Hypothalamic dysfunction in a child: A distinct syndrome?

Proulx, François; Weber, M; Collu, R.; LeLievre, Matthew; Larbrisseau, Albert; Delisle, Marie-Soleil

doi:10.1007/bf01955066

Cited by 28 publications

(19 citation statements)

References 2 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] This paper provides a comprehensive review of the literature to date. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] This paper provides a comprehensive review of the literature to date.…”

Section: Idiopathic Hypothalamic Dysfunction: a Paraneoplastic Syndrome?mentioning

confidence: 99%

Idiopathic Hypothalamic Dysfunction: A Paraneoplastic Syndrome?

Nunn¹,

Ouvrier²,

Sprague³

et al. 1997

J Child Neurol

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Section: Idiopathic Hypothalamic Dysfunction: a Paraneoplastic Syndrome?mentioning

confidence: 99%

Idiopathic Hypothalamic Dysfunction: A Paraneoplastic Syndrome?

Nunn¹,

Ouvrier²,

Sprague³

et al. 1997

J Child Neurol

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“…Appetite and weight control is likely to be influenced by complex anatomical, biochemical and endocrinological pathways in the central nervous system which may be disrupted following ABI. Hypothalamic and pituitary tumours, for example, are associated with obesity [3,4]. Additional factors may include impaired mobility, reduced level of activity, lack of motivation, disinhibition and impulsive behaviour.…”

Section: Introductionmentioning

confidence: 97%

Obesity in children and adolescents with acquired brain injury

Patradoon-Ho¹,

Scheinberg²,

Baur

2005

Pediatric Rehabilitation

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Objectives: To measure the prevalence of obesity and to assess associated clinical factors in children and adolescents with acquired brain injury (ABI). Study design: This cross-sectional study included 88 subjects aged between 2.4-17.7 years attending the Brain Injury Clinic at a tertiary paediatric hospital. Body mass index (BMI) and BMI z-scores were calculated. Obesity and overweight were defined using the International Obesity Taskforce cut-points. Associations were examined between BMI z-scores and the following: ABI severity, mobility level, duration from injury and presence of radiological injury. Results: The prevalence of obesity in this population (obese =15%) was higher than those in Australian children and adolescents (1995 National Nutrition Survey) while the prevalence of overweight (19.3%) was comparable. There was a linear trend for the participants to have a higher BMI z-score with increasing level of mobility (F=6.91, df 1.70, p = 0.011). Conclusion: There is no data about obesity in children and adolescents with ABI. The study with limited statistical power suggests that obesity is prevalent in this population and increases with increasing level of mobility. Further studies are required to address the issue of obesity and related complications in this population. Keywords: Traumatic brain injury, overweight, body mass indexObjetivos: Medir la prevalencia de la obesidad y evaluar los factores clinicos asociados en ninos y adolescentes con lesion cerebral adquirida (ABI). Diseno del estudio: Este estudio transversal incluyo a 88 sujetos con edades entres los 2.4 y los 17.7 anos, que asisdan a la Clinica de Trauma Cerebral en un hospital pediatrico de tercer nivel. Se calcularon el indice de masa corporal (BMI) y las calificaciones-z del BMI. La obesidad y el sobrepeso se definieron usando los puntos de corte de la Fuerza de Tarea de Obesidad Intemacional. Se examinaron las asociaciones entre las calificaciones-z del BMI y los siguientes puntos: la severidad de la ABI, el nivel de movilidad, la duracion de la lesion y la presencia de la lesion radiologica. Resultados: La prevalencia de la obesidad en esta poblacion (Obeso =15%) fue mas alta que aquella encontrada en los nifios y adolescentes australianos (Encuesta de Nutricion Nacional 1995), mientras que la prevalencia del sobrepeso (19.3%) fue comparable. Hubo una tendencia lineal para los participantes en tener calificaciones-z del BMI mas altas conforme al aumento en el nivel de la movilidad (F=6.9l, DF 1,70, p = 0.01l). Conclusion: No hay datos acerca de la obesidad en ninos y adolescentes con ABI. Nuestro estudio con un poder estadistico limitado, sugiere que la obesidad prevalece en esta poblacion y que aumenta con el aumento en el nivel de la movilidad. Se requieren mas estudios que se dediquen al tema de la obesidad y a las complicaciones relacionadas en esta poblacion.

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“…Hypertriglyceredemia in association with hypernatremia was reported in few children. (8,12,14,(18)(19)(20)25) Interestingly, a similar association was reported in a dog. (28) In some of these reports the association was discovered when the plasma was observed to be lipemic.…”

Section: Introductionmentioning

confidence: 58%

“…(5, 6) Essential hypernatremia was reported in a number of Pediatric patients as idiopathic (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) or secondary to hypothalamic inflammation, tumors and cerebral malformations. (18)(19)(20)(21)(22)(23)(24)(25)(26)(27) Serum lipids are rarely measured in patients with hypernatremia.…”

Section: Introductionmentioning

confidence: 99%