Hyposensitization with a Tyrosine Adsorbed Extract of Dermatophagoides pteronyssinus in Adults with Perennial Rhinitis

Abstract

Hyposensitization with a tyrosine adsorbed extract of Dermatophagoides pteronyssinus was effective in relieving symptoms in selected patients with perennial rhinitis due to this allergen who had responded poorly to topical application of steroids. There was a significant reduction in the nasal response to allergen after six weekly injections only in the actively treated group, but symptomatic improvement greater than that produced by placebo therapy was only evident after a further 10 months of monthly injections. Significantly more placebo-treated patients considered that therapy was ineffective and withdrew from the study. Only one patient developed significant unwanted effects from the injection therapy and had to be withdrawn from the study. We conclude that hyposensitization with a tyrosine adsorbed extract of Dermatophagoides pteronyssinus can be a safe and effective treatment for adults with perennial rhinitis due to this allergen who have responded poorly to nasal corticosteroids, and that those patients who eventually respond clinically are likely to have a diminished nasal response to allergen after the first 6 weeks of therapy.

The control of allergens of dust mites and domestic pets: a position paper

“…By way of contrast, prevalence of skin test positivity is < 10% in asymptomatic populations [34,35]. Nasal insuffiation with house-dust mite extract reproduces the symptoms of rhinitis in sensitized people, and there are several trials that have indicated benefit of immunotherapy with mite extracts in the treatment of this condition [36][37][38][39]. Thus, there is substantial evidence to link house-dust mite hypersensitivity with the expression of rhinitis.…”

Immunotherapy as an effective tool in allergy treatment

“…Nine studies investigated other pollen allergens: mountain cedar (10,27,29), Parietaria (42,43,46), Cupressus (45), Cocos (41), and mixtures (6); efficacy was demonstrated in six. The efficacy of house-dust-mite immunotherapy (14,24,26,28,33) was based on five studies (three showing efficacy). In mold allergies, efficacy was documented in one study investigating Alternaria (31).…”

Treatment of patients allergic to house dust mites

“…Two recent papers have reported a positive effect on nasal symptoms (9,14), whereas in two L. HAUGAARD ET AL. other studies a positive effect has been shown, but only in some of the parameters examined (4,15).…”