasma of all groups seem to reduce the possibility that a change in pituitary responsiveness to LH-RH occurs at puberty. However, similar studies involving larger numbers of individuals tested at varying doses might reveal differences in responses to LH-RH between age or sex groups.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

et al. 1972

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“…This hormone controls the secretion of thyrotropic hormone and prolactin from the anterior pituitary gland (1)(2)(3)(4). Many investigations involving synthesis and bioassay of TRF analogues have been completed in order to determine the structural requirements for activity (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

13C-nuclear magnetic resonance study of [85% 13C-enriched proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of the proline residue.

Haar¹,

Fermandjian²,

Vičar³

et al. 1975

Proc. Natl. Acad. Sci. U.S.A.

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“…The ridence for the existence of growth hormorie releasing factor (GH-RF) in the hypothalamic extracts of animals of different species has been reported during the past decade, and at this time, it has seemed reasonable to conclude that the hypothalamic control of GH secretion, like that of the other pituitary hormones is mediated by a hypophysiotropic releasing factor (Schally et al, 1968;McCann and Poter 1969). …”

mentioning

confidence: 99%

Growth Hormone Releasing Factor Activity in the Stalk-Median Eminence and Plasma Growth Hormone Response to the Ether-Laparotomy Stress in the Rat

Ogawa

1974

Endocrinol Japon

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SynopsisThe present study was performed to aim to the development of the in vitro assay method for growth hormone releasing factor (GH-RF) activity in the rat stalk-median eminence (SME), and to reveal the relationship between GH-RF activity in SME and plasma GH levels under ether-laparotomy stress in the rat. SME extract was incubated with a total of 8 quartered anterior pituitaries. GH released into the medium was measured by polyacrylamide gel disc electrophoresisdensitometry system, and was used as an index of GH-RF activity. Plasma GH levels were estimated by the Rat GH radioimmunoassay kit (NIAMD).Under manual handling, no significant change occurred in the levels of GH-RF activity in SME and in plasma GH levels. The ether-laparotomy (EL) stress caused a significant rise in GH-RF activity in SME at 15min and reciprocally a significant decrease in plasma GH at 5min and 15min after starting of EL stress. Namely, there was an inverse relationship between the response of GH-RF activity in SME and that of plasma GH under EL stress. These findings may suggest that the EL stress depress the GH secretion via the hypothalamus, and diminition of GH secretion could be attributed to inhibition of GH-RF release or increased secretion of an inhibitory factor.

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Hypothalamic Neurohormones Regulating Anterior Pituitary Function

Cited by 115 publications

References 194 publications

Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

Characterization of the Hormonal Responses to Luteinizing Hormone-Releasing Hormone (LH-RH) in Prepubertal and Adult Subjects

13C-nuclear magnetic resonance study of [85% 13C-enriched proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of the proline residue.

Growth Hormone Releasing Factor Activity in the Stalk-Median Eminence and Plasma Growth Hormone Response to the Ether-Laparotomy Stress in the Rat

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