Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system

Dilman, V.M.; Anisimov, Vladimir N.

doi:10.1016/0531-5565(79)90015-9

Cited by 42 publications

(36 citation statements)

References 30 publications

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“…A number of chemical carcinogens as well as exposure to ionizing radiation also cause decreases and/or disturbances in biogenic amines in the hypothalamus (Anisimov 1987;Arutjunyan et al 2001). The hypothalamic threshold of the sensitivity to feedback inhibition is a key mechanism of agerelated of switching-off of reproductive function in female rodents and women (Dilman and Anisimov 1979a;Dilman 1994). We have found that exposure to various chemical carcinogens leads to a similar phenomena (Anisimov 1987).…”

Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 89%

“…It was shown that centenarians have a preserved glucose tolerance and sensitivity to insulin as well as a lower degree of oxidative stress as compared to other aged persons (Barbieri et al 2003). It is perhaps not unrelated to these findings that hyperinsulinemia is also known to be an important factor in the development of cancer as well (Dilman 1994;Colangelo et al 2002;Gupta et al 2002).…”

Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 90%

“…There is a great deal of evidence that hyperinsulinemia favors accumulation of oxidized proteins by reducing their degradation as well as facilitating protein oxidation by increasing the steady-state level of oxidative stress (Facchini et al 2000). Untreated diabetics with elevated glucose levels suffer many manifestations of accelerated aging, such as impaired wound healing, obesity, cataracts, vascular and microvascular damage (Dilman 1994). It was shown that centenarians have a preserved glucose tolerance and sensitivity to insulin as well as a lower degree of oxidative stress as compared to other aged persons (Barbieri et al 2003).…”

Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 99%

“…In other words, the high prevalence of cancer in older individuals simply reflects a more prolonged exposure to carcinogens (Peto et al 1985). The second hypothesis proposes that age-related progressive changes in the internal milieu of the organism may provide an increasingly favorable environment for the induction of new neoplasia and for the growth of already existent, but latent malignant cells (Anisimov 1983(Anisimov , 2003aMiller 1991;Dilman 1994;Simpson 1993). These mechanisms may also include proliferative senescence, as the senescent cells lose their ability to undergo apoptosis and produce some factors which stimulate epithelial cells with oncogenic mutations (Campisi 2000(Campisi , 2005.…”

Section: Introductionmentioning

confidence: 98%

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Relationships between cancer and aging: a multilevel approach

2009

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The incidence of cancer increases with age in humans and in laboratory animals alike. There are different patterns of age-related distribution of tumors in different organs and tissues. Aging may increase or decrease the susceptibility of various tissues to initiation of carcinogenesis and usually facilitates promotion and progression of carcinogenesis. Aging may predispose to cancer in two ways: tissue accumulation of cells in late stages of carcinogenesis and alterations in internal homeostasis, in particular, alterations in immune and endocrine systems. Increased susceptibility to the effects of tumor promoters is found both in aged animals and aged humans, as predicted by the multistage model of carcinogenesis. Aging is associated with a number of events at the molecular, cellular and physiological levels that influence carcinogenesis and subsequent cancer growth. An improved understanding of age-associated variables impacting on the tumor microenvironment, as well as the cancer cells themselves, will result in improved treatment modalities in geriatric oncology.

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Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 89%

Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 90%

Section: Aging and Carcinogenesesis: Relationship At The Systemic/orgmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Relationships between cancer and aging: a multilevel approach

2009

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“…2 We have found that exposure to the LL regimen leads to increases in the threshold of sensitivity of the hypothalamus to feedback inhibition by estrogens in female rats. 28 This is crucial in the aging of reproductive system in female rats as well as in women. 28 -30 Disturbances in estrous function developed earlier in CBA mice from the LL group.…”

Section: Discussionmentioning

confidence: 99%

Effect of exposure to light‐at‐night on life span and spontaneous carcinogenesis in female CBA mice

Anisimov

Baturin

Popovich

et al. 2004

Intl Journal of Cancer

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The effect of constant illumination on the development of spontaneous tumors in female CBA mice was investigated. Fifty female CBA mice starting from the age of 2 months were kept under standard light/dark regimen (12 hr light: 12hr dark; LD) and 50 CBA mice of similar age were kept under constant illumination (24 hr a day, 2,500 Lux, LL). Exposure to the LL regimen decreased food consumption but did not influence body weight, significantly accelerated age-related disturbances in estrous function, and was followed by a significant increase in spontaneous tumor incidence in female CBA mice. Tumor incidence as well as the number of total or malignant tumors was significantly increased in the LL group compared to the LD group (p < 0.001). The incidence of lung adenocarcinomas, leukemias and hepatocarcinomas was 7/50; 6/50 and 4/50 in the LL group and 1/50; 0/50 and 0/50 in the LD group. Mice from the LL groups had shorter life spans then those from the LD group. The data demonstrate, for the first time, that exposure to constant illumination was followed by increases in the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice. Alternation of the day and night circadian cycle is an important regulator of a wide variety of physiological rhythms in organisms. Light exposure at night has been found to be related to a number of serious behavioral and health problems including cancer. In rodents, light-at-night leads to disruption of the ovulatory cycle followed by hyperplastic processes and tumor development in mammary gland, ovaries and uteri. 1,2 A tumor-promoting effect of exposure to the LL regimen was shown on chemical carcinogenesis in the mammary gland of rats. [3][4][5][6] Prolonged light exposure suppresses the night peak of melatonin, the 'hormone of the night.' 7,8 Melatonin is the principal hormone of the pineal gland, the small neuroendocrine gland connected with the brain that mediates information on light from the retina to the organism. 7,8 A significant increase in the risk of breast and colorectal cancers was shown in women who frequently did not sleep during the period of the night, about 1:30 a.m., when melatonin levels are typically the highest. 9 -12 The 'Melatonin hypothesis' suggests reduced pineal melatonin production might increase human breast cancer risk because lower melatonin output would lead to an increase in female sex hormones and stimulate proliferation of breast tissue. 13 Data on the enhancing effect of constant illuminations on spontaneous endometrial carcinogenesis in BDII/Han rats 14 agree with this suggestion. There are data on the promoting effect of the LL regimen on hepatocarcinogenesis induced by N-nitrosodimethylamine (DENA) in rats 15 and on the development of neurogenic and kidney tumors in progeny of rats exposed to N-nitrosomethylurea in utero. 16 We report, for the first time, that exposure to constant illumination increased the incidence of spontaneous lung carcinoma, leukemias and hepatocarcinoma in female CBA mice. MATERIAL AND ME...

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Biological Interactions of Aging and Carcinogenesis

Anisimov

Cancer Treatment and Research

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Hypothalamic mechanisms of ageing and of specific age pathology—I. Sensitivity threshold of hypothalamo-pituitary complex to homeostatic stimuli in the reproductive system

Cited by 42 publications

References 30 publications

Relationships between cancer and aging: a multilevel approach

Relationships between cancer and aging: a multilevel approach

Effect of exposure to light‐at‐night on life span and spontaneous carcinogenesis in female CBA mice

Biological Interactions of Aging and Carcinogenesis

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