Hypotensive Alkaloids of Veratrum Eschscholtzii

Review: Veratrum californicum Alkaloids

“…Isolation of 3 from V. eschscholtzii Gray was achieved by crude chloroform extraction. A Craig countercurrent distribution was performed on this extract to separate the alkaloids and identify 3 [ 71 ]. In a separate study, the roots and rhizomes of V. taliense were dried and ground before being extracted with methanol.…”

Studies on Veratrum. II. Veratrum Eschscholtzii A. Gray; Observations on Seed Germination and Early Growth of Seedlings of Veratrum Species

“…The dried rhizomes and roots of Vereratrzim Eschscholtzii are now being investigated chemically and have blready been reported to contain a number df the same alkaloids found in Veratrum viride, namely, jenrine, rubijervine, pseudojervine, and veratramine (2). album.…”

The Isolation of Crystalline Hypotensive Veratrum Ester Alkaloids by Chromatography1

“…3 This development has, in turn, stimulated much active research on the isolation and characterization of the hypotensive tertiary alkamine ester alkaloids which occur in Veratrum and related plants, and nearly a dozen new members of the series have been reported during the past few years. [4][5][6][7][8] Widespread clinical use and chemical study of the individual ester alkaloids have been retarded by the difficulties encountered in isolation of pure, crystalline compounds. The isolation of individual alkaloids has been accomplished only by methods involving use of excessively time-consuming countercurrent distribution procedures unsuitable for large-scale purification.4-8…”