“…In a previous study, Höcht, Opezzo, and Taira (2005a) evaluated the possible hypothalamic antihypertensive effect of metoprolol and its action on aminergic neurotransmission in sham operated and aortic coarctated hypertensive rats using the reverse microdialysis technique. Intrahypothalamic perfusion with metoprolol induced a significative decrease of blood pressure in coarctated hypertensive animals but not in normotensive rats.…”