Hypothalamic monoamines in cold stress on the background of changes in the activity of the nitric oxide system

Gilinskii, M. A.; Petrakova, G. M.; Amstislavskaya, Tamara G.; Maslova, L. N.; Булыгина, В. В.

doi:10.1007/s11055-005-0064-7

Cited by 6 publications

(5 citation statements)

References 11 publications

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“…The acute cold stress applied in our experiments did not reduce the hypothalamic catecholamine stores of either control or long-term isolated rats. This agrees with the results of Gilinskii et al (21) who found that cold stress did not affect hypothalamic DA content. However, cold stress reduces the DA stores in the hippocampus of control and long-term isolated rats.…”

Section: Discussionsupporting

confidence: 93%

Effects of stress on catecholamine stores in central and peripheral tissues of long-term socially isolated rats

Dronjak

Gavrilović

2006

Braz J Med Biol Res

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Both the peripheral sympatho-adrenomedullary and central catecholaminergic systems are activated by various psycho-social and physical stressors. Catecholamine stores in the hypothalamus, hippocampus, adrenal glands, and heart auricles of long-term socially isolated (21 days) and control 3-month-old male Wistar rats, as well as their response to immobilization of all 4 limbs and head fixed for 2 h and cold stress (4ºC, 2 h), were studied. A simultaneous single isotope radioenzymatic assay based on the conversion of catecholamines to the corresponding O-methylated derivatives by catechol-O-methyltransferase in the presence of S-adenosyl-l-( 3 H-methyl)-methionine was used. The O-methylated derivatives were oxidized to 3 H-vanilline and the radioactivity measured. Social isolation produced depletion of hypothalamic norepinephrine (about 18%) and hippocampal dopamine (about 20%) stores and no changes in peripheral tissues. Immobilization decreased catecholamine stores (approximately 39%) in central and peripheral tissues of control animals. However, in socially isolated rats, these reductions were observed only in the hippocampus and peripheral tissues. Cold did not affect hypothalamic catecholamine stores but reduced hippocampal dopamine (about 20%) as well as norepinephrine stores in peripheral tissues both in control and socially isolated rats, while epinephrine levels were unchanged. Thus, immobilization was more efficient in reducing catecholamine stores in control and chronically isolated rats compared to cold stress. The differences in rearing conditions appear to influence the response of adult animals to additional stress. In addition, the influence of previous exposure to a stressor on catecholaminergic activity in the brainstem depends on both the particular catecholaminergic area studied and the properties of additional acute stress. Therefore, the sensitivity of the catecholaminergic system to habituation appears to be tissuespecific.

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Section: Discussionsupporting

confidence: 93%

Effects of stress on catecholamine stores in central and peripheral tissues of long-term socially isolated rats

Dronjak

Gavrilović

2006

Braz J Med Biol Res

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“…The peptides of the Tyr‐MIF‐1 family are termed AOP indicating that the morphine‐induced changes in neuronal responses involve various non‐opioid neurotransmitter networks that participate in a homeostatic system, which acts to dampen the effects of opioids. Some morphological studies provide evidence for the existence of a signalling pathway between an opioidergic and the nitric oxide‐ergic systems in the hypothalamus of the rat brain (Gilinskii et al. , 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of Tyr‐MIF‐1 peptides on blood ACTH and corticosterone concentration induced by three experimental models of stress

Bocheva

Dzambazova

Hadjiolova

et al. 2008

Auton Autocoid Pharmacol

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1. Studies, using a wide variety of stressors, have clearly indicated that the pattern of neuroendocrine response is dependent upon the stress stimulus applied. 2. The Tyr-MIF-1 family of peptides (Tyr-MIF-1s) includes MIF-1, Tyr-MIF-1, Tyr-W-MIF-1 and Tyr-K-MIF-1. These neuropeptides, neuromodulators are able to inhibit the expression of some forms of stress-induced analgesia. 3. The aim of this study was to compare changes in ACTH and corticosterone (CORT) concentration after various stressors (immobilization, cold and heat), as well as after injection of investigated Tyr-MIF-1s peptides. 4. According to our results, hypothalamic-pituitary-adrenal (HPA) system was activated by all the stressors applied. Heat and immobilization are stronger stressors, as the exposure of animals to a high ambient temperature and immobilization resulted in the highest rise of plasma ACTH and CORT concentration when compared with cold stress. Moreover, all the investigated peptides from Tyr-MIF-1 family, administered after application of stressors, inhibited the elevations in adrenocorticotropic hormone (ACTH) and corticosterone (CORT) plasma concentrations significantly. 5. In conclusion, the various stressors applied seem to induce a different response of the HPA system as judged by quantitative changes in ACTH and CORT release. We suggest that Tyr-MIF-1 peptides may possess anti-stressor effects, as they inhibited stress-induced rising in two hormones that were investigated.

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“…According to literature data that NO plays an important role in regulating the response of the HPA axis to various stressors. Some morphological studies have provided evidence for the existence of a signaling pathway between an opioid-and the nitric oxideergic systems in the hypothalamus of rat brain 44,45,46 . On the other hand, KTP is rapidly metabolized to L-Arg, which ia possible substrate for inducible and neuronal nitric oxide synthase NOS 47 .…”

Section: Discussionmentioning

confidence: 99%

Possible Anti-Stressor Effects of Kyotorphin and its Optical Isomer

Dzhambazov¹

2015

Pharmacologia

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Background and Objective: Kyotorphin (KTP), an endogenous analgesic neuropeptide in the central nervous system, is considered to be a neurotransmitter or neuromodulator. D-kyotorphin (D-KTP) is a synthetic analogue of KTP. Both peptides bind to a specific receptor and induced Met-enkephalin release. Thus, the effects of both peptides fall into two clearly identifiable groups: the ones, mediated via opioid peptides and the opioid peptideindependent ones. For a long time we have been interested in the neuromodulating properties of KTP and D-KTP in analgesia due to different types of stress. Our previous data showed that both peptides reduced stress-induced analgesia, which suggest that they may act as an anti-opioid peptides counteracting the effects of stress. During acute stress increased secretion of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) plays a key regulatory role on the basal activity of the hypothalamic-pituitary-adrenal axis and on the termination of the stress response. The aim of this study was to compare changes in ACTH and CORT concentration after various stressors, as well as after injection of KTP or D-KTP. Materials and Methods: The male Wistar rats were injected with KTP or D-KTP immediately after exposure of acute immobilization, cold and heat stresses. After decapitation plasma ACTH and CORT were assayed by a double antibody radioimmunoassay method. Results and Conclusion: The various stressors applied seem to induce a different response of the HPA system as judged by quantitative changes in ACTH and CORT release. In addition, this study points to KTP and its synthesized optical isomer D-KTP as a possible antistressor substances with potential clinical importance in the context of stress-related disorders, since they inhibited stress-induced elevations in two investigated hormones helping the organism to reach homeostatic level. Further studies are needed to understand the exact role of KTP in stress response.

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Hypothalamic monoamines in cold stress on the background of changes in the activity of the nitric oxide system

Cited by 6 publications

References 11 publications

Effects of stress on catecholamine stores in central and peripheral tissues of long-term socially isolated rats

Effects of stress on catecholamine stores in central and peripheral tissues of long-term socially isolated rats

Effect of Tyr‐MIF‐1 peptides on blood ACTH and corticosterone concentration induced by three experimental models of stress

Possible Anti-Stressor Effects of Kyotorphin and its Optical Isomer

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