Hypothalamic Ghrelin Suppresses Pulsatile Secretion of Luteinizing Hormone via β-Endorphin in Ovariectomized Rats

Ogata, Rie; Matsuzaki, Takashi; Iwasa, Takeshi; Kiyokawa, Machiko; Tanaka, Naoko; Kuwahara, Akira; Yasui, Toshiyuki; Irahara, Minoru

doi:10.1159/000257421

Cited by 39 publications

(48 citation statements)

References 67 publications

(51 reference statements)

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“…Leptin was largely described to play an essential role in reproduction since db/db mice, which are deleted for leptin gene receptor, and ob/ob mice, which are deleted for leptin gene, are infertile (6,18). Moreover, upregulation of ghrelin induced a decrease in LH surge (26,53), even if the mechanisms involved are yet unknown. Chronic exposition to corticosterone inhibited LH secretion and estrous cycle and ovulation in female rodents (9,10).…”

Section: E252 Chronic Food Restriction and Physical Activitymentioning

confidence: 99%

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?

Méquinion

Caron

Zgheib

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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Section: E252 Chronic Food Restriction and Physical Activitymentioning

confidence: 99%

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?

Méquinion

Caron

Zgheib

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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“…Ghrelin also affects the reproductive system. For example, central ghrelin injection to OVX rats, or OVX rats treated with E 2 , suppressed LH concentration and pulse frequency (Furuta et al 2001, Ogata et al 2009). Similar inhibitory effects on LH secretion were observed throughout the estrus cycle (Fernandez-Fernandez et al 2005).…”

Section: Ghrelinmentioning

confidence: 99%

Kisspeptin and energy balance in reproduction

Bond¹,

Smith²

2014

Reproduction

104

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Kisspeptin is vital for the neuroendocrine regulation of GNRH secretion. Kisspeptin neurons are now recognized as a central pathway responsible for conveying key homeostatic information to GNRH neurons. This pathway is likely to mediate the well-established link between energy balance and reproductive function. Thus, in states of severely altered energy balance (either negative or positive), fertility is compromised, as is Kiss1 expression in the arcuate nucleus. A number of metabolic modulators have been proposed as regulators of kisspeptin neurons including leptin, ghrelin, pro-opiomelanocortin (POMC), and neuropeptide Y (NPY). Whether these regulate kisspeptin neurons directly or indirectly will be discussed. Moreover, whether the stimulatory role of leptin on reproduction is mediated by kisspeptin directly will be questioned. Furthermore, in addition to being expressed in GNRH neurons, the kisspeptin receptor (Kiss1r) is also expressed in other areas of the brain, as well as in the periphery, suggesting alternative roles for kisspeptin signaling outside of reproduction. Interestingly, kisspeptin neurons are anatomically linked to, and can directly excite, anorexigenic POMC neurons and indirectly inhibit orexigenic NPY neurons. Thus, kisspeptin may have a direct role in regulating energy balance. Although data from Kiss1r knockout and WT mice found no differences in body weight, recent data indicate that kisspeptin may still play a role in food intake and glucose homeostasis. Thus, in addition to regulating reproduction, and mediating the effect of energy balance on reproductive function, kisspeptin signaling may also be a direct regulator of metabolism.

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“…For instance, the general opioid antagonist, naltrexone, injected into the nucleus accumbens (NAc) did not affect feeding elicited by ghrelin injection into the VTA, and naltrexone in the VTA did not affect feeding elicited by ghrelin injected into the NAc (Naleid et al, 2005). Additionally, there are indication that some of the central pharmacological actions of ghrelin are opioid mediated such as pain (Sibilia et al, 2006) and pulsatile luteinizing hormone secretion (Ogata et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

Romero‐Picó

Vázquez

González-Touceda

et al. 2013

Neuropsychopharmacol

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The opioid system is well recognized as an important regulator of appetite and energy balance. We now hypothesized that the hypothalamic opioid system might modulate the orexigenic effect of ghrelin. Using pharmacological and gene silencing approaches, we demonstrate that ghrelin utilizes a hypothalamic k-opioid receptor (KOR) pathway to increase food intake in rats. Pharmacological blockade of KOR decreases the acute orexigenic effect of ghrelin. Inhibition of KOR expression in the hypothalamic arcuate nucleus is sufficient to blunt ghrelin-induced food intake. By contrast, the specific inhibition of KOR expression in the ventral tegmental area does not affect central ghrelin-induced feeding. This new pathway is independent of ghrelin-induced AMP-activated protein kinase activation, but modulates the levels of the transcription factors and orexigenic neuropeptides triggered by ghrelin to finally stimulate feeding. Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin.

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Hypothalamic Ghrelin Suppresses Pulsatile Secretion of Luteinizing Hormone via β-Endorphin in Ovariectomized Rats

Cited by 39 publications

References 67 publications

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?

Physical activity: benefit or weakness in metabolic adaptations in a mouse model of chronic food restriction?

Kisspeptin and energy balance in reproduction

Hypothalamic κ-Opioid Receptor Modulates the Orexigenic Effect of Ghrelin

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