Abstract:Objectives: Hypothalamic digoxin, an isoprenoidal metabolite, is an endogenous regulator of membrane Na+-K+ ATPase activity, immune activation and synaptic neurotransmission. The objective of this study was to assess the role of hypothalamic digoxin and hemispheric dominance in the pathogenesis of the acquired immunodeficiency syndrome (AIDS) and in the genesis of sexual orientation. Methods: The isoprenoid-pathway-related cascade – (i) isoprenoidal metabolites – digoxin, dolichol and ubi… Show more
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