Hypopyon after repeated transplantation of human amniotic membrane onto the corneal surface

Gabler, Bernhard

doi:10.1016/s0161-6420(00)00167-6

Cited by 48 publications

(24 citation statements)

References 18 publications

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“…Although cases of presensitization do not occur in clinical scenarios, many cases need repeated transplantation and rejection after repeated transplantation has been reported. 17 These data clearly show that rejection arises after repeated AE allo-grafting.…”

Section: Discussionmentioning

confidence: 67%

Immunological Characteristics of Amniotic Epithelium

Hori

Wang²,

Kamiya³

et al. 2006

Cornea

128

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We review recent experimental evidence of the immunosuppressive and immunogenic potential of amniotic epithelial cells. Since cryopreserved amniotic membrane (AM) has been used in clinical applications, much research has focused on the beneficial effects of amniotic stromal matrix rather than on the function of viable amniotic cells. However, viable human amniotic epithelial cells (HAECs) have been shown to elicit beneficial effects on secretion of anti-inflammatory factors. Topical application of culture supernatant from HAECs leads to profound suppression of suture-induced neovascularization in cornea and fewer major histocompatibility complex (MHC) class II antigen-presenting cells (APCs) in inflamed cornea after thermal cautery. Furthermore, expression of interleukin (IL)-1beta mRNA was suppressed in cauterized cornea. These results suggest that HAECs are a source of soluble anti-inflammatory factors that suppress corneal inflammation. However, viable amniotic epithelial cells display antigenicity and immunogenicity as allografts. Fresh allogeneic amniotic epithelium (AE) expresses MHC class I antigens and sensitizes recipients when placed in the eye, although long-term memory of allo-specific delayed hypersensitivity (DH) was not acquired. Allogeneic AE was clearly vulnerable to acute immune rejection in specifically sensitized recipients and recipients of repeated AE transplantation. We therefore suggest that immunogenicity of AE should not be ignored, and use of AM from different donor placentas should be emphasized when repeated AM transplantation is required in patients clinically.

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Section: Discussionmentioning

confidence: 67%

Immunological Characteristics of Amniotic Epithelium

Hori

Wang²,

Kamiya³

et al. 2006

Cornea

128

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“…Postoperative IOP was controlled between 9 mmHg and 15 mmHg in all patients, with a maximum of three glaucoma medications (one medication in four patients, two in one, and three in one). No patients underwent a recurrence of bleb leak or AMT-related complications such as bleb infection and noninfectious, immune-mediated hypopyon [19] during the entire follow-up. All patients showed diffuse blebs, which extended posteriorly beyond the conjunctival incision, at final visit (Fig.…”

Section: Resultsmentioning

confidence: 98%

Long-term results of amniotic membrane transplantation-assisted bleb revision for leaking blebs

Nagai-Kusuhara

Nakamura

Fujioka

et al. 2007

Graefes Arch Clin Exp Ophthalmol

106

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“…3 We report a well-epithelialized corneal graft melting at the graft-host interface 2 weeks after overlying amniotic membrane transplantation. A systemic immune reaction is unlikely given the negative workup, nor could localized infection be implicated.…”

Section: Discussionmentioning

confidence: 94%